Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073417552> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2073417552 endingPage "126" @default.
- W2073417552 startingPage "121" @default.
- W2073417552 abstract "Opsoclonus-myoclonus syndrome is one of a few corticotropin (ACTH)-responsive central nervous system disorders of childhood. We measured cerebrospinal fluid ACTH and cortisol in 69 children with opsoclonus-myoclonus and 25 age- and sex-matched control subjects to determine endogenous levels and look for hypothesized differential hormonal effects of ACTH and corticosteroid treatment. Cerebrospinal fluid cortisol was 10-fold higher with ACTH treatment (n = 26), but was unchanged with oral steroid treatment (n = 18) or no treatment (n = 25). It was significantly higher in children receiving daily high-dose ACTH than alternate day ACTH. In ACTH-treated children, cerebrospinal fluid and serum cortisol were highly correlated (<i>r</i> = 0.96, <i>P</i> = 0.0001), with a mean ratio of cerebrospinal fluid to serum cortisol of approximately 1:10. Cerebrospinal fluid ACTH concentration did not differ significantly between untreated opsoclonus-myoclonus and control subjects but was lower with ACTH (−29%) or steroid treatment (−36%), suggesting feedback inhibition of ACTH release. These data delineate differences in the central effects of ACTH and corticosteroid therapy, as well as between high and low ACTH doses, and support the integrity of the brain-adrenal axis in pediatric opsoclonus-myoclonus." @default.
- W2073417552 created "2016-06-24" @default.
- W2073417552 creator A5004880003 @default.
- W2073417552 creator A5009223634 @default.
- W2073417552 creator A5073168915 @default.
- W2073417552 creator A5073621105 @default.
- W2073417552 creator A5088684470 @default.
- W2073417552 date "2005-08-01" @default.
- W2073417552 modified "2023-09-24" @default.
- W2073417552 title "Cerebrospinal Fluid ACTH and Cortisol in Opsoclonus-Myoclonus: Effect of Therapy" @default.
- W2073417552 cites W1526872663 @default.
- W2073417552 cites W1590647515 @default.
- W2073417552 cites W1967774243 @default.
- W2073417552 cites W1981070612 @default.
- W2073417552 cites W2000056249 @default.
- W2073417552 cites W2005344985 @default.
- W2073417552 cites W2007472281 @default.
- W2073417552 cites W2013233268 @default.
- W2073417552 cites W2027566786 @default.
- W2073417552 cites W2029146004 @default.
- W2073417552 cites W2043132687 @default.
- W2073417552 cites W2044991304 @default.
- W2073417552 cites W2049962352 @default.
- W2073417552 cites W2055519944 @default.
- W2073417552 cites W2055833317 @default.
- W2073417552 cites W2071895432 @default.
- W2073417552 cites W2081525535 @default.
- W2073417552 cites W2089178545 @default.
- W2073417552 cites W2093164343 @default.
- W2073417552 cites W2114420323 @default.
- W2073417552 cites W2124590494 @default.
- W2073417552 cites W2136898065 @default.
- W2073417552 cites W2138601341 @default.
- W2073417552 cites W2168457697 @default.
- W2073417552 cites W2216655508 @default.
- W2073417552 cites W4242695830 @default.
- W2073417552 cites W4245736815 @default.
- W2073417552 doi "https://doi.org/10.1016/j.pediatrneurol.2005.03.004" @default.
- W2073417552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16087057" @default.
- W2073417552 hasPublicationYear "2005" @default.
- W2073417552 type Work @default.
- W2073417552 sameAs 2073417552 @default.
- W2073417552 citedByCount "15" @default.
- W2073417552 countsByYear W20734175522012 @default.
- W2073417552 countsByYear W20734175522014 @default.
- W2073417552 countsByYear W20734175522016 @default.
- W2073417552 countsByYear W20734175522017 @default.
- W2073417552 countsByYear W20734175522020 @default.
- W2073417552 crossrefType "journal-article" @default.
- W2073417552 hasAuthorship W2073417552A5004880003 @default.
- W2073417552 hasAuthorship W2073417552A5009223634 @default.
- W2073417552 hasAuthorship W2073417552A5073168915 @default.
- W2073417552 hasAuthorship W2073417552A5073621105 @default.
- W2073417552 hasAuthorship W2073417552A5088684470 @default.
- W2073417552 hasConcept C126322002 @default.
- W2073417552 hasConcept C134018914 @default.
- W2073417552 hasConcept C2776538686 @default.
- W2073417552 hasConcept C2776804153 @default.
- W2073417552 hasConcept C2778709874 @default.
- W2073417552 hasConcept C2779651940 @default.
- W2073417552 hasConcept C2780546910 @default.
- W2073417552 hasConcept C42219234 @default.
- W2073417552 hasConcept C71315377 @default.
- W2073417552 hasConcept C71924100 @default.
- W2073417552 hasConceptScore W2073417552C126322002 @default.
- W2073417552 hasConceptScore W2073417552C134018914 @default.
- W2073417552 hasConceptScore W2073417552C2776538686 @default.
- W2073417552 hasConceptScore W2073417552C2776804153 @default.
- W2073417552 hasConceptScore W2073417552C2778709874 @default.
- W2073417552 hasConceptScore W2073417552C2779651940 @default.
- W2073417552 hasConceptScore W2073417552C2780546910 @default.
- W2073417552 hasConceptScore W2073417552C42219234 @default.
- W2073417552 hasConceptScore W2073417552C71315377 @default.
- W2073417552 hasConceptScore W2073417552C71924100 @default.
- W2073417552 hasIssue "2" @default.
- W2073417552 hasLocation W20734175521 @default.
- W2073417552 hasLocation W20734175522 @default.
- W2073417552 hasOpenAccess W2073417552 @default.
- W2073417552 hasPrimaryLocation W20734175521 @default.
- W2073417552 hasRelatedWork W1963881727 @default.
- W2073417552 hasRelatedWork W1986710366 @default.
- W2073417552 hasRelatedWork W2020423578 @default.
- W2073417552 hasRelatedWork W2040148658 @default.
- W2073417552 hasRelatedWork W2067783814 @default.
- W2073417552 hasRelatedWork W2073417552 @default.
- W2073417552 hasRelatedWork W2078224059 @default.
- W2073417552 hasRelatedWork W2082671782 @default.
- W2073417552 hasRelatedWork W2413517451 @default.
- W2073417552 hasRelatedWork W2415092010 @default.
- W2073417552 hasVolume "33" @default.
- W2073417552 isParatext "false" @default.
- W2073417552 isRetracted "false" @default.
- W2073417552 magId "2073417552" @default.
- W2073417552 workType "article" @default.