FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073417900> ?p ?o ?g. }

• W2073417900 endingPage "949" @default.
• W2073417900 startingPage "934" @default.
• W2073417900 abstract "Networks of cortical neurons in vitro spontaneously develop synchronous oscillatory electrical activity at around the second week in culture. However, the underlying mechanisms and in particular the role of GABAergic interneurons in initiation and synchronization of oscillatory activity in developing cortical networks remain elusive. Here, we examined the intrinsic properties and the development of GABAergic and glutamatergic input onto presumed projection neurons (PNs) and large interneurons (L-INs) in cortical cultures of GAD67-GFP mice. Cultures developed spontaneous synchronous activity already at 5-7 days in vitro (DIV), as revealed by imaging transient changes in Fluo-3 fluorescence. Concurrently, spontaneous glutamate-mediated and GABA(A)-mediated postsynaptic currents (sPSCs) occured at 5 DIV. For both types of neurons the frequency of glutamatergic and GABAergic sPSCs increased with DIV, whereas the charge transfer of glutamatergic sPSCs increased and the charge transfer of GABAergic sPSCs decreased with cultivation time. The ratio between GABAergic and the overall charge transfer was significantly reduced with DIV for L-INs and PNs, indicating an overall reduction in GABAergic synaptic drive with maturation of the network. In contrast, analysis of miniature PSCs (mPSCs) revealed no significant changes of charge transfer with DIV for both types of neurons, indicating that the reduction in GABAergic drive was not due to a decreased number of functional synapses. Our data suggest that the global reduction in GABAergic synaptic drive together with more synaptic input to PNs and L-INs during maturation may enhance rhythmogenesis of the network and increase the synchronization at the level of population bursts." @default.
• W2073417900 created "2016-06-24" @default.
• W2073417900 creator A5014431186 @default.
• W2073417900 creator A5019624154 @default.
• W2073417900 creator A5072010861 @default.
• W2073417900 creator A5075647339 @default.
• W2073417900 creator A5091672670 @default.
• W2073417900 date "2008-01-01" @default.
• W2073417900 modified "2023-10-13" @default.
• W2073417900 title "Developmental downregulation of GABAergic drive parallels formation of functional synapses in cultured mouse neocortical networks" @default.
• W2073417900 cites W1482053593 @default.
• W2073417900 cites W1489033370 @default.
• W2073417900 cites W1513345777 @default.
• W2073417900 cites W1518098954 @default.
• W2073417900 cites W1531436913 @default.
• W2073417900 cites W1574509557 @default.
• W2073417900 cites W1611404903 @default.
• W2073417900 cites W1955943544 @default.
• W2073417900 cites W1963482431 @default.
• W2073417900 cites W1963788090 @default.
• W2073417900 cites W1974861764 @default.
• W2073417900 cites W1975486281 @default.
• W2073417900 cites W1976887222 @default.
• W2073417900 cites W1992182809 @default.
• W2073417900 cites W1994480094 @default.
• W2073417900 cites W1996603253 @default.
• W2073417900 cites W2013196233 @default.
• W2073417900 cites W2015441228 @default.
• W2073417900 cites W2022950883 @default.
• W2073417900 cites W2024009242 @default.
• W2073417900 cites W2025603247 @default.
• W2073417900 cites W2026894898 @default.
• W2073417900 cites W2028819787 @default.
• W2073417900 cites W2033191423 @default.
• W2073417900 cites W2036512556 @default.
• W2073417900 cites W2041848975 @default.
• W2073417900 cites W2045095925 @default.
• W2073417900 cites W2053724708 @default.
• W2073417900 cites W2064363302 @default.
• W2073417900 cites W2064509844 @default.
• W2073417900 cites W2066791849 @default.
• W2073417900 cites W2081669905 @default.
• W2073417900 cites W2084146203 @default.
• W2073417900 cites W2094929607 @default.
• W2073417900 cites W2096931059 @default.
• W2073417900 cites W2099314926 @default.
• W2073417900 cites W2102297429 @default.
• W2073417900 cites W2105665255 @default.
• W2073417900 cites W2109749506 @default.
• W2073417900 cites W2119109172 @default.
• W2073417900 cites W2126578880 @default.
• W2073417900 cites W2126862786 @default.
• W2073417900 cites W2139330109 @default.
• W2073417900 cites W2150392035 @default.
• W2073417900 cites W2156780983 @default.
• W2073417900 cites W2158299803 @default.
• W2073417900 cites W2159117162 @default.
• W2073417900 cites W2159806203 @default.
• W2073417900 cites W2167258398 @default.
• W2073417900 cites W2167375169 @default.
• W2073417900 cites W2247356410 @default.
• W2073417900 cites W27230042 @default.
• W2073417900 doi "https://doi.org/10.1002/dneu.20632" @default.
• W2073417900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18361402" @default.
• W2073417900 hasPublicationYear "2008" @default.
• W2073417900 type Work @default.
• W2073417900 sameAs 2073417900 @default.
• W2073417900 citedByCount "20" @default.
• W2073417900 countsByYear W20734179002012 @default.
• W2073417900 countsByYear W20734179002013 @default.
• W2073417900 countsByYear W20734179002014 @default.
• W2073417900 countsByYear W20734179002015 @default.
• W2073417900 countsByYear W20734179002016 @default.
• W2073417900 countsByYear W20734179002018 @default.
• W2073417900 countsByYear W20734179002021 @default.
• W2073417900 countsByYear W20734179002023 @default.
• W2073417900 crossrefType "journal-article" @default.
• W2073417900 hasAuthorship W2073417900A5014431186 @default.
• W2073417900 hasAuthorship W2073417900A5019624154 @default.
• W2073417900 hasAuthorship W2073417900A5072010861 @default.
• W2073417900 hasAuthorship W2073417900A5075647339 @default.
• W2073417900 hasAuthorship W2073417900A5091672670 @default.
• W2073417900 hasConcept C144024400 @default.
• W2073417900 hasConcept C149923435 @default.
• W2073417900 hasConcept C169760540 @default.
• W2073417900 hasConcept C170493617 @default.
• W2073417900 hasConcept C17077164 @default.
• W2073417900 hasConcept C197341189 @default.
• W2073417900 hasConcept C200170125 @default.
• W2073417900 hasConcept C2777771985 @default.
• W2073417900 hasConcept C2779177108 @default.
• W2073417900 hasConcept C2780648746 @default.
• W2073417900 hasConcept C2908647359 @default.
• W2073417900 hasConcept C55493867 @default.
• W2073417900 hasConcept C61174792 @default.
• W2073417900 hasConcept C86803240 @default.
• W2073417900 hasConceptScore W2073417900C144024400 @default.
• W2073417900 hasConceptScore W2073417900C149923435 @default.

• next