FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073419937> ?p ?o ?g. }

• W2073419937 endingPage "298" @default.
• W2073419937 startingPage "293" @default.
• W2073419937 abstract "Alstonia scholaris (Apocynaceae) was documented as an effective herb for the treatment of chronic respiratory diseases in “dai” ethnopharmacy historically, and its leaf crude extract, used for releasing tracheitis and cold symptom, was approved to be a commercial formulation by State Food and Drugs Administration of China (SFDA). The investigation evaluates the anti-tussive and anti-asthmatic activities of the ethanolic extract, fractions and main alkaloids of Alstonia scholaris leaf to provide experimental evidence for its traditional and modern clinical use. For our most interesting, is to reveal the active components for further new drug development. The leaf of Alstonia scholaris was extracted with ethanol and then separated into different fractions. Furthermore, alkaloids were isolated by phytochemical method. The anti-tussive activity was evaluated using three different models including ammonia or sulfur dioxide induced mice coughing, and citric acid induced guinea pigs coughing. The anti-asthmatic activity was investigated on guinea pigs bronchoconstraction induced by histamine. The expectorant activity was evaluated by volume of phenol red in mice's tracheas. The alkaloids fraction significantly inhibited mice's frequency of cough induced by ammonia, increased mice's latent period of cough induced by sulfur dioxide, and increased guinea pigs’ latent period of cough and inhibited frequency of cough. Besides, the alkaloids fraction increased delitescence of convulsion, and tumble of guinea pigs in anti-asthmatic test, and enhanced tracheal phenol red output in expectorant evaluation. Moreover, the main alkaloid, picrinine exhibited anti-tussive and anti-asthmatic activities in vivo. The alkaloids fraction was anti-tussive, anti-asthmatic and expectorant activities component of Alstonia scholaris leaf, and it may also be a valuable lead material for respiratory diseases drug development. Picrinine, the main anti-tussive and anti-asthmatic compound, could be applied in quality control of products from Alstonia scholaris leaf." @default.
• W2073419937 created "2016-06-24" @default.
• W2073419937 creator A5012188875 @default.
• W2073419937 creator A5016239227 @default.
• W2073419937 creator A5046133135 @default.
• W2073419937 creator A5061280924 @default.
• W2073419937 creator A5081917351 @default.
• W2073419937 date "2010-06-01" @default.
• W2073419937 modified "2023-10-16" @default.
• W2073419937 title "Pharmacological evaluation of Alstonia scholaris: Anti-tussive, anti-asthmatic and expectorant activities" @default.
• W2073419937 cites W1522671914 @default.
• W2073419937 cites W1541207577 @default.
• W2073419937 cites W1963530129 @default.
• W2073419937 cites W1985385103 @default.
• W2073419937 cites W1985590917 @default.
• W2073419937 cites W2002092334 @default.
• W2073419937 cites W2012931804 @default.
• W2073419937 cites W2027145701 @default.
• W2073419937 cites W2027624792 @default.
• W2073419937 cites W2040313509 @default.
• W2073419937 cites W2041950913 @default.
• W2073419937 cites W2047180184 @default.
• W2073419937 cites W2058757883 @default.
• W2073419937 cites W2071578789 @default.
• W2073419937 cites W2074462718 @default.
• W2073419937 cites W2076513775 @default.
• W2073419937 cites W2088717850 @default.
• W2073419937 cites W2141474275 @default.
• W2073419937 cites W2333826431 @default.
• W2073419937 cites W2393754013 @default.
• W2073419937 doi "https://doi.org/10.1016/j.jep.2010.03.029" @default.
• W2073419937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20381600" @default.
• W2073419937 hasPublicationYear "2010" @default.
• W2073419937 type Work @default.
• W2073419937 sameAs 2073419937 @default.
• W2073419937 citedByCount "88" @default.
• W2073419937 countsByYear W20734199372012 @default.
• W2073419937 countsByYear W20734199372013 @default.
• W2073419937 countsByYear W20734199372014 @default.
• W2073419937 countsByYear W20734199372015 @default.
• W2073419937 countsByYear W20734199372016 @default.
• W2073419937 countsByYear W20734199372017 @default.
• W2073419937 countsByYear W20734199372018 @default.
• W2073419937 countsByYear W20734199372019 @default.
• W2073419937 countsByYear W20734199372020 @default.
• W2073419937 countsByYear W20734199372021 @default.
• W2073419937 countsByYear W20734199372022 @default.
• W2073419937 countsByYear W20734199372023 @default.
• W2073419937 crossrefType "journal-article" @default.
• W2073419937 hasAuthorship W2073419937A5012188875 @default.
• W2073419937 hasAuthorship W2073419937A5016239227 @default.
• W2073419937 hasAuthorship W2073419937A5046133135 @default.
• W2073419937 hasAuthorship W2073419937A5061280924 @default.
• W2073419937 hasAuthorship W2073419937A5081917351 @default.
• W2073419937 hasConcept C134018914 @default.
• W2073419937 hasConcept C185592680 @default.
• W2073419937 hasConcept C195475562 @default.
• W2073419937 hasConcept C2777667214 @default.
• W2073419937 hasConcept C2778450494 @default.
• W2073419937 hasConcept C2778815084 @default.
• W2073419937 hasConcept C2779824472 @default.
• W2073419937 hasConcept C2909092086 @default.
• W2073419937 hasConcept C2991655182 @default.
• W2073419937 hasConcept C43617362 @default.
• W2073419937 hasConcept C556039675 @default.
• W2073419937 hasConcept C71240020 @default.
• W2073419937 hasConcept C71924100 @default.
• W2073419937 hasConcept C98274493 @default.
• W2073419937 hasConceptScore W2073419937C134018914 @default.
• W2073419937 hasConceptScore W2073419937C185592680 @default.
• W2073419937 hasConceptScore W2073419937C195475562 @default.
• W2073419937 hasConceptScore W2073419937C2777667214 @default.
• W2073419937 hasConceptScore W2073419937C2778450494 @default.
• W2073419937 hasConceptScore W2073419937C2778815084 @default.
• W2073419937 hasConceptScore W2073419937C2779824472 @default.
• W2073419937 hasConceptScore W2073419937C2909092086 @default.
• W2073419937 hasConceptScore W2073419937C2991655182 @default.
• W2073419937 hasConceptScore W2073419937C43617362 @default.
• W2073419937 hasConceptScore W2073419937C556039675 @default.
• W2073419937 hasConceptScore W2073419937C71240020 @default.
• W2073419937 hasConceptScore W2073419937C71924100 @default.
• W2073419937 hasConceptScore W2073419937C98274493 @default.
• W2073419937 hasIssue "3" @default.
• W2073419937 hasLocation W20734199371 @default.
• W2073419937 hasLocation W20734199372 @default.
• W2073419937 hasOpenAccess W2073419937 @default.
• W2073419937 hasPrimaryLocation W20734199371 @default.
• W2073419937 hasRelatedWork W138401483 @default.
• W2073419937 hasRelatedWork W1965609450 @default.
• W2073419937 hasRelatedWork W2090835302 @default.
• W2073419937 hasRelatedWork W2358531527 @default.
• W2073419937 hasRelatedWork W2549128777 @default.
• W2073419937 hasRelatedWork W2581232365 @default.
• W2073419937 hasRelatedWork W3158648783 @default.
• W2073419937 hasRelatedWork W4240009323 @default.
• W2073419937 hasRelatedWork W4315490941 @default.
• W2073419937 hasRelatedWork W2183048828 @default.
• W2073419937 hasVolume "129" @default.

• next