FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073420242> ?p ?o ?g. }

• W2073420242 endingPage "789" @default.
• W2073420242 startingPage "789" @default.
• W2073420242 abstract "Many women using hormone replacement therapy (HRT) will discontinue HRT and lose its bone-protective effect. Methods to preserve bone density in these women need to be explored. This multicenter, international, randomized, blinded, 12-month study was conducted to assess the effect of alendronate sodium on bone density in women who had recently discontinued HRT.The 144 postmenopausal women included in the study were diagnosed as having low bone mineral density (BMD) and had recently discontinued HRT. They were randomized to receive either a daily dose of 10 mg of alendronate sodium or matching placebo. The main outcome measures were spine, hip, and total body BMD; biochemical markers of bone turnover; and tolerability.Alendronate treatment was associated with a 2.3% mean increase (95% confidence interval [CI], 1.7%-3.0%) in spine BMD compared with a mean loss of 3.2% (95% CI, - 4.6% to - 1.7%) in patients receiving placebo, for a difference of 5.5% (95% CI, 4.2%-6.8%) between alendronate and placebo. Greater hip and total body BMD preservation was also observed with alendronate use. Bone turnover decreased significantly with alendronate (bone-specific alkaline phosphatase levels decreased by 20% and urinary N-telopeptide/creatinine ratio by 47%), but increased in the placebo group (by 18% and 36%, respectively). Alendronate was well tolerated, with no increase in adverse events compared with placebo.A high rate of bone loss was observed in the first 12 to 15 months after discontinuation of HRT in postmenopausal women with low BMD. Treatment with alendronate increased or maintained both spine and hip BMD and prevented the increase in bone resorption seen with withdrawal of HRT in this population." @default.
• W2073420242 created "2016-06-24" @default.
• W2073420242 creator A5000902840 @default.
• W2073420242 creator A5004980959 @default.
• W2073420242 creator A5019806176 @default.
• W2073420242 creator A5033876965 @default.
• W2073420242 creator A5035082582 @default.
• W2073420242 creator A5066827451 @default.
• W2073420242 creator A5075084513 @default.
• W2073420242 creator A5090139273 @default.
• W2073420242 date "2003-04-14" @default.
• W2073420242 modified "2023-10-01" @default.
• W2073420242 title "Alendronate Prevents Loss of Bone Density Associated With Discontinuation of Hormone Replacement Therapy" @default.
• W2073420242 cites W1561293749 @default.
• W2073420242 cites W1593442063 @default.
• W2073420242 cites W1963970016 @default.
• W2073420242 cites W1987401403 @default.
• W2073420242 cites W2005298224 @default.
• W2073420242 cites W2005374613 @default.
• W2073420242 cites W2016677964 @default.
• W2073420242 cites W2024975817 @default.
• W2073420242 cites W2033237298 @default.
• W2073420242 cites W2034238658 @default.
• W2073420242 cites W2035593552 @default.
• W2073420242 cites W2039839937 @default.
• W2073420242 cites W2047486987 @default.
• W2073420242 cites W2049173150 @default.
• W2073420242 cites W2050406935 @default.
• W2073420242 cites W2069798869 @default.
• W2073420242 cites W2078406992 @default.
• W2073420242 cites W2097506722 @default.
• W2073420242 cites W2104949625 @default.
• W2073420242 cites W2110993073 @default.
• W2073420242 cites W2113264115 @default.
• W2073420242 cites W2121829164 @default.
• W2073420242 cites W2125678264 @default.
• W2073420242 cites W2142820105 @default.
• W2073420242 cites W2151649765 @default.
• W2073420242 cites W2153009489 @default.
• W2073420242 cites W2172119280 @default.
• W2073420242 cites W2179632721 @default.
• W2073420242 cites W2321227665 @default.
• W2073420242 cites W2329402624 @default.
• W2073420242 cites W2332056249 @default.
• W2073420242 cites W2469416225 @default.
• W2073420242 cites W95785129 @default.
• W2073420242 doi "https://doi.org/10.1001/archinte.163.7.789" @default.
• W2073420242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12695269" @default.
• W2073420242 hasPublicationYear "2003" @default.
• W2073420242 type Work @default.
• W2073420242 sameAs 2073420242 @default.
• W2073420242 citedByCount "64" @default.
• W2073420242 countsByYear W20734202422012 @default.
• W2073420242 countsByYear W20734202422013 @default.
• W2073420242 countsByYear W20734202422016 @default.
• W2073420242 countsByYear W20734202422017 @default.
• W2073420242 countsByYear W20734202422018 @default.
• W2073420242 countsByYear W20734202422019 @default.
• W2073420242 countsByYear W20734202422020 @default.
• W2073420242 countsByYear W20734202422021 @default.
• W2073420242 countsByYear W20734202422022 @default.
• W2073420242 countsByYear W20734202422023 @default.
• W2073420242 crossrefType "journal-article" @default.
• W2073420242 hasAuthorship W2073420242A5000902840 @default.
• W2073420242 hasAuthorship W2073420242A5004980959 @default.
• W2073420242 hasAuthorship W2073420242A5019806176 @default.
• W2073420242 hasAuthorship W2073420242A5033876965 @default.
• W2073420242 hasAuthorship W2073420242A5035082582 @default.
• W2073420242 hasAuthorship W2073420242A5066827451 @default.
• W2073420242 hasAuthorship W2073420242A5075084513 @default.
• W2073420242 hasAuthorship W2073420242A5090139273 @default.
• W2073420242 hasBestOaLocation W20734202421 @default.
• W2073420242 hasConcept C126322002 @default.
• W2073420242 hasConcept C126894567 @default.
• W2073420242 hasConcept C141071460 @default.
• W2073420242 hasConcept C142724271 @default.
• W2073420242 hasConcept C170033053 @default.
• W2073420242 hasConcept C197934379 @default.
• W2073420242 hasConcept C204787440 @default.
• W2073420242 hasConcept C27081682 @default.
• W2073420242 hasConcept C2776541429 @default.
• W2073420242 hasConcept C2776886416 @default.
• W2073420242 hasConcept C2778375690 @default.
• W2073420242 hasConcept C2778715236 @default.
• W2073420242 hasConcept C2779279991 @default.
• W2073420242 hasConcept C2779329777 @default.
• W2073420242 hasConcept C2779809032 @default.
• W2073420242 hasConcept C2780159708 @default.
• W2073420242 hasConcept C71924100 @default.
• W2073420242 hasConceptScore W2073420242C126322002 @default.
• W2073420242 hasConceptScore W2073420242C126894567 @default.
• W2073420242 hasConceptScore W2073420242C141071460 @default.
• W2073420242 hasConceptScore W2073420242C142724271 @default.
• W2073420242 hasConceptScore W2073420242C170033053 @default.
• W2073420242 hasConceptScore W2073420242C197934379 @default.
• W2073420242 hasConceptScore W2073420242C204787440 @default.
• W2073420242 hasConceptScore W2073420242C27081682 @default.
• W2073420242 hasConceptScore W2073420242C2776541429 @default.

• next