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• W2073420729 abstract "A stable mutant of human leukemia CCRF/CEM cells has recently been isolated which is transport resistant for methotrexate (MTX). Encapsulation of MTX in cationic unilamellar liposomes increased the association of the drug 5-fold with the sensitive, and 50-fold with the resistant, cells as compared to the uptake of free drug. The liposome-mediated associations of MTX with sensitive and transport deficient cell lines were similar. Cytostatic studies demonstrated that liposome encapsulation increased MTX activity 4-fold towards the transport resistant cell line. The addition of cholesterol to the vesicles decreased their effectiveness. A 4-fold increase in drug sensitivity due to encapsulation may allow such transport resistant tumor cells to become responsive to chemotherapeutic doses of MTX which are currently feasible in human clinical protocols." @default.
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• W2073420729 date "1982-02-01" @default.
• W2073420729 modified "2023-10-11" @default.
• W2073420729 title "Liposome encapsulation enhancement of methotrexate sensitivity in a transport resistant human leukemic cell line" @default.
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• W2073420729 doi "https://doi.org/10.1016/0006-2952(82)90157-5" @default.
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