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• W2073424517 abstract "A single large dose (100 mg/kg, s.c.) of methamphetamine (MA) is known to exert neurotoxic effects on dopaminergic neurons. The potency at which a series of dopamine (DA) uptake inhibitors blocked MA-induced neostriatal depletions (amfonelic acid (AFA) ≫ mazindol (MAZ) ⩾ bupropion (BUP) > benztropine (BENZ)) was similar to their potency at blocking 6-hydroxydopamine (6-OHDA) neurotoxicity in rats. Amfonelic acid was able to block long-term neostriatal DA depletions when given 8 h, but not 16 h, after a single large MA dose. These results suggest that an intact and functional DA uptake site is necessary for the development of MA-induced long-term DA depletions." @default.
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• W2073424517 date "1990-04-01" @default.
• W2073424517 modified "2023-10-14" @default.
• W2073424517 title "Dopamine uptake inhibitors block long-term neurotoxic effects of methamphetamine upon dopaminergic neurons" @default.
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• W2073424517 doi "https://doi.org/10.1016/0006-8993(90)90467-p" @default.
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