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• W2073436434 abstract "Microcirculatory derangements caused by ischemia and reperfusion (I/R) play a pivotal role in acute and graft pancreatitis. The inducible enzyme heme oxygenase 1 (HO-1) has been shown to decrease I/R injury by modulation of capillary perfusion in other organs. It was the aim of this study to evaluate the effect of HO-1 induction on pancreatic microcirculation after I/R.Rats were randomized into 4 groups: (1) sham controls; (2) 1-hour ischemia and 2-hour reperfusion (I/R); (3) I/R + cobalt protoporphyrin (CoPP), an HO-1 inducer; and (4) I/R + CoPP + tin protoporphyrin, an HO inhibitor. Functional capillary density (FCD) and leukocyte endothelium interaction were analyzed using intravital microscopy during reperfusion. Expression of HO-1 mRNA, HO-1 protein, and HO activity were assessed by Northern blot, Western blot, and an HO activity assay.Functional capillary density decreased significantly in the I/R group as compared with sham controls. Cobalt protoporphyrin treatment increased FCD to control values. In contrast, HO inhibition in CoPP-pretreated animals lowered FCD and increased leukocyte endothelium interaction significantly. Cobalt protoporphyrin administration increased HO-1 mRNA, protein, and HO activity, whereas activity of the enzyme was reduced after injection of tin protoporphyrin.Heme oxygenase 1 plays a beneficial role in pancreatic microcirculatory derangements after I/R. This could be of therapeutic relevance after pancreas transplantation and other forms of postischemic pancreatitis." @default.
• W2073436434 created "2016-06-24" @default.
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• W2073436434 date "2008-05-01" @default.
• W2073436434 modified "2023-10-18" @default.
• W2073436434 title "Protective Role of Heme Oxygenase-1 in Pancreatic Microcirculatory Dysfunction After Ischemia/Reperfusion in Rats" @default.
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• W2073436434 doi "https://doi.org/10.1097/mpa.0b013e31815ceb0e" @default.
• W2073436434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18437084" @default.
• W2073436434 hasPublicationYear "2008" @default.
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