FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073436904> ?p ?o ?g. }

• W2073436904 endingPage "10506" @default.
• W2073436904 startingPage "10498" @default.
• W2073436904 abstract "The RNA- and DNA-dependent DNA polymerase activities of two point mutants of HIV-1 reverse transcriptase lacking ribonuclease H activity have been compared to the wild-type enzyme activities using substrates consisting of an oligodeoxynucleotide primer hybridized to either a RNA or a DNA template. The RNase H phenotype had a negligible effect on the steady-state kinetics and processivity of reverse transcription of a homopolymer template-primer [poly(A).oligo(dT)]. However, analysis of the distribution of DNA products indicated that the ability of the mutants to reverse-transcribe a specifically primed 345-nucleotide heteropolymeric RNA template derived from the gag region of HIV-1 was impaired relative to the wild-type enzyme. Although the wild-type and mutant enzymes shared the same pause sites of synthesis along the RNA template, certain prematurely terminated nascent primer chains were poorly extended by the mutant enzymes and hence accumulated, suggesting that a catalytically functional RNase domain facilitated reinitiation of DNA synthesis at specific pause sites along a heteropolymer template. In contrast, the processivity and product distribution of DNA synthesis directed by a heteropolymer gag DNA template of the same nucleotide sequence were not significantly influenced by the RNase H phenotype of the mutants." @default.
• W2073436904 created "2016-06-24" @default.
• W2073436904 creator A5003541400 @default.
• W2073436904 creator A5042007756 @default.
• W2073436904 creator A5072243737 @default.
• W2073436904 date "1991-10-01" @default.
• W2073436904 modified "2023-09-26" @default.
• W2073436904 title "Analysis of the RNA- and DNA-dependent DNA polymerase activities of point mutants of HIV-1 reverse transcriptase lacking ribonuclease H activity" @default.
• W2073436904 cites W1487143054 @default.
• W2073436904 cites W1515069870 @default.
• W2073436904 cites W1557097517 @default.
• W2073436904 cites W1571463280 @default.
• W2073436904 cites W1587208028 @default.
• W2073436904 cites W1591988375 @default.
• W2073436904 cites W1602454738 @default.
• W2073436904 cites W1693107265 @default.
• W2073436904 cites W1761225178 @default.
• W2073436904 cites W1970850106 @default.
• W2073436904 cites W1976439804 @default.
• W2073436904 cites W1976754511 @default.
• W2073436904 cites W1994163120 @default.
• W2073436904 cites W1994777317 @default.
• W2073436904 cites W1999103713 @default.
• W2073436904 cites W2008408466 @default.
• W2073436904 cites W2008984149 @default.
• W2073436904 cites W2009571668 @default.
• W2073436904 cites W2015558688 @default.
• W2073436904 cites W2018893626 @default.
• W2073436904 cites W2025208167 @default.
• W2073436904 cites W2028094900 @default.
• W2073436904 cites W2029161127 @default.
• W2073436904 cites W2038776945 @default.
• W2073436904 cites W2052306401 @default.
• W2073436904 cites W2067108483 @default.
• W2073436904 cites W2067354942 @default.
• W2073436904 cites W2079457507 @default.
• W2073436904 cites W2094835280 @default.
• W2073436904 cites W2103947911 @default.
• W2073436904 cites W2123666769 @default.
• W2073436904 cites W265539035 @default.
• W2073436904 cites W4850913 @default.
• W2073436904 doi "https://doi.org/10.1021/bi00107a019" @default.
• W2073436904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1718422" @default.
• W2073436904 hasPublicationYear "1991" @default.
• W2073436904 type Work @default.
• W2073436904 sameAs 2073436904 @default.
• W2073436904 citedByCount "43" @default.
• W2073436904 countsByYear W20734369042012 @default.
• W2073436904 countsByYear W20734369042013 @default.
• W2073436904 countsByYear W20734369042015 @default.
• W2073436904 crossrefType "journal-article" @default.
• W2073436904 hasAuthorship W2073436904A5003541400 @default.
• W2073436904 hasAuthorship W2073436904A5042007756 @default.
• W2073436904 hasAuthorship W2073436904A5072243737 @default.
• W2073436904 hasConcept C104317684 @default.
• W2073436904 hasConcept C10879258 @default.
• W2073436904 hasConcept C129312508 @default.
• W2073436904 hasConcept C131140672 @default.
• W2073436904 hasConcept C143065580 @default.
• W2073436904 hasConcept C153911025 @default.
• W2073436904 hasConcept C156719811 @default.
• W2073436904 hasConcept C178790620 @default.
• W2073436904 hasConcept C185592680 @default.
• W2073436904 hasConcept C194830204 @default.
• W2073436904 hasConcept C2756471 @default.
• W2073436904 hasConcept C2777563447 @default.
• W2073436904 hasConcept C2778976237 @default.
• W2073436904 hasConcept C2910803801 @default.
• W2073436904 hasConcept C552990157 @default.
• W2073436904 hasConcept C55493867 @default.
• W2073436904 hasConcept C67705224 @default.
• W2073436904 hasConcept C69766542 @default.
• W2073436904 hasConcept C82381507 @default.
• W2073436904 hasConcept C86803240 @default.
• W2073436904 hasConceptScore W2073436904C104317684 @default.
• W2073436904 hasConceptScore W2073436904C10879258 @default.
• W2073436904 hasConceptScore W2073436904C129312508 @default.
• W2073436904 hasConceptScore W2073436904C131140672 @default.
• W2073436904 hasConceptScore W2073436904C143065580 @default.
• W2073436904 hasConceptScore W2073436904C153911025 @default.
• W2073436904 hasConceptScore W2073436904C156719811 @default.
• W2073436904 hasConceptScore W2073436904C178790620 @default.
• W2073436904 hasConceptScore W2073436904C185592680 @default.
• W2073436904 hasConceptScore W2073436904C194830204 @default.
• W2073436904 hasConceptScore W2073436904C2756471 @default.
• W2073436904 hasConceptScore W2073436904C2777563447 @default.
• W2073436904 hasConceptScore W2073436904C2778976237 @default.
• W2073436904 hasConceptScore W2073436904C2910803801 @default.
• W2073436904 hasConceptScore W2073436904C552990157 @default.
• W2073436904 hasConceptScore W2073436904C55493867 @default.
• W2073436904 hasConceptScore W2073436904C67705224 @default.
• W2073436904 hasConceptScore W2073436904C69766542 @default.
• W2073436904 hasConceptScore W2073436904C82381507 @default.
• W2073436904 hasConceptScore W2073436904C86803240 @default.
• W2073436904 hasIssue "43" @default.
• W2073436904 hasLocation W20734369041 @default.
• W2073436904 hasLocation W20734369042 @default.
• W2073436904 hasOpenAccess W2073436904 @default.

• next