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- W2073441737 abstract "Hypoxic ischemic encephalopathy (HIE), despite advances in diagnosis and treatment, is still a major problem which leads to increased morbidity and mortality. Previous studies suggested that inflammatory cycle induced by hypoxia and ischemia play a role in the pathogenesis of HIE. In this study we investigated the relationship between HIE and inflammatory response by measuring IL-6, IL-18 and hsCRP levels in newborn infants with HIE. All term infants who have diagnosed HIE, delivered in our institute between study period were included in the study. Infants were classificated to stage I, stage II and stage III according to clinical findings (Sarnat & Sarnat classification were used). IL-6, IL-18 and hsCRP levels were determined in blood samples; in the first 24 hours (early period), and 48–72 hours (late period) respectively. 30 patients were included in the study. We found that IL-6 levels were decreased and IL-18 and hsCRP were increased in the late period. Increased levels of IL-18 and hsCRP defined as statistically significant (p < 0.01, p < 0.05 respectively). Patients who died had higher levels of IL-18 in the late period. High serum IL-18 and hsCRP levels in the late period are associated with advanced stages of HIE." @default.
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- W2073441737 date "2014-09-01" @default.
- W2073441737 modified "2023-09-26" @default.
- W2073441737 title "5ICCN_026: The IL-6, IL-18 and hsCRP levels of the newborn infants with hypoxic ischemic encephalopathy" @default.
- W2073441737 doi "https://doi.org/10.1016/s0378-3782(14)50050-3" @default.
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