Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073443118> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2073443118 endingPage "187" @default.
- W2073443118 startingPage "183" @default.
- W2073443118 abstract "Objective To describe a patient with tuberous xanthomas and high levels of cholesterol and triglycerides, who was found to have type III hyperlipoproteinemia (HLP) and a rare apolipoprotein E (apoE) mutation. Methods We present a case report with extensive clinical, laboratory, and genetic documentation. Results A 33-year-old African American man presented for evaluation of hypertriglyceridemia. His medical history was remarkable for schizophrenia necessitating ongoing olanzapine therapy for the past 6 years. A few months after olanzapine treatment was begun, he noted the development of nontender, firm, papular skin lesions on his elbows and knees. His family history was negative for lipid disorders or premature vascular disease. Physical examination revealed the presence of prominent tuberous xanthomas on both elbows and knees. Results of a lipid panel demonstrated a total cholesterol level of 374 mg/dL (9.7 mmol/L) and triglycerides of 828 mg/dL (9.3 mmol/L). A work-up for causes of secondary hypertriglyceridemia was negative. Results of apoE genotyping by a commercial laboratory showed the E3/E3 genotype, based on gene sequencing at codons 112 and 158. Because the skin lesions were typical for type III HLP, his entire apoE gene was sequenced. This analysis revealed an apoE2/E2 (arginine 145 to cysteine) mutation, previously reported to be a rare cause of type III HLP in 5 patients of African descent. Triglyceride-lowering therapy with gemfibrozil was initiated, in addition to lifestyle modification. At follow-up several months later, total cholesterol was 276 mg/dL (7.14 mmol/L) and triglycerides were 479 mg/dL (5.41 mmol/L). Conclusion We speculate that olanzapine therapy, with its known metabolic side effects, exacerbated this patient’s underlying lipoprotein metabolic abnormality. To our knowledge, this is the first report of an association between olanzapine therapy and tuberous xanthomas and the sixth report of this rare apoE2/E2 (arginine 145 to cysteine) mutation in the literature. (Endocr Pract. 2006;12: 183-187)" @default.
- W2073443118 created "2016-06-24" @default.
- W2073443118 creator A5062468141 @default.
- W2073443118 creator A5079787971 @default.
- W2073443118 date "2006-03-01" @default.
- W2073443118 modified "2023-09-24" @default.
- W2073443118 title "Tuberous Xanthomas Associated with Olanzapine Therapy and Hypertriglyceridemia in the Setting of a Rare Apolipoprotein E Mutation" @default.
- W2073443118 cites W1577502861 @default.
- W2073443118 cites W1582053154 @default.
- W2073443118 cites W1971583342 @default.
- W2073443118 cites W1979447150 @default.
- W2073443118 cites W1980407853 @default.
- W2073443118 cites W1991196517 @default.
- W2073443118 cites W2018285216 @default.
- W2073443118 cites W2020737544 @default.
- W2073443118 cites W2026144211 @default.
- W2073443118 cites W2039158755 @default.
- W2073443118 cites W2062218710 @default.
- W2073443118 cites W2073697159 @default.
- W2073443118 cites W2081151510 @default.
- W2073443118 cites W2082548951 @default.
- W2073443118 cites W2119332560 @default.
- W2073443118 cites W2128153531 @default.
- W2073443118 cites W2141041965 @default.
- W2073443118 cites W4233622592 @default.
- W2073443118 cites W4294235448 @default.
- W2073443118 doi "https://doi.org/10.4158/ep.12.2.183" @default.
- W2073443118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16690468" @default.
- W2073443118 hasPublicationYear "2006" @default.
- W2073443118 type Work @default.
- W2073443118 sameAs 2073443118 @default.
- W2073443118 citedByCount "9" @default.
- W2073443118 countsByYear W20734431182012 @default.
- W2073443118 countsByYear W20734431182013 @default.
- W2073443118 countsByYear W20734431182014 @default.
- W2073443118 countsByYear W20734431182016 @default.
- W2073443118 countsByYear W20734431182017 @default.
- W2073443118 countsByYear W20734431182023 @default.
- W2073443118 crossrefType "journal-article" @default.
- W2073443118 hasAuthorship W2073443118A5062468141 @default.
- W2073443118 hasAuthorship W2073443118A5079787971 @default.
- W2073443118 hasConcept C118552586 @default.
- W2073443118 hasConcept C126322002 @default.
- W2073443118 hasConcept C134018914 @default.
- W2073443118 hasConcept C142724271 @default.
- W2073443118 hasConcept C2776412080 @default.
- W2073443118 hasConcept C2776619155 @default.
- W2073443118 hasConcept C2776919658 @default.
- W2073443118 hasConcept C2777887477 @default.
- W2073443118 hasConcept C2778163477 @default.
- W2073443118 hasConcept C2778670441 @default.
- W2073443118 hasConcept C2778913445 @default.
- W2073443118 hasConcept C2779134260 @default.
- W2073443118 hasConcept C57089818 @default.
- W2073443118 hasConcept C62746215 @default.
- W2073443118 hasConcept C71924100 @default.
- W2073443118 hasConcept C90924648 @default.
- W2073443118 hasConceptScore W2073443118C118552586 @default.
- W2073443118 hasConceptScore W2073443118C126322002 @default.
- W2073443118 hasConceptScore W2073443118C134018914 @default.
- W2073443118 hasConceptScore W2073443118C142724271 @default.
- W2073443118 hasConceptScore W2073443118C2776412080 @default.
- W2073443118 hasConceptScore W2073443118C2776619155 @default.
- W2073443118 hasConceptScore W2073443118C2776919658 @default.
- W2073443118 hasConceptScore W2073443118C2777887477 @default.
- W2073443118 hasConceptScore W2073443118C2778163477 @default.
- W2073443118 hasConceptScore W2073443118C2778670441 @default.
- W2073443118 hasConceptScore W2073443118C2778913445 @default.
- W2073443118 hasConceptScore W2073443118C2779134260 @default.
- W2073443118 hasConceptScore W2073443118C57089818 @default.
- W2073443118 hasConceptScore W2073443118C62746215 @default.
- W2073443118 hasConceptScore W2073443118C71924100 @default.
- W2073443118 hasConceptScore W2073443118C90924648 @default.
- W2073443118 hasIssue "2" @default.
- W2073443118 hasLocation W20734431181 @default.
- W2073443118 hasOpenAccess W2073443118 @default.
- W2073443118 hasPrimaryLocation W20734431181 @default.
- W2073443118 hasRelatedWork W2014778364 @default.
- W2073443118 hasRelatedWork W2039250890 @default.
- W2073443118 hasRelatedWork W2073443118 @default.
- W2073443118 hasRelatedWork W2099385407 @default.
- W2073443118 hasRelatedWork W2132485488 @default.
- W2073443118 hasRelatedWork W2154511047 @default.
- W2073443118 hasRelatedWork W2155242563 @default.
- W2073443118 hasRelatedWork W2155947160 @default.
- W2073443118 hasRelatedWork W2162750209 @default.
- W2073443118 hasRelatedWork W3177322528 @default.
- W2073443118 hasVolume "12" @default.
- W2073443118 isParatext "false" @default.
- W2073443118 isRetracted "false" @default.
- W2073443118 magId "2073443118" @default.
- W2073443118 workType "article" @default.