FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073446156> ?p ?o ?g. }

• W2073446156 endingPage "1699" @default.
• W2073446156 startingPage "1693" @default.
• W2073446156 abstract "We have recently identified disorganized muscle protein-1 (DIM-1) in one of the proinflammatory fractions of the human filaria Brugia malayi adult worm. The present study was undertaken to characterize B. malayi DIM-1 (DIM-1bm) and explore its vaccine potential. In this study we cloned and expressed the DIM-1bm gene, investigated its sequence homology with other nematodes, constructed in silico structural model, purified the recombinant DIM-1bm (rDIM-1bm) protein, and studied the effect of immunization with rDIM-1bm on the establishment of B. malayi infection in Mastomys coucha. DIM-1bm showed similarity with DIM-1 of Caenorhabditis elegans, Ascaris suum and Loa loa. Structural modeling revealed three immunoglobulin domains in DIM-1bm indicating that it is a member of immunoglobulin superfamily (IgSF) and ‘blastn’ results showed that DIM-1bm coding sequence (CDS) have almost no homology with human and mouse nucleotide sequences. Immunization with rDIM-1bm partially protected M. coucha against establishment of infection as inferred by a low recovery of microfilariae (37–64%) and parasite burden (∼50%). The enhanced activity of macrophages, and IFN-γ and NO responses, and elevated levels of specific IgG, IgG1, IgG2a and IgG2b correlated with parasitological findings. This is the first report on cloning, expression, structural modeling and purification of rDIM-1bm and its ability to partially prevent establishment of B. malayi infection. DIM-1bm's almost complete lack of homology with the human counterpart makes it an attractive protein for exploring its vaccine potential." @default.
• W2073446156 created "2016-06-24" @default.
• W2073446156 creator A5012744982 @default.
• W2073446156 creator A5035809373 @default.
• W2073446156 creator A5045277184 @default.
• W2073446156 creator A5064881436 @default.
• W2073446156 creator A5073707664 @default.
• W2073446156 creator A5080134794 @default.
• W2073446156 date "2014-03-01" @default.
• W2073446156 modified "2023-10-14" @default.
• W2073446156 title "Disorganized muscle protein-1 (DIM-1) of filarial parasite Brugia malayi: cDNA cloning, expression, purification, structural modeling and its potential as vaccine candidate for human filarial infection" @default.
• W2073446156 cites W1607931568 @default.
• W2073446156 cites W1964457244 @default.
• W2073446156 cites W1971623457 @default.
• W2073446156 cites W1993158258 @default.
• W2073446156 cites W1994069021 @default.
• W2073446156 cites W1994292945 @default.
• W2073446156 cites W2005087399 @default.
• W2073446156 cites W2016278466 @default.
• W2073446156 cites W2018457944 @default.
• W2073446156 cites W2030140262 @default.
• W2073446156 cites W2040975103 @default.
• W2073446156 cites W2052582884 @default.
• W2073446156 cites W2059811549 @default.
• W2073446156 cites W2061353821 @default.
• W2073446156 cites W2064688121 @default.
• W2073446156 cites W2065606340 @default.
• W2073446156 cites W2066336342 @default.
• W2073446156 cites W2067559833 @default.
• W2073446156 cites W2073023385 @default.
• W2073446156 cites W2082004237 @default.
• W2073446156 cites W2088893094 @default.
• W2073446156 cites W2092998235 @default.
• W2073446156 cites W2094974688 @default.
• W2073446156 cites W2104045394 @default.
• W2073446156 cites W2105439272 @default.
• W2073446156 cites W2105454394 @default.
• W2073446156 cites W2107728988 @default.
• W2073446156 cites W2110564812 @default.
• W2073446156 cites W2120230220 @default.
• W2073446156 cites W2129514426 @default.
• W2073446156 cites W2137450588 @default.
• W2073446156 cites W2155354639 @default.
• W2073446156 cites W2158714788 @default.
• W2073446156 cites W2162801432 @default.
• W2073446156 doi "https://doi.org/10.1016/j.vaccine.2014.01.064" @default.
• W2073446156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24513011" @default.
• W2073446156 hasPublicationYear "2014" @default.
• W2073446156 type Work @default.
• W2073446156 sameAs 2073446156 @default.
• W2073446156 citedByCount "13" @default.
• W2073446156 countsByYear W20734461562017 @default.
• W2073446156 countsByYear W20734461562018 @default.
• W2073446156 countsByYear W20734461562019 @default.
• W2073446156 countsByYear W20734461562020 @default.
• W2073446156 countsByYear W20734461562021 @default.
• W2073446156 countsByYear W20734461562022 @default.
• W2073446156 crossrefType "journal-article" @default.
• W2073446156 hasAuthorship W2073446156A5012744982 @default.
• W2073446156 hasAuthorship W2073446156A5035809373 @default.
• W2073446156 hasAuthorship W2073446156A5045277184 @default.
• W2073446156 hasAuthorship W2073446156A5064881436 @default.
• W2073446156 hasAuthorship W2073446156A5073707664 @default.
• W2073446156 hasAuthorship W2073446156A5080134794 @default.
• W2073446156 hasConcept C104317684 @default.
• W2073446156 hasConcept C153911025 @default.
• W2073446156 hasConcept C159047783 @default.
• W2073446156 hasConcept C159654299 @default.
• W2073446156 hasConcept C165901193 @default.
• W2073446156 hasConcept C187882448 @default.
• W2073446156 hasConcept C203014093 @default.
• W2073446156 hasConcept C2775848585 @default.
• W2073446156 hasConcept C2777629521 @default.
• W2073446156 hasConcept C40767141 @default.
• W2073446156 hasConcept C54355233 @default.
• W2073446156 hasConcept C86803240 @default.
• W2073446156 hasConceptScore W2073446156C104317684 @default.
• W2073446156 hasConceptScore W2073446156C153911025 @default.
• W2073446156 hasConceptScore W2073446156C159047783 @default.
• W2073446156 hasConceptScore W2073446156C159654299 @default.
• W2073446156 hasConceptScore W2073446156C165901193 @default.
• W2073446156 hasConceptScore W2073446156C187882448 @default.
• W2073446156 hasConceptScore W2073446156C203014093 @default.
• W2073446156 hasConceptScore W2073446156C2775848585 @default.
• W2073446156 hasConceptScore W2073446156C2777629521 @default.
• W2073446156 hasConceptScore W2073446156C40767141 @default.
• W2073446156 hasConceptScore W2073446156C54355233 @default.
• W2073446156 hasConceptScore W2073446156C86803240 @default.
• W2073446156 hasIssue "15" @default.
• W2073446156 hasLocation W20734461561 @default.
• W2073446156 hasLocation W20734461562 @default.
• W2073446156 hasOpenAccess W2073446156 @default.
• W2073446156 hasPrimaryLocation W20734461561 @default.
• W2073446156 hasRelatedWork W2338137066 @default.
• W2073446156 hasRelatedWork W2350146650 @default.
• W2073446156 hasRelatedWork W2363249581 @default.
• W2073446156 hasRelatedWork W2373690171 @default.
• W2073446156 hasRelatedWork W2376921901 @default.

• next