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• W2073448942 abstract "There are claims by herbal practitioners in Nigeria that the aqueous root decoction of Dalbergia saxatilis (DS) produces sleep as a consequence of its use in anxiety and tension. Moreover, some scientific evidence suggests a link between epilepsy and anxiety. We have reported the sedative and anti-convulsant effects of DS. In this study, the anxiolytic effect of DS was investigated using the Elevated Plus Maze (EPM) and Y-Maze (YM) models of anxiety. DS (50, 100 or 200mg/kg), diazepam (1mg/kg) or distilled water was administered orally, 30min or 90 min. before performing the tests in mice. The cumulative time spent in open and closed arms was recorded within 5 min. To test for the muscle relaxant effect, DS (50, 100 or 200mg/kg), diazepam (1mg/kg) or distilled water was given orally, 30min before subjecting mice to various modified models such as Chimney, Inclined-screen, Traction and Climbing tests. Results showed significant increases in cumulative time spent in open arms when test was carried out 30min post-treatment with DS, but spent longer time than those given diazepam when test was carried out at 90min post-treatment in the open arms of both EPM and YM. A significant dose-related decrease in muscle tone was shown by the Chimney, Inclined screen and Climbing tests, but not in the Traction test. The results suggest that DS has anxiolytic and muscle-relaxant activities. Key Words: Dalbergia saxatilis, anxiolytic, muscle-relaxant, climbing test, elevated plus maze, chimney test. Resume Il existe des affirmations parmis les trado-therapeuts du Nigeria que les concoctions acqueses de la racine de Dalbergia saxatilis (DS) produisent le someille comme consequence de son utilisation dans l'angoisse et la tension. De plus des evidences scientifiques sugere un lien entre l'angoise et l'epilepsy. Nous avons rapporte l'effet sedative et anticonvulsant du DS. Dans cette etude l'effet anxiolitique a ete examine utilisant des”elevated plus maze”(EPM) et Y maze (YM) des models de l'angoisse. DS (50,100,200mg/kg),diazepam(1mg/kg)ou de l'eau distillee etait administre orallement, 30min,90min avant le debut des test sur des souris. Le temps cummulatif mis dans l'ouverture et la fermeture des bras etait enregistre en 5min. pour tester l'effet relaxant des muscles, DS (50,100, 200mg/kg), diazepam (1mg/kg) ou de l'eau distillee etait administre orallement avant de soumettre les souris aux different models modifier telque:”chimney”, ecrant incline,traction et le test de grimpage.les resultats ont montre une augmentation significative du temps cummulatif mis dans l'ouverture et la fermeture des bras.quand les tests etaient conduite 30min post traitement avec le DS,mais mettant plus de temps dans l'ouverture et la fermeture des bras que ce qui ont recut du diazepam 90min apres taitement en EPM et YM. Une reduction du tonus musculaire significative ce a dose dependente on ete demontree par le model”chimney”,ecrant incline, et le test de grimpage mais pas dans le test de traction. Les resultat demontre que le DS a une activitee musculaire relaxante et anxiolitique. Mot cles: Dalbergia saxatilis, relaxant musculaire, anxiolitique, test de grimpage, ”elevate plus maze”, ”chimney test” West Afr. J. Pharmacol. Drug Res. Vol.19 (1&2) 2003: 42-46" @default.
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• W2073448942 date "2004-09-30" @default.
• W2073448942 modified "2023-10-18" @default.
• W2073448942 title "Anxiolytic and Muscle-Relaxant Activities of <i>Dalbergia saxatilis</i>" @default.
• W2073448942 doi "https://doi.org/10.4314/wajpdr.v19i1.14732" @default.
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