Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073450010> ?p ?o ?g. }
- W2073450010 endingPage "484" @default.
- W2073450010 startingPage "473" @default.
- W2073450010 abstract "A highly NGF-secreting cell line was generated by retroviral transduction of a conditionally immortalized CNS-derived neural progenitor cell line. After transplantation to the nucleus basalis magnocellularis (NBM), the cells continue to express the NGF transgene for at least 10 weeks, producing sufficient NGF to reverse cholinergic neuron atrophy in aged rats and induce cellular hypertrophy in young rats. In cognitively impaired aged rats, transplants of the NGF-secreting cells placed either in the NBM and septum or in only the NBM induced a near-complete reversal of the spatial learning impairment. This was accompanied by a normalization of the size of the cholinergic neurons in the grafted areas. The results demonstrate that locally increased supply of NGF to the basal forebrain cholinergic nuclei has a significant impact on cognitive function and support the usefulness of neural progenitor cells for a long-term localized delivery of neurotrophins to the CNS." @default.
- W2073450010 created "2016-06-24" @default.
- W2073450010 creator A5020781010 @default.
- W2073450010 creator A5047762447 @default.
- W2073450010 creator A5049038086 @default.
- W2073450010 date "1995-08-01" @default.
- W2073450010 modified "2023-10-18" @default.
- W2073450010 title "Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain" @default.
- W2073450010 cites W1507370673 @default.
- W2073450010 cites W1565095682 @default.
- W2073450010 cites W1647778121 @default.
- W2073450010 cites W1840016921 @default.
- W2073450010 cites W1927132367 @default.
- W2073450010 cites W1964490604 @default.
- W2073450010 cites W1969423869 @default.
- W2073450010 cites W1977405586 @default.
- W2073450010 cites W1984795811 @default.
- W2073450010 cites W1987107175 @default.
- W2073450010 cites W1994078063 @default.
- W2073450010 cites W1996932819 @default.
- W2073450010 cites W1999232863 @default.
- W2073450010 cites W2001371439 @default.
- W2073450010 cites W2007022331 @default.
- W2073450010 cites W2013152746 @default.
- W2073450010 cites W2014731769 @default.
- W2073450010 cites W2020083687 @default.
- W2073450010 cites W2028477896 @default.
- W2073450010 cites W2030225581 @default.
- W2073450010 cites W2033410250 @default.
- W2073450010 cites W2037194302 @default.
- W2073450010 cites W2039943037 @default.
- W2073450010 cites W2042169537 @default.
- W2073450010 cites W2044175751 @default.
- W2073450010 cites W2044800631 @default.
- W2073450010 cites W2047945439 @default.
- W2073450010 cites W2048098038 @default.
- W2073450010 cites W2059075043 @default.
- W2073450010 cites W2067761637 @default.
- W2073450010 cites W2084807344 @default.
- W2073450010 cites W2089760529 @default.
- W2073450010 cites W2117120152 @default.
- W2073450010 cites W2127208746 @default.
- W2073450010 cites W2131608302 @default.
- W2073450010 cites W2165097308 @default.
- W2073450010 cites W2169473035 @default.
- W2073450010 cites W2413542168 @default.
- W2073450010 cites W2680076749 @default.
- W2073450010 cites W4294216491 @default.
- W2073450010 doi "https://doi.org/10.1016/0896-6273(95)90051-9" @default.
- W2073450010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7646899" @default.
- W2073450010 hasPublicationYear "1995" @default.
- W2073450010 type Work @default.
- W2073450010 sameAs 2073450010 @default.
- W2073450010 citedByCount "153" @default.
- W2073450010 countsByYear W20734500102012 @default.
- W2073450010 countsByYear W20734500102013 @default.
- W2073450010 countsByYear W20734500102014 @default.
- W2073450010 countsByYear W20734500102015 @default.
- W2073450010 countsByYear W20734500102016 @default.
- W2073450010 countsByYear W20734500102017 @default.
- W2073450010 countsByYear W20734500102018 @default.
- W2073450010 countsByYear W20734500102019 @default.
- W2073450010 countsByYear W20734500102020 @default.
- W2073450010 countsByYear W20734500102021 @default.
- W2073450010 crossrefType "journal-article" @default.
- W2073450010 hasAuthorship W2073450010A5020781010 @default.
- W2073450010 hasAuthorship W2073450010A5047762447 @default.
- W2073450010 hasAuthorship W2073450010A5049038086 @default.
- W2073450010 hasBestOaLocation W20734500101 @default.
- W2073450010 hasConcept C104966671 @default.
- W2073450010 hasConcept C136834591 @default.
- W2073450010 hasConcept C169760540 @default.
- W2073450010 hasConcept C170493617 @default.
- W2073450010 hasConcept C201750760 @default.
- W2073450010 hasConcept C22885893 @default.
- W2073450010 hasConcept C2776287375 @default.
- W2073450010 hasConcept C2778205193 @default.
- W2073450010 hasConcept C2778423431 @default.
- W2073450010 hasConcept C28328180 @default.
- W2073450010 hasConcept C55493867 @default.
- W2073450010 hasConcept C86803240 @default.
- W2073450010 hasConcept C92020748 @default.
- W2073450010 hasConcept C95444343 @default.
- W2073450010 hasConceptScore W2073450010C104966671 @default.
- W2073450010 hasConceptScore W2073450010C136834591 @default.
- W2073450010 hasConceptScore W2073450010C169760540 @default.
- W2073450010 hasConceptScore W2073450010C170493617 @default.
- W2073450010 hasConceptScore W2073450010C201750760 @default.
- W2073450010 hasConceptScore W2073450010C22885893 @default.
- W2073450010 hasConceptScore W2073450010C2776287375 @default.
- W2073450010 hasConceptScore W2073450010C2778205193 @default.
- W2073450010 hasConceptScore W2073450010C2778423431 @default.
- W2073450010 hasConceptScore W2073450010C28328180 @default.
- W2073450010 hasConceptScore W2073450010C55493867 @default.
- W2073450010 hasConceptScore W2073450010C86803240 @default.
- W2073450010 hasConceptScore W2073450010C92020748 @default.
- W2073450010 hasConceptScore W2073450010C95444343 @default.
- W2073450010 hasIssue "2" @default.