FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073451143> ?p ?o ?g. }

• W2073451143 endingPage "5775" @default.
• W2073451143 startingPage "5767" @default.
• W2073451143 abstract "We have performed a three-generation, forward genetic screen to identify recessive mutations that affect the patterning of the peripheral nervous system. Using this assay, we identified Sema3A K108N , a novel loss-of-function allele of Sema3A . Class 3 semaphorins, which include Sema3A, are structurally conserved secreted proteins that play critical roles in the development and function of the nervous system. Sema3A K108N mutant mice phenocopy Sema3A -null mice, and Sema3A K108N protein fails to repel or collapse DRG axons in vitro . K108 is conserved among semaphorins, yet the loss-of-function effects associated with K108N are not the result of impaired expression, secretion, or binding of Sema3A to its high-affinity receptor Neuropilin-1 (Npn-1). Using in silico modeling and mutagenesis of other semaphorin family members, we predict that Sema3A K108N interacts poorly with the Npn-1/PlexA holoreceptor and, thus, interferes with its ability to signal at the growth cone. Therefore, through the use of a forward-genetic screen we have identified a novel allele of Sema3A that provides structural insight into the mechanism of Sema3A/Npn-1/PlexinA signaling." @default.
• W2073451143 created "2016-06-24" @default.
• W2073451143 creator A5028169611 @default.
• W2073451143 creator A5029501084 @default.
• W2073451143 creator A5030863883 @default.
• W2073451143 creator A5043425124 @default.
• W2073451143 creator A5074418694 @default.
• W2073451143 creator A5080334304 @default.
• W2073451143 creator A5018545199 @default.
• W2073451143 date "2010-04-21" @default.
• W2073451143 modified "2023-09-26" @default.
• W2073451143 title "A Forward Genetic Screen in Mice Identifies Sema3A^K108N, which Binds to Neuropilin-1 but Cannot Signal" @default.
• W2073451143 cites W1971858644 @default.
• W2073451143 cites W1975269220 @default.
• W2073451143 cites W1987868279 @default.
• W2073451143 cites W1990983421 @default.
• W2073451143 cites W1996685373 @default.
• W2073451143 cites W2000480493 @default.
• W2073451143 cites W2003432505 @default.
• W2073451143 cites W2003766638 @default.
• W2073451143 cites W2020725045 @default.
• W2073451143 cites W2026828087 @default.
• W2073451143 cites W2047166961 @default.
• W2073451143 cites W2051130488 @default.
• W2073451143 cites W2064173164 @default.
• W2073451143 cites W2068224188 @default.
• W2073451143 cites W2068599628 @default.
• W2073451143 cites W2077515896 @default.
• W2073451143 cites W2086588218 @default.
• W2073451143 cites W2092641793 @default.
• W2073451143 cites W2094426096 @default.
• W2073451143 cites W2115167653 @default.
• W2073451143 cites W2117620907 @default.
• W2073451143 cites W2121467659 @default.
• W2073451143 cites W2131860275 @default.
• W2073451143 cites W2132540199 @default.
• W2073451143 cites W2136641275 @default.
• W2073451143 cites W2156597588 @default.
• W2073451143 cites W4253566969 @default.
• W2073451143 doi "https://doi.org/10.1523/jneurosci.5061-09.2010" @default.
• W2073451143 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2869466" @default.
• W2073451143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20410128" @default.
• W2073451143 hasPublicationYear "2010" @default.
• W2073451143 type Work @default.
• W2073451143 sameAs 2073451143 @default.
• W2073451143 citedByCount "34" @default.
• W2073451143 countsByYear W20734511432012 @default.
• W2073451143 countsByYear W20734511432013 @default.
• W2073451143 countsByYear W20734511432014 @default.
• W2073451143 countsByYear W20734511432015 @default.
• W2073451143 countsByYear W20734511432016 @default.
• W2073451143 countsByYear W20734511432017 @default.
• W2073451143 countsByYear W20734511432018 @default.
• W2073451143 countsByYear W20734511432019 @default.
• W2073451143 countsByYear W20734511432020 @default.
• W2073451143 countsByYear W20734511432021 @default.
• W2073451143 countsByYear W20734511432022 @default.
• W2073451143 crossrefType "journal-article" @default.
• W2073451143 hasAuthorship W2073451143A5018545199 @default.
• W2073451143 hasAuthorship W2073451143A5028169611 @default.
• W2073451143 hasAuthorship W2073451143A5029501084 @default.
• W2073451143 hasAuthorship W2073451143A5030863883 @default.
• W2073451143 hasAuthorship W2073451143A5043425124 @default.
• W2073451143 hasAuthorship W2073451143A5074418694 @default.
• W2073451143 hasAuthorship W2073451143A5080334304 @default.
• W2073451143 hasBestOaLocation W20734511431 @default.
• W2073451143 hasConcept C104317684 @default.
• W2073451143 hasConcept C105951970 @default.
• W2073451143 hasConcept C106420622 @default.
• W2073451143 hasConcept C12387725 @default.
• W2073451143 hasConcept C127716648 @default.
• W2073451143 hasConcept C132538176 @default.
• W2073451143 hasConcept C143065580 @default.
• W2073451143 hasConcept C167734588 @default.
• W2073451143 hasConcept C169760540 @default.
• W2073451143 hasConcept C170493617 @default.
• W2073451143 hasConcept C207177822 @default.
• W2073451143 hasConcept C2775905019 @default.
• W2073451143 hasConcept C2776805952 @default.
• W2073451143 hasConcept C2777025900 @default.
• W2073451143 hasConcept C34425596 @default.
• W2073451143 hasConcept C502942594 @default.
• W2073451143 hasConcept C54355233 @default.
• W2073451143 hasConcept C69125201 @default.
• W2073451143 hasConcept C86803240 @default.
• W2073451143 hasConcept C95444343 @default.
• W2073451143 hasConceptScore W2073451143C104317684 @default.
• W2073451143 hasConceptScore W2073451143C105951970 @default.
• W2073451143 hasConceptScore W2073451143C106420622 @default.
• W2073451143 hasConceptScore W2073451143C12387725 @default.
• W2073451143 hasConceptScore W2073451143C127716648 @default.
• W2073451143 hasConceptScore W2073451143C132538176 @default.
• W2073451143 hasConceptScore W2073451143C143065580 @default.
• W2073451143 hasConceptScore W2073451143C167734588 @default.
• W2073451143 hasConceptScore W2073451143C169760540 @default.
• W2073451143 hasConceptScore W2073451143C170493617 @default.
• W2073451143 hasConceptScore W2073451143C207177822 @default.
• W2073451143 hasConceptScore W2073451143C2775905019 @default.

• next