Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073451744> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2073451744 abstract "The purpose of this present study is to clarify adenosine (ADO) metabolism in guinea pig brain slices during simulated ischemia. In slice preparations after decapitation, ADO levels were lowest in slices of the cerebellum (1.2 nmol/mg protein), followed by the superior colliculus (3.4) and highest in the hippocampus (6.4), and the combined concentrations of inosine (Ino) and hypoxanthine (HX) were highest in the cerebellum (5.5), followed by the superior colliculus (3.5) and the hippocampus (1.5). After preincubation with standard medium with oxygen and glucose for 30 min, total ADO levels (tissue ADO plus ADO lost into medium during incubation) decreased to 0.3 in the cerebellum, to 1.3 in the superior colliculus and to 2. 9 in the hippocampus. On the other hand, levels of total Ino and HX increased to 21.1 in the cerebellum, to 14.3 in the hippocampus and to 12.0 in the superior colliculus. To investigate the effect of simulated ischemia on ADO metabolism, preincubated slices were exposed for 10 min in medium deprived of oxygen and glucose. The increases of ADO content after 10 min ischemia were 0.2 in the cerebellum, 1.0 in the superior colliculus and 1.3 in the hippocampus. In contrast, the increases of both Ino and HX concentrations were 2.9 in the cerebellum, 2.2 in the superior colliculus and 1.4 in the hippocampus. The total amount of the increase in ADO, Ino and HX was approximately 3 in all three regions. These results indicate that there are significant differences in the metabolic rate to degrade ADO into Ino and HX in various areas of brain possibly due to differences in adenosine deaminase activity in those areas." @default.
- W2073451744 created "2016-06-24" @default.
- W2073451744 creator A5011775443 @default.
- W2073451744 creator A5018970044 @default.
- W2073451744 creator A5020278626 @default.
- W2073451744 date "1998-03-01" @default.
- W2073451744 modified "2023-09-25" @default.
- W2073451744 title "The effects of simulated ischemia on the levels of adenosine and its metabolites in slices of cerebellum, superior colliculus and hippocampus in the guinea pig—in vitro study" @default.
- W2073451744 cites W1775749144 @default.
- W2073451744 cites W1967471508 @default.
- W2073451744 cites W1971905460 @default.
- W2073451744 cites W1972785991 @default.
- W2073451744 cites W1973293727 @default.
- W2073451744 cites W1976423890 @default.
- W2073451744 cites W1977610115 @default.
- W2073451744 cites W1982473707 @default.
- W2073451744 cites W1990955156 @default.
- W2073451744 cites W1995968643 @default.
- W2073451744 cites W2015880776 @default.
- W2073451744 cites W2022718145 @default.
- W2073451744 cites W2024207498 @default.
- W2073451744 cites W2036758780 @default.
- W2073451744 cites W2046073222 @default.
- W2073451744 cites W2046369833 @default.
- W2073451744 cites W2049161935 @default.
- W2073451744 cites W2049514044 @default.
- W2073451744 cites W2049785746 @default.
- W2073451744 cites W2058835315 @default.
- W2073451744 cites W2073862465 @default.
- W2073451744 cites W2075056521 @default.
- W2073451744 cites W2078522953 @default.
- W2073451744 cites W2113485169 @default.
- W2073451744 cites W211789298 @default.
- W2073451744 doi "https://doi.org/10.1016/s0006-8993(97)01482-0" @default.
- W2073451744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9518623" @default.
- W2073451744 hasPublicationYear "1998" @default.
- W2073451744 type Work @default.
- W2073451744 sameAs 2073451744 @default.
- W2073451744 citedByCount "4" @default.
- W2073451744 crossrefType "journal-article" @default.
- W2073451744 hasAuthorship W2073451744A5011775443 @default.
- W2073451744 hasAuthorship W2073451744A5018970044 @default.
- W2073451744 hasAuthorship W2073451744A5020278626 @default.
- W2073451744 hasConcept C126322002 @default.
- W2073451744 hasConcept C134018914 @default.
- W2073451744 hasConcept C169760540 @default.
- W2073451744 hasConcept C185592680 @default.
- W2073451744 hasConcept C2778815084 @default.
- W2073451744 hasConcept C2779652256 @default.
- W2073451744 hasConcept C2781161787 @default.
- W2073451744 hasConcept C2781416072 @default.
- W2073451744 hasConcept C541997718 @default.
- W2073451744 hasConcept C71924100 @default.
- W2073451744 hasConcept C86803240 @default.
- W2073451744 hasConceptScore W2073451744C126322002 @default.
- W2073451744 hasConceptScore W2073451744C134018914 @default.
- W2073451744 hasConceptScore W2073451744C169760540 @default.
- W2073451744 hasConceptScore W2073451744C185592680 @default.
- W2073451744 hasConceptScore W2073451744C2778815084 @default.
- W2073451744 hasConceptScore W2073451744C2779652256 @default.
- W2073451744 hasConceptScore W2073451744C2781161787 @default.
- W2073451744 hasConceptScore W2073451744C2781416072 @default.
- W2073451744 hasConceptScore W2073451744C541997718 @default.
- W2073451744 hasConceptScore W2073451744C71924100 @default.
- W2073451744 hasConceptScore W2073451744C86803240 @default.
- W2073451744 hasLocation W20734517441 @default.
- W2073451744 hasLocation W20734517442 @default.
- W2073451744 hasOpenAccess W2073451744 @default.
- W2073451744 hasPrimaryLocation W20734517441 @default.
- W2073451744 hasRelatedWork W1994068885 @default.
- W2073451744 hasRelatedWork W2051942816 @default.
- W2073451744 hasRelatedWork W2065835785 @default.
- W2073451744 hasRelatedWork W2073451744 @default.
- W2073451744 hasRelatedWork W2131377884 @default.
- W2073451744 hasRelatedWork W2133641226 @default.
- W2073451744 hasRelatedWork W2149724265 @default.
- W2073451744 hasRelatedWork W2167322121 @default.
- W2073451744 hasRelatedWork W2287959475 @default.
- W2073451744 hasRelatedWork W2297131617 @default.
- W2073451744 isParatext "false" @default.
- W2073451744 isRetracted "false" @default.
- W2073451744 magId "2073451744" @default.
- W2073451744 workType "article" @default.