Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073453161> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2073453161 endingPage "502" @default.
- W2073453161 startingPage "496" @default.
- W2073453161 abstract "BACKGROUND: In this study, we sought to compare the long-term safety and efficacy of biphasic insulin aspart 30 (BIAsp30) with that of biphasic human insulin 30 (BHI30) over a period of 24 months in patients with type 2 diabetes. METHODS: Patients with type 2 diabetes (n=125) were assigned to twice-daily BIAsp30 or BHI30 and participated in both a 3-month initial period and a 21-month extension of a randomized, controlled, multinational trial. RESULTS: No significant difference was found in mean HbA(1c) after 24 months [BIAsp30, 8.35+/-0.20%; BHI30 8.13+/-0.16%; adjusted mean difference (BIAsp30-BHI30) 0.03 (90% CI -0.29 to 0.34)%, P=0.89]. The proportion of patients experiencing major hypoglycaemia was also similar during the first year (BIAsp30, 5%; BHI30, 8%; P=0.72), but it was significantly lower with BIAsp30 than with BHI30 during the second year (BIAsp30, 0%; BHI30, 10%; P=0.04). The proportion experiencing minor hypoglycaemia was not significantly different. No significant difference was recorded in changes in nonspecific insulin antibody levels after 24 months (BIAsp30, 4.87+/-1.92%; BHI30; 1.00+/-1.66%; P=0.13). Body weight change was 0.05+/-0.81 kg in the BIAsp30 group and 2.00+/-0.69 kg in the BHI30 group (P=0.07). CONCLUSIONS: Reduced major hypoglycaemia compared with BHI30 during the second year of treatment and comparable HbA(1c) levels after 24 months appear to support the hypothesis that the improved pharmacokinetic profile of BIAsp30 may favourably affect the balance between hypoglycaemia and hyperglycaemia in insulin-treated type 2 diabetes." @default.
- W2073453161 created "2016-06-24" @default.
- W2073453161 creator A5001086144 @default.
- W2073453161 creator A5005155940 @default.
- W2073453161 creator A5034923958 @default.
- W2073453161 creator A5087844534 @default.
- W2073453161 date "2004-12-01" @default.
- W2073453161 modified "2023-10-03" @default.
- W2073453161 title "Long-term efficacy and safety of biphasic insulin aspart in patients with type 2 diabetes" @default.
- W2073453161 cites W1512877138 @default.
- W2073453161 cites W1967655470 @default.
- W2073453161 cites W1989507710 @default.
- W2073453161 cites W2005300371 @default.
- W2073453161 cites W2006998866 @default.
- W2073453161 cites W2042745397 @default.
- W2073453161 cites W2049885152 @default.
- W2073453161 cites W2053398017 @default.
- W2073453161 cites W2058804545 @default.
- W2073453161 cites W2065443996 @default.
- W2073453161 cites W2070818248 @default.
- W2073453161 cites W2084219668 @default.
- W2073453161 cites W2090582239 @default.
- W2073453161 cites W2101930436 @default.
- W2073453161 cites W2104888919 @default.
- W2073453161 cites W2126196596 @default.
- W2073453161 cites W2160252336 @default.
- W2073453161 cites W2786617581 @default.
- W2073453161 cites W4292528167 @default.
- W2073453161 doi "https://doi.org/10.1016/j.ejim.2004.10.001" @default.
- W2073453161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15668084" @default.
- W2073453161 hasPublicationYear "2004" @default.
- W2073453161 type Work @default.
- W2073453161 sameAs 2073453161 @default.
- W2073453161 citedByCount "97" @default.
- W2073453161 countsByYear W20734531612012 @default.
- W2073453161 countsByYear W20734531612013 @default.
- W2073453161 countsByYear W20734531612014 @default.
- W2073453161 countsByYear W20734531612015 @default.
- W2073453161 countsByYear W20734531612016 @default.
- W2073453161 countsByYear W20734531612017 @default.
- W2073453161 countsByYear W20734531612018 @default.
- W2073453161 countsByYear W20734531612019 @default.
- W2073453161 countsByYear W20734531612021 @default.
- W2073453161 crossrefType "journal-article" @default.
- W2073453161 hasAuthorship W2073453161A5001086144 @default.
- W2073453161 hasAuthorship W2073453161A5005155940 @default.
- W2073453161 hasAuthorship W2073453161A5034923958 @default.
- W2073453161 hasAuthorship W2073453161A5087844534 @default.
- W2073453161 hasConcept C126322002 @default.
- W2073453161 hasConcept C134018914 @default.
- W2073453161 hasConcept C168563851 @default.
- W2073453161 hasConcept C197934379 @default.
- W2073453161 hasConcept C2777180221 @default.
- W2073453161 hasConcept C2779306644 @default.
- W2073453161 hasConcept C2779908123 @default.
- W2073453161 hasConcept C2780668416 @default.
- W2073453161 hasConcept C2781232474 @default.
- W2073453161 hasConcept C555293320 @default.
- W2073453161 hasConcept C71924100 @default.
- W2073453161 hasConcept C90924648 @default.
- W2073453161 hasConceptScore W2073453161C126322002 @default.
- W2073453161 hasConceptScore W2073453161C134018914 @default.
- W2073453161 hasConceptScore W2073453161C168563851 @default.
- W2073453161 hasConceptScore W2073453161C197934379 @default.
- W2073453161 hasConceptScore W2073453161C2777180221 @default.
- W2073453161 hasConceptScore W2073453161C2779306644 @default.
- W2073453161 hasConceptScore W2073453161C2779908123 @default.
- W2073453161 hasConceptScore W2073453161C2780668416 @default.
- W2073453161 hasConceptScore W2073453161C2781232474 @default.
- W2073453161 hasConceptScore W2073453161C555293320 @default.
- W2073453161 hasConceptScore W2073453161C71924100 @default.
- W2073453161 hasConceptScore W2073453161C90924648 @default.
- W2073453161 hasIssue "8" @default.
- W2073453161 hasLocation W20734531611 @default.
- W2073453161 hasLocation W20734531612 @default.
- W2073453161 hasOpenAccess W2073453161 @default.
- W2073453161 hasPrimaryLocation W20734531611 @default.
- W2073453161 hasRelatedWork W1972212762 @default.
- W2073453161 hasRelatedWork W2159012137 @default.
- W2073453161 hasRelatedWork W2360370752 @default.
- W2073453161 hasRelatedWork W2383076809 @default.
- W2073453161 hasRelatedWork W2775285435 @default.
- W2073453161 hasRelatedWork W2805857714 @default.
- W2073453161 hasRelatedWork W3032561572 @default.
- W2073453161 hasRelatedWork W3152935002 @default.
- W2073453161 hasRelatedWork W3169596968 @default.
- W2073453161 hasRelatedWork W3197504498 @default.
- W2073453161 hasVolume "15" @default.
- W2073453161 isParatext "false" @default.
- W2073453161 isRetracted "false" @default.
- W2073453161 magId "2073453161" @default.
- W2073453161 workType "article" @default.