FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073453406> ?p ?o ?g. }

• W2073453406 endingPage "2881" @default.
• W2073453406 startingPage "2872" @default.
• W2073453406 abstract "Novel findings that emerged from this study underscore the fact that the dynamic nature of mitochondria leads to functional heterogeneity of [Ca(2+)](mito) with respect to estrogen actions in MCF7 cells. We show that estrogen exposure to cells increased [Ca(2+)](mito) in a high-calcium capacity mitochondrial population but not in low-calcium capacity mitochondria. Physiological concentrations of 17beta-estradiol (E2) modulated Ca(2+)(mito) uptake within 90 s. Interestingly, this calcium response lagged behind the induction of mitochondrial reactive oxygen species (mtROS). The rapid induction of Ca(2+)(mito) in response to E2 and its inhibition by mitochondrial blockers suggest that mitochondria are early nongenomic targets of E2. This suggests that a subpopulation of mitochondria is recruited to respond to new metabolic requirements required by estrogen triggers or, as in this case, E2-induced Ca(2+)(mito) and/or mtROS promotes oxidative signaling without involving nuclear estrogen receptor signaling. Although the early E2-induced Ca(2+) did not alter the expression of genes involved in calcium signaling pathways, an intracellular calcium chelator BAPTA-AM and the Ca(2+)(mito) uniporter blocker ruthenium red prevented E2-induced cell growth. We have shown recently that E2-mediated ROS production controls the promoter activity of cyclin D1 by post-translational modification of calcium sensitive transcription factor CREB. The findings of this study offer a new paradigm that rapid E2-induced changes in mtROS and Ca(2+)(mito) are involved in cell cycle progression presumably through the control of early cell cycle genes. Targeting mitochondria to disrupt communication between mitochondria and ROS/Ca(2+) signaling pathways may provide the basis for a novel anticancer strategy for the treatment of estrogen-dependent breast cancer." @default.
• W2073453406 created "2016-06-24" @default.
• W2073453406 creator A5064565335 @default.
• W2073453406 creator A5066095065 @default.
• W2073453406 creator A5071208511 @default.
• W2073453406 date "2006-02-10" @default.
• W2073453406 modified "2023-10-01" @default.
• W2073453406 title "Estrogen Exerts a Spatial and Temporal Influence on Reactive Oxygen Species Generation that Precedes Calcium Uptake in High-Capacity Mitochondria: Implications for Rapid Nongenomic Signaling of Cell Growth" @default.
• W2073453406 cites W1913671643 @default.
• W2073453406 cites W1971510102 @default.
• W2073453406 cites W2001300582 @default.
• W2073453406 cites W2053182747 @default.
• W2073453406 cites W2062804216 @default.
• W2073453406 cites W2065520371 @default.
• W2073453406 cites W2081064858 @default.
• W2073453406 cites W2086050696 @default.
• W2073453406 cites W2092785520 @default.
• W2073453406 cites W2109689528 @default.
• W2073453406 cites W2115220780 @default.
• W2073453406 cites W2124872060 @default.
• W2073453406 cites W2431841175 @default.
• W2073453406 doi "https://doi.org/10.1021/bi051855x" @default.
• W2073453406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16503642" @default.
• W2073453406 hasPublicationYear "2006" @default.
• W2073453406 type Work @default.
• W2073453406 sameAs 2073453406 @default.
• W2073453406 citedByCount "51" @default.
• W2073453406 countsByYear W20734534062012 @default.
• W2073453406 countsByYear W20734534062013 @default.
• W2073453406 countsByYear W20734534062014 @default.
• W2073453406 countsByYear W20734534062015 @default.
• W2073453406 countsByYear W20734534062016 @default.
• W2073453406 countsByYear W20734534062017 @default.
• W2073453406 countsByYear W20734534062018 @default.
• W2073453406 countsByYear W20734534062019 @default.
• W2073453406 countsByYear W20734534062020 @default.
• W2073453406 countsByYear W20734534062021 @default.
• W2073453406 countsByYear W20734534062022 @default.
• W2073453406 countsByYear W20734534062023 @default.
• W2073453406 crossrefType "journal-article" @default.
• W2073453406 hasAuthorship W2073453406A5064565335 @default.
• W2073453406 hasAuthorship W2073453406A5066095065 @default.
• W2073453406 hasAuthorship W2073453406A5071208511 @default.
• W2073453406 hasConcept C121608353 @default.
• W2073453406 hasConcept C169415338 @default.
• W2073453406 hasConcept C178790620 @default.
• W2073453406 hasConcept C181080969 @default.
• W2073453406 hasConcept C185592680 @default.
• W2073453406 hasConcept C201571599 @default.
• W2073453406 hasConcept C2777229759 @default.
• W2073453406 hasConcept C2778175917 @default.
• W2073453406 hasConcept C2780019300 @default.
• W2073453406 hasConcept C28859421 @default.
• W2073453406 hasConcept C48349386 @default.
• W2073453406 hasConcept C519063684 @default.
• W2073453406 hasConcept C530470458 @default.
• W2073453406 hasConcept C54355233 @default.
• W2073453406 hasConcept C62478195 @default.
• W2073453406 hasConcept C79879829 @default.
• W2073453406 hasConcept C84606932 @default.
• W2073453406 hasConcept C86803240 @default.
• W2073453406 hasConcept C95444343 @default.
• W2073453406 hasConceptScore W2073453406C121608353 @default.
• W2073453406 hasConceptScore W2073453406C169415338 @default.
• W2073453406 hasConceptScore W2073453406C178790620 @default.
• W2073453406 hasConceptScore W2073453406C181080969 @default.
• W2073453406 hasConceptScore W2073453406C185592680 @default.
• W2073453406 hasConceptScore W2073453406C201571599 @default.
• W2073453406 hasConceptScore W2073453406C2777229759 @default.
• W2073453406 hasConceptScore W2073453406C2778175917 @default.
• W2073453406 hasConceptScore W2073453406C2780019300 @default.
• W2073453406 hasConceptScore W2073453406C28859421 @default.
• W2073453406 hasConceptScore W2073453406C48349386 @default.
• W2073453406 hasConceptScore W2073453406C519063684 @default.
• W2073453406 hasConceptScore W2073453406C530470458 @default.
• W2073453406 hasConceptScore W2073453406C54355233 @default.
• W2073453406 hasConceptScore W2073453406C62478195 @default.
• W2073453406 hasConceptScore W2073453406C79879829 @default.
• W2073453406 hasConceptScore W2073453406C84606932 @default.
• W2073453406 hasConceptScore W2073453406C86803240 @default.
• W2073453406 hasConceptScore W2073453406C95444343 @default.
• W2073453406 hasIssue "9" @default.
• W2073453406 hasLocation W20734534061 @default.
• W2073453406 hasLocation W20734534062 @default.
• W2073453406 hasOpenAccess W2073453406 @default.
• W2073453406 hasPrimaryLocation W20734534061 @default.
• W2073453406 hasRelatedWork W1882356554 @default.
• W2073453406 hasRelatedWork W1971639317 @default.
• W2073453406 hasRelatedWork W1980868087 @default.
• W2073453406 hasRelatedWork W1997759034 @default.
• W2073453406 hasRelatedWork W2068316663 @default.
• W2073453406 hasRelatedWork W2115788076 @default.
• W2073453406 hasRelatedWork W2370893403 @default.
• W2073453406 hasRelatedWork W4206141358 @default.
• W2073453406 hasRelatedWork W4295681828 @default.
• W2073453406 hasRelatedWork W881605 @default.
• W2073453406 hasVolume "45" @default.
• W2073453406 isParatext "false" @default.

• next