Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073453630> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2073453630 endingPage "2477" @default.
- W2073453630 startingPage "2474" @default.
- W2073453630 abstract "Human macrophages produce in culture a factor termed mononuclear cell factor (MCF) that increases the production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells. A factor with similar biologic activity is also produced by the murine macrophage cell line P388D1. By using a sequential purification scheme involving ammonium sulfate fractionation; chromatography on DEAE-cellulose, Sephacryl S-200, and phenyl-Sepharose; and discontinuous polyacrylamide gel electrophoresis, the P388D1 cell-derived, synovial cell-stimulating factor was copurified with the lymphocyte-activating factor [LAF; interleukin 1 (IL 1)]. The specific activity of the partially purified LAF (IL 1) was approximately 15,000-fold higher than that of the LAF (IL 1) in the original P388D1 cell culture supernatant. On the basis of (i) the copurification of the P388D1 cell-derived LAF (IL 1) and synovial cell-stimulating factors; (ii) the similarity in cell of origin, molecular weight, and phenylglyoxal sensitivity of human MCF and murine LAF (IL 1); and (iii) the presence of LAF (IL 1) activity in preparations of partially purified human MCF, we have postulated that LAF (IL 1) may have effects on cell targets that are nonlymphoid in nature and also that human MCF may be similar to, or identical with human LAF (IL 1). The results of these studies have raised the possibility that LAF (IL 1) may play a role in macrophage-mediated activation of synovial cells and lymphocytes which are involved in the inflammatory responses associated with rheumatoid arthritis." @default.
- W2073453630 created "2016-06-24" @default.
- W2073453630 creator A5025549901 @default.
- W2073453630 creator A5073777288 @default.
- W2073453630 creator A5085157026 @default.
- W2073453630 creator A5086653323 @default.
- W2073453630 date "1981-04-01" @default.
- W2073453630 modified "2023-10-13" @default.
- W2073453630 title "Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1)." @default.
- W2073453630 cites W1506027486 @default.
- W2073453630 cites W153702717 @default.
- W2073453630 cites W1552392913 @default.
- W2073453630 cites W1566552720 @default.
- W2073453630 cites W1602400123 @default.
- W2073453630 cites W1775749144 @default.
- W2073453630 cites W1965119468 @default.
- W2073453630 cites W1965994467 @default.
- W2073453630 cites W2002050807 @default.
- W2073453630 cites W2003576401 @default.
- W2073453630 cites W2022205459 @default.
- W2073453630 cites W2040951118 @default.
- W2073453630 cites W2051591327 @default.
- W2073453630 cites W2102520206 @default.
- W2073453630 cites W2169601403 @default.
- W2073453630 doi "https://doi.org/10.1073/pnas.78.4.2474" @default.
- W2073453630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/319369" @default.
- W2073453630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6264478" @default.
- W2073453630 hasPublicationYear "1981" @default.
- W2073453630 type Work @default.
- W2073453630 sameAs 2073453630 @default.
- W2073453630 citedByCount "541" @default.
- W2073453630 countsByYear W20734536302012 @default.
- W2073453630 countsByYear W20734536302013 @default.
- W2073453630 countsByYear W20734536302015 @default.
- W2073453630 countsByYear W20734536302017 @default.
- W2073453630 countsByYear W20734536302018 @default.
- W2073453630 countsByYear W20734536302019 @default.
- W2073453630 countsByYear W20734536302020 @default.
- W2073453630 countsByYear W20734536302021 @default.
- W2073453630 countsByYear W20734536302022 @default.
- W2073453630 crossrefType "journal-article" @default.
- W2073453630 hasAuthorship W2073453630A5025549901 @default.
- W2073453630 hasAuthorship W2073453630A5073777288 @default.
- W2073453630 hasAuthorship W2073453630A5085157026 @default.
- W2073453630 hasAuthorship W2073453630A5086653323 @default.
- W2073453630 hasBestOaLocation W20734536301 @default.
- W2073453630 hasConcept C137061746 @default.
- W2073453630 hasConcept C1491633281 @default.
- W2073453630 hasConcept C153911025 @default.
- W2073453630 hasConcept C181199279 @default.
- W2073453630 hasConcept C185592680 @default.
- W2073453630 hasConcept C202751555 @default.
- W2073453630 hasConcept C203014093 @default.
- W2073453630 hasConcept C2777761686 @default.
- W2073453630 hasConcept C2778394429 @default.
- W2073453630 hasConcept C2778690821 @default.
- W2073453630 hasConcept C54355233 @default.
- W2073453630 hasConcept C55493867 @default.
- W2073453630 hasConcept C74172505 @default.
- W2073453630 hasConcept C81885089 @default.
- W2073453630 hasConcept C86803240 @default.
- W2073453630 hasConceptScore W2073453630C137061746 @default.
- W2073453630 hasConceptScore W2073453630C1491633281 @default.
- W2073453630 hasConceptScore W2073453630C153911025 @default.
- W2073453630 hasConceptScore W2073453630C181199279 @default.
- W2073453630 hasConceptScore W2073453630C185592680 @default.
- W2073453630 hasConceptScore W2073453630C202751555 @default.
- W2073453630 hasConceptScore W2073453630C203014093 @default.
- W2073453630 hasConceptScore W2073453630C2777761686 @default.
- W2073453630 hasConceptScore W2073453630C2778394429 @default.
- W2073453630 hasConceptScore W2073453630C2778690821 @default.
- W2073453630 hasConceptScore W2073453630C54355233 @default.
- W2073453630 hasConceptScore W2073453630C55493867 @default.
- W2073453630 hasConceptScore W2073453630C74172505 @default.
- W2073453630 hasConceptScore W2073453630C81885089 @default.
- W2073453630 hasConceptScore W2073453630C86803240 @default.
- W2073453630 hasIssue "4" @default.
- W2073453630 hasLocation W20734536301 @default.
- W2073453630 hasLocation W20734536302 @default.
- W2073453630 hasLocation W20734536303 @default.
- W2073453630 hasLocation W20734536304 @default.
- W2073453630 hasOpenAccess W2073453630 @default.
- W2073453630 hasPrimaryLocation W20734536301 @default.
- W2073453630 hasRelatedWork W2054245410 @default.
- W2073453630 hasRelatedWork W2087976276 @default.
- W2073453630 hasRelatedWork W2092766330 @default.
- W2073453630 hasRelatedWork W2113148377 @default.
- W2073453630 hasRelatedWork W2119122291 @default.
- W2073453630 hasRelatedWork W2162735052 @default.
- W2073453630 hasRelatedWork W2166157026 @default.
- W2073453630 hasRelatedWork W2395235146 @default.
- W2073453630 hasRelatedWork W2778574415 @default.
- W2073453630 hasRelatedWork W9581748 @default.
- W2073453630 hasVolume "78" @default.
- W2073453630 isParatext "false" @default.
- W2073453630 isRetracted "false" @default.
- W2073453630 magId "2073453630" @default.
- W2073453630 workType "article" @default.