FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073454551> ?p ?o ?g. }

• W2073454551 endingPage "980" @default.
• W2073454551 startingPage "970" @default.
• W2073454551 abstract "Summary Pneumococcal pneumonia is a frequent cause of gram-positive sepsis and has a high mortality. The endothelial protein C receptor (EPCR) has been implicated in both the activation of protein C (PC) and the anti-inflammatory actions of activated (A)PC. The aim of this study was to determine the role of the EPCR in murine pneumococcal pneumonia and sepsis. Wild-type (WT), EPCR knockout (KO) and Tie2-EPCR mice, which overexpress EPCR on the endothelium, were infected intranasally (pneumonia) or intravenously (sepsis) with viable Streptococcus pneumoniae and euthanised at 24 or 48 hours after initiation of the infection for analyses. Pneumonia did not alter constitutive EPCR expression on pulmonary endothelium but was associated with an influx of EPCR positive neutrophils into lung tissue. In pneumococcal pneumonia EPCR KO mice demonstrated diminished bacterial growth in the lungs and dissemination to spleen and liver, reduced neutrophil recruitment to the lungs and a mitigated inflammatory response. Moreover, EPCR KO mice displayed enhanced activation of coagulation in the early phase of disease. Correspondingly, in pneumococcal sepsis EPCR KO mice showed reduced bacterial growth in lung and liver and attenuated cytokine release. Conversely, EPCR-overexpressing mice displayed higher bacterial outgrowth in lung, blood, spleen and liver in pneumococcal sepsis. In conclusion, EPCR impairs antibacterial defense in both pneumococcal pneumonia and sepsis, which is associated with an enhanced pro-inflammatory response." @default.
• W2073454551 created "2016-06-24" @default.
• W2073454551 creator A5038678186 @default.
• W2073454551 creator A5042624694 @default.
• W2073454551 creator A5044893401 @default.
• W2073454551 creator A5048965254 @default.
• W2073454551 creator A5056607779 @default.
• W2073454551 creator A5060258124 @default.
• W2073454551 creator A5060943192 @default.
• W2073454551 creator A5087285410 @default.
• W2073454551 creator A5091785748 @default.
• W2073454551 date "2014-01-01" @default.
• W2073454551 modified "2023-10-18" @default.
• W2073454551 title "The endothelial protein C receptor impairs the antibacterial response in murine pneumococcal pneumonia and sepsis" @default.
• W2073454551 cites W172709144 @default.
• W2073454551 cites W1942214469 @default.
• W2073454551 cites W1965306847 @default.
• W2073454551 cites W1982099387 @default.
• W2073454551 cites W1991210310 @default.
• W2073454551 cites W1992217074 @default.
• W2073454551 cites W1994292141 @default.
• W2073454551 cites W1998575929 @default.
• W2073454551 cites W2003748778 @default.
• W2073454551 cites W2012617927 @default.
• W2073454551 cites W2020363094 @default.
• W2073454551 cites W2026944836 @default.
• W2073454551 cites W2027620964 @default.
• W2073454551 cites W2028312175 @default.
• W2073454551 cites W2032227357 @default.
• W2073454551 cites W2042344991 @default.
• W2073454551 cites W2072338377 @default.
• W2073454551 cites W2074866066 @default.
• W2073454551 cites W2075425755 @default.
• W2073454551 cites W2078189088 @default.
• W2073454551 cites W2078539387 @default.
• W2073454551 cites W2105342353 @default.
• W2073454551 cites W2110971703 @default.
• W2073454551 cites W2114289097 @default.
• W2073454551 cites W2118186012 @default.
• W2073454551 cites W2126169052 @default.
• W2073454551 cites W2130141864 @default.
• W2073454551 cites W2133979383 @default.
• W2073454551 cites W2146884753 @default.
• W2073454551 cites W2153090676 @default.
• W2073454551 cites W2167903465 @default.
• W2073454551 doi "https://doi.org/10.1160/th13-10-0859" @default.
• W2073454551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24401906" @default.
• W2073454551 hasPublicationYear "2014" @default.
• W2073454551 type Work @default.
• W2073454551 sameAs 2073454551 @default.
• W2073454551 citedByCount "9" @default.
• W2073454551 countsByYear W20734545512014 @default.
• W2073454551 countsByYear W20734545512015 @default.
• W2073454551 countsByYear W20734545512017 @default.
• W2073454551 countsByYear W20734545512021 @default.
• W2073454551 countsByYear W20734545512023 @default.
• W2073454551 crossrefType "journal-article" @default.
• W2073454551 hasAuthorship W2073454551A5038678186 @default.
• W2073454551 hasAuthorship W2073454551A5042624694 @default.
• W2073454551 hasAuthorship W2073454551A5044893401 @default.
• W2073454551 hasAuthorship W2073454551A5048965254 @default.
• W2073454551 hasAuthorship W2073454551A5056607779 @default.
• W2073454551 hasAuthorship W2073454551A5060258124 @default.
• W2073454551 hasAuthorship W2073454551A5060943192 @default.
• W2073454551 hasAuthorship W2073454551A5087285410 @default.
• W2073454551 hasAuthorship W2073454551A5091785748 @default.
• W2073454551 hasConcept C126322002 @default.
• W2073454551 hasConcept C203014093 @default.
• W2073454551 hasConcept C2776816377 @default.
• W2073454551 hasConcept C2777292125 @default.
• W2073454551 hasConcept C2777714996 @default.
• W2073454551 hasConcept C2777914695 @default.
• W2073454551 hasConcept C2778384902 @default.
• W2073454551 hasConcept C2779892413 @default.
• W2073454551 hasConcept C2780931953 @default.
• W2073454551 hasConcept C2781253189 @default.
• W2073454551 hasConcept C501593827 @default.
• W2073454551 hasConcept C71924100 @default.
• W2073454551 hasConcept C86803240 @default.
• W2073454551 hasConcept C89423630 @default.
• W2073454551 hasConcept C89560881 @default.
• W2073454551 hasConceptScore W2073454551C126322002 @default.
• W2073454551 hasConceptScore W2073454551C203014093 @default.
• W2073454551 hasConceptScore W2073454551C2776816377 @default.
• W2073454551 hasConceptScore W2073454551C2777292125 @default.
• W2073454551 hasConceptScore W2073454551C2777714996 @default.
• W2073454551 hasConceptScore W2073454551C2777914695 @default.
• W2073454551 hasConceptScore W2073454551C2778384902 @default.
• W2073454551 hasConceptScore W2073454551C2779892413 @default.
• W2073454551 hasConceptScore W2073454551C2780931953 @default.
• W2073454551 hasConceptScore W2073454551C2781253189 @default.
• W2073454551 hasConceptScore W2073454551C501593827 @default.
• W2073454551 hasConceptScore W2073454551C71924100 @default.
• W2073454551 hasConceptScore W2073454551C86803240 @default.
• W2073454551 hasConceptScore W2073454551C89423630 @default.
• W2073454551 hasConceptScore W2073454551C89560881 @default.
• W2073454551 hasIssue "05" @default.
• W2073454551 hasLocation W20734545511 @default.

• next