FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073455004> ?p ?o ?g. }

• W2073455004 endingPage "1865" @default.
• W2073455004 startingPage "1857" @default.
• W2073455004 abstract "Polioviruses possess three major antigenic sites which have been located chemically and structurally on the particle. One of these sites, designated site 1, is strongly immunodominant for serotype 3, but highly immunorecessive for type 1. We report that monoclonal antibodies directed against site 1 of type 1 poliovirus may be isolated by an altered route of immunization of the donor mice. Site 1 is shown to be highly variable for type 1, but highly conserved for type 3 poliovirus, although the converse would be predicted from their immunodominance. The evidence presented suggests that the antigenic conservation is associated with a strong selective pressure for a proteolytic cleavage site within site 1 of type 3. As proteolytic cleavage results in the loss of the antigenicity of site 1 the presence of the cleavage site in a virus replicating in the gut in the presence of proteases would protect the virus from neutralizing antibodies directed against uncleaved site 1. The conservation of the site in type 3 is thus consistent with the view that site 1 is a significant target of a human as well as a murine immune response against type 3." @default.
• W2073455004 created "2016-06-24" @default.
• W2073455004 creator A5004014563 @default.
• W2073455004 creator A5036952162 @default.
• W2073455004 creator A5038248074 @default.
• W2073455004 creator A5073269960 @default.
• W2073455004 creator A5081028981 @default.
• W2073455004 creator A5082910023 @default.
• W2073455004 date "1987-07-01" @default.
• W2073455004 modified "2023-10-17" @default.
• W2073455004 title "Conservation in vivo of Protease Cleavage Sites in Antigenic Sites of Poliovirus" @default.
• W2073455004 cites W1583790259 @default.
• W2073455004 cites W1811711839 @default.
• W2073455004 cites W1909528271 @default.
• W2073455004 cites W1972437674 @default.
• W2073455004 cites W1984416131 @default.
• W2073455004 cites W1984776359 @default.
• W2073455004 cites W1988763833 @default.
• W2073455004 cites W1990215145 @default.
• W2073455004 cites W1991624039 @default.
• W2073455004 cites W1993874880 @default.
• W2073455004 cites W2035714742 @default.
• W2073455004 cites W2059165139 @default.
• W2073455004 cites W2060520834 @default.
• W2073455004 cites W2071552617 @default.
• W2073455004 cites W2074161964 @default.
• W2073455004 cites W2161757555 @default.
• W2073455004 cites W2163845414 @default.
• W2073455004 cites W2166195426 @default.
• W2073455004 cites W2169451742 @default.
• W2073455004 doi "https://doi.org/10.1099/0022-1317-68-7-1857" @default.
• W2073455004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3037010" @default.
• W2073455004 hasPublicationYear "1987" @default.
• W2073455004 type Work @default.
• W2073455004 sameAs 2073455004 @default.
• W2073455004 citedByCount "46" @default.
• W2073455004 countsByYear W20734550042014 @default.
• W2073455004 crossrefType "journal-article" @default.
• W2073455004 hasAuthorship W2073455004A5004014563 @default.
• W2073455004 hasAuthorship W2073455004A5036952162 @default.
• W2073455004 hasAuthorship W2073455004A5038248074 @default.
• W2073455004 hasAuthorship W2073455004A5073269960 @default.
• W2073455004 hasAuthorship W2073455004A5081028981 @default.
• W2073455004 hasAuthorship W2073455004A5082910023 @default.
• W2073455004 hasBestOaLocation W20734550041 @default.
• W2073455004 hasConcept C107824862 @default.
• W2073455004 hasConcept C147483822 @default.
• W2073455004 hasConcept C151730666 @default.
• W2073455004 hasConcept C159047783 @default.
• W2073455004 hasConcept C175156509 @default.
• W2073455004 hasConcept C181199279 @default.
• W2073455004 hasConcept C182220744 @default.
• W2073455004 hasConcept C195616568 @default.
• W2073455004 hasConcept C203014093 @default.
• W2073455004 hasConcept C2522874641 @default.
• W2073455004 hasConcept C2776525413 @default.
• W2073455004 hasConcept C2779026604 @default.
• W2073455004 hasConcept C2779631682 @default.
• W2073455004 hasConcept C43369102 @default.
• W2073455004 hasConcept C55493867 @default.
• W2073455004 hasConcept C86803240 @default.
• W2073455004 hasConcept C96267730 @default.
• W2073455004 hasConceptScore W2073455004C107824862 @default.
• W2073455004 hasConceptScore W2073455004C147483822 @default.
• W2073455004 hasConceptScore W2073455004C151730666 @default.
• W2073455004 hasConceptScore W2073455004C159047783 @default.
• W2073455004 hasConceptScore W2073455004C175156509 @default.
• W2073455004 hasConceptScore W2073455004C181199279 @default.
• W2073455004 hasConceptScore W2073455004C182220744 @default.
• W2073455004 hasConceptScore W2073455004C195616568 @default.
• W2073455004 hasConceptScore W2073455004C203014093 @default.
• W2073455004 hasConceptScore W2073455004C2522874641 @default.
• W2073455004 hasConceptScore W2073455004C2776525413 @default.
• W2073455004 hasConceptScore W2073455004C2779026604 @default.
• W2073455004 hasConceptScore W2073455004C2779631682 @default.
• W2073455004 hasConceptScore W2073455004C43369102 @default.
• W2073455004 hasConceptScore W2073455004C55493867 @default.
• W2073455004 hasConceptScore W2073455004C86803240 @default.
• W2073455004 hasConceptScore W2073455004C96267730 @default.
• W2073455004 hasIssue "7" @default.
• W2073455004 hasLocation W20734550041 @default.
• W2073455004 hasLocation W20734550042 @default.
• W2073455004 hasOpenAccess W2073455004 @default.
• W2073455004 hasPrimaryLocation W20734550041 @default.
• W2073455004 hasRelatedWork W1487857142 @default.
• W2073455004 hasRelatedWork W1970146303 @default.
• W2073455004 hasRelatedWork W2059616773 @default.
• W2073455004 hasRelatedWork W2070598222 @default.
• W2073455004 hasRelatedWork W2073455004 @default.
• W2073455004 hasRelatedWork W2077019120 @default.
• W2073455004 hasRelatedWork W2081681357 @default.
• W2073455004 hasRelatedWork W2129272334 @default.
• W2073455004 hasRelatedWork W2133922814 @default.
• W2073455004 hasRelatedWork W2141023231 @default.
• W2073455004 hasVolume "68" @default.
• W2073455004 isParatext "false" @default.
• W2073455004 isRetracted "false" @default.
• W2073455004 magId "2073455004" @default.

• next