Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073455500> ?p ?o ?g. }
- W2073455500 endingPage "408" @default.
- W2073455500 startingPage "397" @default.
- W2073455500 abstract "Thromboxane A2 (TXA2) is a biologically active metabolite of arachidonic acid formed by the action of the terminal synthase, thromboxane A2 synthase (TXA2S), on prostaglandin endoperoxide (PGH2). TXA2 is responsible for multiple biological processes through its cell surface receptor, the T-prostanoid (TP) receptor. Thromboxane A2 synthase and TP are the two necessary components for the functioning of this potent bioactive lipid. Thromboxane A2 is widely implicated in a range of cardiovascular diseases, owing to its acute and chronic effects in promoting platelet aggregation, vasoconstriction, and proliferation. In recent years, additional functional roles for both TXA2S and TP in cancer progression have been indicated. Increased cyclooxygenase (COX)-2 expression has been described in a variety of human cancers, which has focused attention on TXA2 as a downstream metabolite of the COX-2-derived PGH2. Several studies suggest potential involvement of TXA2S and TP in tumor progression, especially tumor cell proliferation, migration, and invasion that are key steps in cancer progression. In addition, the regulation of neovascularization by TP has been identified as a potent source of control during oncogenesis. There have been several recent reviews of TXA2S and TP but thus far none have discussed its role in cancer progression and metastasis in depth. This review will focus on some of the more recent findings and advances with a significant emphasis on understanding the functional role of TXA2S and TP in cancer progression and metastasis." @default.
- W2073455500 created "2016-06-24" @default.
- W2073455500 creator A5007862294 @default.
- W2073455500 creator A5011685966 @default.
- W2073455500 creator A5036962345 @default.
- W2073455500 creator A5044817021 @default.
- W2073455500 creator A5069324598 @default.
- W2073455500 date "2011-10-27" @default.
- W2073455500 modified "2023-10-06" @default.
- W2073455500 title "The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis" @default.
- W2073455500 cites W1514194392 @default.
- W2073455500 cites W1536906814 @default.
- W2073455500 cites W1585808802 @default.
- W2073455500 cites W174668522 @default.
- W2073455500 cites W1802267091 @default.
- W2073455500 cites W1868957569 @default.
- W2073455500 cites W1963980776 @default.
- W2073455500 cites W1964308104 @default.
- W2073455500 cites W1965787764 @default.
- W2073455500 cites W1965789168 @default.
- W2073455500 cites W1970347335 @default.
- W2073455500 cites W1972136525 @default.
- W2073455500 cites W1974263628 @default.
- W2073455500 cites W1975258609 @default.
- W2073455500 cites W1976739913 @default.
- W2073455500 cites W1981581994 @default.
- W2073455500 cites W1985186831 @default.
- W2073455500 cites W1990423568 @default.
- W2073455500 cites W1990752021 @default.
- W2073455500 cites W1992094718 @default.
- W2073455500 cites W1992634781 @default.
- W2073455500 cites W1993389065 @default.
- W2073455500 cites W1996395459 @default.
- W2073455500 cites W1996794995 @default.
- W2073455500 cites W2004067421 @default.
- W2073455500 cites W2011627638 @default.
- W2073455500 cites W2011841402 @default.
- W2073455500 cites W2012237872 @default.
- W2073455500 cites W2013412399 @default.
- W2073455500 cites W2013551103 @default.
- W2073455500 cites W2014046848 @default.
- W2073455500 cites W2015335780 @default.
- W2073455500 cites W2016125182 @default.
- W2073455500 cites W2024015648 @default.
- W2073455500 cites W2024087814 @default.
- W2073455500 cites W2030087792 @default.
- W2073455500 cites W2032870564 @default.
- W2073455500 cites W2034269086 @default.
- W2073455500 cites W2037185437 @default.
- W2073455500 cites W2038472226 @default.
- W2073455500 cites W2039138706 @default.
- W2073455500 cites W2042807925 @default.
- W2073455500 cites W2044378325 @default.
- W2073455500 cites W2047854358 @default.
- W2073455500 cites W2048009051 @default.
- W2073455500 cites W2048958198 @default.
- W2073455500 cites W2050718108 @default.
- W2073455500 cites W2051338926 @default.
- W2073455500 cites W2052263812 @default.
- W2073455500 cites W2055748078 @default.
- W2073455500 cites W2056386014 @default.
- W2073455500 cites W2056913859 @default.
- W2073455500 cites W2060522994 @default.
- W2073455500 cites W2061260675 @default.
- W2073455500 cites W2067224742 @default.
- W2073455500 cites W2067290049 @default.
- W2073455500 cites W2070291618 @default.
- W2073455500 cites W2075969922 @default.
- W2073455500 cites W2078975633 @default.
- W2073455500 cites W2084139367 @default.
- W2073455500 cites W2085029013 @default.
- W2073455500 cites W2086176357 @default.
- W2073455500 cites W2088333712 @default.
- W2073455500 cites W2092198750 @default.
- W2073455500 cites W2092296830 @default.
- W2073455500 cites W2095117268 @default.
- W2073455500 cites W2096287682 @default.
- W2073455500 cites W2097474668 @default.
- W2073455500 cites W2097997344 @default.
- W2073455500 cites W2105100844 @default.
- W2073455500 cites W2105524188 @default.
- W2073455500 cites W2110420148 @default.
- W2073455500 cites W2114769436 @default.
- W2073455500 cites W2118450502 @default.
- W2073455500 cites W2119419445 @default.
- W2073455500 cites W2125232878 @default.
- W2073455500 cites W2126563759 @default.
- W2073455500 cites W2129321695 @default.
- W2073455500 cites W2129502181 @default.
- W2073455500 cites W2132000514 @default.
- W2073455500 cites W2138784927 @default.
- W2073455500 cites W2141355057 @default.
- W2073455500 cites W2142310801 @default.
- W2073455500 cites W2146394216 @default.
- W2073455500 cites W2150241787 @default.
- W2073455500 cites W2152021373 @default.
- W2073455500 cites W2156496801 @default.
- W2073455500 cites W2168914852 @default.