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• W2073477981 endingPage "444" @default.
• W2073477981 startingPage "435" @default.
• W2073477981 abstract "Previous research from our laboratory has implicated the basolateral amygdala (BLA) complex in the acquisition and consolidation of cue-cocaine associations, as well as extinction learning, which may regulate the long-lasting control of conditioned stimuli (CS) over drug-seeking behavior. Given the well established role of NMDA glutamate receptor activation in other forms of amygdalar-based learning, we predicted that BLA-mediated drug-cue associative learning would be NMDA receptor dependent. To test this hypothesis, male Sprague-Dawley rats self-administered i.v. cocaine (0.6 mg/kg/infusion) in the absence of explicit CS pairings (2-h sessions, 5 days), followed by a single 1-h classical conditioning (CC) session, during which they received passive infusions of cocaine discretely paired with a light+tone stimulus complex. Following additional cocaine self-administration sessions in the absence of the CS (2-h sessions, 5 days) and extinction training sessions (no cocaine or CS presentation, 2-h sessions, 7 days), the ability of the CS to reinstate cocaine-seeking on three test days was assessed. Rats received bilateral intra-BLA infusions (0.5 microl/hemisphere) of vehicle or the selective NMDA receptor antagonist, 2-amino-5-phosphonovalerate (AP-5), immediately prior to the CC session (acquisition), immediately following the CC session (consolidation), or immediately following reinstatement testing (consolidation of conditioned-cued extinction learning). AP-5 administered before or after CC attenuated subsequent CS-induced reinstatement, whereas AP-5 administered immediately following the first two reinstatement tests impaired the extinction of cocaine-seeking behavior. These results suggest that NMDA receptor-mediated mechanisms within the BLA play a crucial role in the consolidation of drug-CS associations into long-term memories that, in turn, drive cocaine-seeking during relapse." @default.
• W2073477981 created "2016-06-24" @default.
• W2073477981 creator A5044997656 @default.
• W2073477981 creator A5085809718 @default.
• W2073477981 date "2007-11-01" @default.
• W2073477981 modified "2023-09-23" @default.
• W2073477981 title "NMDA receptor blockade in the basolateral amygdala disrupts consolidation of stimulus-reward memory and extinction learning during reinstatement of cocaine-seeking in an animal model of relapse" @default.
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• W2073477981 doi "https://doi.org/10.1016/j.nlm.2007.05.006" @default.
• W2073477981 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2080837" @default.
• W2073477981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17613253" @default.
• W2073477981 hasPublicationYear "2007" @default.
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