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- W2073485379 abstract "Abstract Adrenalin in oily or watery solution, alone and in combination with thyroid extract, was administered to thyroidectomized and intact rabbits over varying periods of time. It was not possible to produce more than slight cardiac hypertrophy and myocardial degeneration with adrenalin, but the synergism between thyroid and adrenalin resulted in much more marked cardiac hypertrophy, myocardial fibrosis, and infiltrative lesions. Thyroidectomy appeared to sensitize the animals to the effects of thyroid extract. Cardiac hypertrophy and myocardial damage were more marked in the thyroidectomized than in the intact animals which received thyroid, or thyroid and adrenalin. Treatment with an aqueous solution of adrenalin and thyroid resulted in much more marked effects on the heart than the slower, more prolonged, oily adrenalin solution and thyroid extract. Cardiac hypertrophy is contingent, not so much on a prolonged, as on an intense, effect of thyroid extract which is associated not only with a failure to gain, but is accompanied by a loss of about 25 per cent or more of the original body weight. When cardiac hypertrophy develops, there is an early rise in the heart weight/body weight ratio. Whether there was, as Stewart thought, an initial rise in heart weight caused by fluid retention, followed by an increase in muscle mass, is not possible to state. In our animals which were allowed after three or four weeks of treatment to maintain, rather than forced to lose, weight, there was a fall of the heart to body weight ratio. We believe that the fall in ratio after an initial rise was not necessarily caused by edema of the heart followed by an increase in the muscle mass. The fall may have been due to the fact that the thyroid effect was not intense enough to stimulate the development of cardiac hypertrophy. A tolerance is quickly developed to thyroid extract in fairly large doses, and, when the effects of the drug have disappeared, they can be restored, as desired, by increasing the dose. The clinical course of, and necropsy observations on, three rabbits with cabbage goiter, which developed fatal hyperthyroidism after small doses of iodine, are discussed. Although hemithyroidectomy was performed in two instances, and iodine was stopped in all three cases, the alteration from hypothyroidism to hyperthyroidism was rapidly fatal in all." @default.
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- W2073485379 date "1944-02-01" @default.
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- W2073485379 title "The effect of thyroid extract, adrenalin, and a combination of these on the hearts of intact and thyroidectomized rabbits" @default.
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- W2073485379 doi "https://doi.org/10.1016/s0002-8703(44)90724-6" @default.
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