Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073488093> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2073488093 endingPage "654" @default.
- W2073488093 startingPage "650" @default.
- W2073488093 abstract "In order to examine the question of whether thyroxine-binding globulin (TBG) influences significantly the peripheral metabolism of 3,3',5-triiodo-L-thyronine (T(3)) in vivo, paired studies of the effects of a large intravenous load of L-thyroxine (T(4)) on the kinetics of (131)I-labeled T(3) metabolism were carried out in five normal subjects. After the T(4) load, both the early distributive loss of labeled T(3) from serum and the volume of T(3) distribution, observed after distribution equilibrium had been attained, were greatly increased. These alterations were consistent with those to be expected from displacement of T(3) from its extracellular binding sites. After the T(4) load, however, the fractional rate of T(3) turnover was decreased. This finding is ascribed either to competition between T(3) and T(4) for common intracellular pathways of degradation or excretion or to displacement of T(3) from sites of more rapid to sites of less rapid metabolism. These effects of alterations in the binding activity of TBG on the peripheral metabolism of T(3), together with those previously reported by others, are consistent with the interpretation that T(3) is significantly bound by TBG in vivo. However, it is suggested that the effects of alterations in the T(3)-TBG binding interaction on the metabolism of T(3) are obscured by alterations in the extracellular-cellular partitioning of T(4) that would result from concurrent alterations in T(4)-binding by TBG." @default.
- W2073488093 created "2016-06-24" @default.
- W2073488093 creator A5019736472 @default.
- W2073488093 creator A5024930461 @default.
- W2073488093 creator A5091065594 @default.
- W2073488093 date "1970-04-01" @default.
- W2073488093 modified "2023-10-13" @default.
- W2073488093 title "The effects of an acute load of thyroxine on the transport and peripheral metabolism of triiodothyronine in man" @default.
- W2073488093 cites W1975261266 @default.
- W2073488093 cites W1987657635 @default.
- W2073488093 cites W1995032904 @default.
- W2073488093 cites W1997529433 @default.
- W2073488093 cites W2033432519 @default.
- W2073488093 cites W2035678226 @default.
- W2073488093 cites W2041160265 @default.
- W2073488093 cites W2043231556 @default.
- W2073488093 cites W2051454058 @default.
- W2073488093 cites W2072920961 @default.
- W2073488093 cites W2099037453 @default.
- W2073488093 cites W2100286098 @default.
- W2073488093 cites W2443032083 @default.
- W2073488093 doi "https://doi.org/10.1172/jci106276" @default.
- W2073488093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/322519" @default.
- W2073488093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4986213" @default.
- W2073488093 hasPublicationYear "1970" @default.
- W2073488093 type Work @default.
- W2073488093 sameAs 2073488093 @default.
- W2073488093 citedByCount "30" @default.
- W2073488093 crossrefType "journal-article" @default.
- W2073488093 hasAuthorship W2073488093A5019736472 @default.
- W2073488093 hasAuthorship W2073488093A5024930461 @default.
- W2073488093 hasAuthorship W2073488093A5091065594 @default.
- W2073488093 hasBestOaLocation W20734880931 @default.
- W2073488093 hasConcept C126322002 @default.
- W2073488093 hasConcept C134018914 @default.
- W2073488093 hasConcept C150903083 @default.
- W2073488093 hasConcept C185592680 @default.
- W2073488093 hasConcept C207001950 @default.
- W2073488093 hasConcept C2777239931 @default.
- W2073488093 hasConcept C2778288131 @default.
- W2073488093 hasConcept C2779074563 @default.
- W2073488093 hasConcept C28406088 @default.
- W2073488093 hasConcept C526584372 @default.
- W2073488093 hasConcept C55493867 @default.
- W2073488093 hasConcept C62231903 @default.
- W2073488093 hasConcept C71924100 @default.
- W2073488093 hasConcept C79879829 @default.
- W2073488093 hasConcept C86803240 @default.
- W2073488093 hasConceptScore W2073488093C126322002 @default.
- W2073488093 hasConceptScore W2073488093C134018914 @default.
- W2073488093 hasConceptScore W2073488093C150903083 @default.
- W2073488093 hasConceptScore W2073488093C185592680 @default.
- W2073488093 hasConceptScore W2073488093C207001950 @default.
- W2073488093 hasConceptScore W2073488093C2777239931 @default.
- W2073488093 hasConceptScore W2073488093C2778288131 @default.
- W2073488093 hasConceptScore W2073488093C2779074563 @default.
- W2073488093 hasConceptScore W2073488093C28406088 @default.
- W2073488093 hasConceptScore W2073488093C526584372 @default.
- W2073488093 hasConceptScore W2073488093C55493867 @default.
- W2073488093 hasConceptScore W2073488093C62231903 @default.
- W2073488093 hasConceptScore W2073488093C71924100 @default.
- W2073488093 hasConceptScore W2073488093C79879829 @default.
- W2073488093 hasConceptScore W2073488093C86803240 @default.
- W2073488093 hasIssue "4" @default.
- W2073488093 hasLocation W20734880931 @default.
- W2073488093 hasLocation W20734880932 @default.
- W2073488093 hasLocation W20734880933 @default.
- W2073488093 hasLocation W20734880934 @default.
- W2073488093 hasOpenAccess W2073488093 @default.
- W2073488093 hasPrimaryLocation W20734880931 @default.
- W2073488093 hasRelatedWork W1983274469 @default.
- W2073488093 hasRelatedWork W2041345005 @default.
- W2073488093 hasRelatedWork W2066485846 @default.
- W2073488093 hasRelatedWork W2070295037 @default.
- W2073488093 hasRelatedWork W2070480234 @default.
- W2073488093 hasRelatedWork W2080164112 @default.
- W2073488093 hasRelatedWork W2123776185 @default.
- W2073488093 hasRelatedWork W2133230490 @default.
- W2073488093 hasRelatedWork W2156615339 @default.
- W2073488093 hasRelatedWork W2413042786 @default.
- W2073488093 hasVolume "49" @default.
- W2073488093 isParatext "false" @default.
- W2073488093 isRetracted "false" @default.
- W2073488093 magId "2073488093" @default.
- W2073488093 workType "article" @default.