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- W2073498982 abstract "Pegylated liposomal doxorubicin (PLD) is a liposomal formulation with a distinct pharmacokinetic profile characterized by an extended circulation time and a reduced volume of distribution. Biodistribution animal studies indicate preferential accumulation of PLD into various implanted mouse-human tumors, with an enhancement of liposomal drug tumor levels compared with free drugs. The extended circulation time of pegylated liposomes and their ability to extravasate through the leaky vasculature of tumors results in the enhanced delivery of liposomal drug and/or radiotracers to the tumor site in patients with cancer. In malignant effusions, Kaposi sarcoma skin lesions, and a variety of solid tumors there is evidence of selective tumor uptake detected by various methods. Pegylated liposomal doxorubicin has been approved for clinical use in a variety of neoplastic conditions because of its antitumor efficacy and unique safety profile with an impressive reduction of cardiac toxicity in comparison with conventional doxorubicin." @default.
- W2073498982 created "2016-06-24" @default.
- W2073498982 creator A5050652180 @default.
- W2073498982 creator A5060158935 @default.
- W2073498982 date "2008-02-01" @default.
- W2073498982 modified "2023-09-27" @default.
- W2073498982 title "Clinical Pharmacology of Liposomal Anthracyclines: Focus on Pegylated Liposomal Doxorubicin" @default.
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- W2073498982 doi "https://doi.org/10.3816/clm.2008.n.001" @default.
- W2073498982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18501085" @default.
- W2073498982 hasPublicationYear "2008" @default.
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