FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073506564> ?p ?o ?g. }

• W2073506564 endingPage "400" @default.
• W2073506564 startingPage "385" @default.
• W2073506564 abstract "1. Membrane potential responses to ionophoretically applied noradrenaline and to field stimulation were studied in the mouse anococcygeus muscle using intracellular recording techniques.2. The ionophoretic application of noradrenaline produced charge-dependent depolarizations whose total duration was 1-2 s at room temperature and which were characterized by a delay between the start of the ionophoretic pulse and the onset of depolarization (termed the latency of the responses). On occasion ionophoresis of noradrenaline did not depolarize the muscle even though it seemed that successful ejection of noradrenaline had occurred as small localized contractions could be seen.3. The characteristics of these depolarizations were unaffected by tetrodotoxin (10(-7) M) and could not be reproduced when the ionophoretic pipette contained 2 M-NaCl rather than noradrenaline. Moreover noradrenaline still produced depolarizations in denervated muscle and thus it is concluded that the responses were caused by noradrenaline released from the ionophoretic micropipette and not from the intrinsic noradrenergic nerves.4. Field stimulation of innervated muscle usually evoked excitatory junction potentials (e.j.p.s), but sometimes inhibitory junction potentials (i.j.p.s) or a mixture of e.j.p.s and i.j.p.s were observed. The time course of the e.j.p.s was slightly longer than that of the ionophoretic depolarizations which was accounted for by a smaller latency of the ionophoretically induced responses.5. The pharmacology of the nerve-evoked e.j.p.s and the ionophoretically induced depolarizations was similar as both types of responses were antagonized by alpha(1)-adrenoceptor blocking agents (phentolamine and prazosin) but were unaffected by the beta-adrenoceptor antagonist, propranolol. It is probable that noradrenaline released from the intrinsic nerves and that from the ionophoretic micropipette were acting on the same adrenoceptors.6. The latency and to a lesser extent the rise-time of the depolarizations produced by the ionophoretic application of noradrenaline was highly sensitive to changes in temperature of the bathing fluid (Q(10)s > 2) whereas the half-decay time was relatively insensitive to temperature changes (Q(10) approximately 1.5). In addition the latency of the depolarizations was not altered by inhibiting the noradrenaline-uptake mechanism with cocaine (2 x 10(-6) M) or by alpha-adrenoceptor blocking agents. Thus it seems likely that the latency of the responses is a property of the noradrenaline-receptor interaction rather than being caused by other phenomena such as diffusion of noradrenaline." @default.
• W2073506564 created "2016-06-24" @default.
• W2073506564 creator A5066764552 @default.
• W2073506564 date "1982-05-01" @default.
• W2073506564 modified "2023-09-25" @default.
• W2073506564 title "Membrane potential responses of the mouse anococcygeus muscle to ionophoretically applied noradrenaline" @default.
• W2073506564 cites W1970100311 @default.
• W2073506564 cites W1985157597 @default.
• W2073506564 cites W1991052647 @default.
• W2073506564 cites W1995197959 @default.
• W2073506564 cites W1997727342 @default.
• W2073506564 cites W2014111373 @default.
• W2073506564 cites W2024120181 @default.
• W2073506564 cites W2025810970 @default.
• W2073506564 cites W2036080198 @default.
• W2073506564 cites W2061057525 @default.
• W2073506564 cites W2089508914 @default.
• W2073506564 cites W2111687530 @default.
• W2073506564 cites W2299446373 @default.
• W2073506564 doi "https://doi.org/10.1113/jphysiol.1982.sp014200" @default.
• W2073506564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1251482" @default.
• W2073506564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7108802" @default.
• W2073506564 hasPublicationYear "1982" @default.
• W2073506564 type Work @default.
• W2073506564 sameAs 2073506564 @default.
• W2073506564 citedByCount "18" @default.
• W2073506564 crossrefType "journal-article" @default.
• W2073506564 hasAuthorship W2073506564A5066764552 @default.
• W2073506564 hasBestOaLocation W20735065641 @default.
• W2073506564 hasConcept C112592302 @default.
• W2073506564 hasConcept C12554922 @default.
• W2073506564 hasConcept C147789679 @default.
• W2073506564 hasConcept C151552171 @default.
• W2073506564 hasConcept C169760540 @default.
• W2073506564 hasConcept C17077164 @default.
• W2073506564 hasConcept C181911157 @default.
• W2073506564 hasConcept C185263204 @default.
• W2073506564 hasConcept C185592680 @default.
• W2073506564 hasConcept C24998067 @default.
• W2073506564 hasConcept C2776741303 @default.
• W2073506564 hasConcept C4141045 @default.
• W2073506564 hasConcept C55493867 @default.
• W2073506564 hasConcept C86803240 @default.
• W2073506564 hasConceptScore W2073506564C112592302 @default.
• W2073506564 hasConceptScore W2073506564C12554922 @default.
• W2073506564 hasConceptScore W2073506564C147789679 @default.
• W2073506564 hasConceptScore W2073506564C151552171 @default.
• W2073506564 hasConceptScore W2073506564C169760540 @default.
• W2073506564 hasConceptScore W2073506564C17077164 @default.
• W2073506564 hasConceptScore W2073506564C181911157 @default.
• W2073506564 hasConceptScore W2073506564C185263204 @default.
• W2073506564 hasConceptScore W2073506564C185592680 @default.
• W2073506564 hasConceptScore W2073506564C24998067 @default.
• W2073506564 hasConceptScore W2073506564C2776741303 @default.
• W2073506564 hasConceptScore W2073506564C4141045 @default.
• W2073506564 hasConceptScore W2073506564C55493867 @default.
• W2073506564 hasConceptScore W2073506564C86803240 @default.
• W2073506564 hasIssue "1" @default.
• W2073506564 hasLocation W20735065641 @default.
• W2073506564 hasLocation W20735065642 @default.
• W2073506564 hasLocation W20735065643 @default.
• W2073506564 hasOpenAccess W2073506564 @default.
• W2073506564 hasPrimaryLocation W20735065641 @default.
• W2073506564 hasRelatedWork W1582488751 @default.
• W2073506564 hasRelatedWork W1877020112 @default.
• W2073506564 hasRelatedWork W1994338191 @default.
• W2073506564 hasRelatedWork W2002890721 @default.
• W2073506564 hasRelatedWork W2033964038 @default.
• W2073506564 hasRelatedWork W2039504750 @default.
• W2073506564 hasRelatedWork W2070007440 @default.
• W2073506564 hasRelatedWork W2077087457 @default.
• W2073506564 hasRelatedWork W2409063331 @default.
• W2073506564 hasRelatedWork W279338557 @default.
• W2073506564 hasVolume "326" @default.
• W2073506564 isParatext "false" @default.
• W2073506564 isRetracted "false" @default.
• W2073506564 magId "2073506564" @default.
• W2073506564 workType "article" @default.