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- W2073507989 endingPage "1101" @default.
- W2073507989 startingPage "1085" @default.
- W2073507989 abstract "Antibacterial drug discovery has undertaken a major experiment in the 12 years since the first bacterial genomes were sequenced. Genome mining has identified hundreds of potential targets that have been distilled to a relatively small number of broad-spectrum targets (‘low-hanging fruit’) using the genetics tools of modern microbiology. Prosecuting these targets with high-throughput screens has led to a disappointingly small number of lead series that have mostly evaporated under closer scrutiny. In the meantime, multi-drug resistant pathogens are becoming a serious challenge in the clinic and the community and the number of pharmaceutical firms pursuing antibacterial discovery has declined. Filling the antibacterial development pipeline with novel chemical series is a significant challenge that will require the collaboration of scientists from many disciplines. Fortunately, advancements in the tools of structural biology and of in silico modeling are opening up new avenues of research that may help deal with the problems associated with discovering novel antibiotics." @default.
- W2073507989 created "2016-06-24" @default.
- W2073507989 creator A5001909611 @default.
- W2073507989 creator A5007281151 @default.
- W2073507989 creator A5039616022 @default.
- W2073507989 date "2007-08-01" @default.
- W2073507989 modified "2023-10-03" @default.
- W2073507989 title "Structural biology approaches to antibacterial drug discovery" @default.
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