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- W2073510062 abstract "We have isolated a cDNA from Dirofilaria immitis that encodes a predicted ion channel subunit, Di-LGR-1. Secondary structure predictions and database searches reveal that Di-LGR-1 is distantly related to ligand-gated anion channels, such as the GABA(A) receptors, though there are marked differences in the sequences of the putative channel forming regions. Di-LGR-1 has 52% sequence identity to the Caenorhabditis elegans predicted polypeptide, T27A1.4: neighbour-joining trees show that these two polypeptides are the most divergent members of the nematode ligand-gated anion channel family. No close homologues are present in vertebrates, suggesting that their function may be specific to nematodes. RNAi experiments using a fragment of T27A1.4 with C. elegans failed to reveal any obvious phenotype, so the function of these channels remains unknown." @default.
- W2073510062 created "2016-06-24" @default.
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- W2073510062 date "2004-11-01" @default.
- W2073510062 modified "2023-09-25" @default.
- W2073510062 title "Dirofilaria immitis: identification of a novel ligand-gated ion channel-related polypeptide" @default.
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- W2073510062 doi "https://doi.org/10.1016/j.exppara.2004.08.003" @default.
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