FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073511080> ?p ?o ?g. }

• W2073511080 endingPage "274" @default.
• W2073511080 startingPage "259" @default.
• W2073511080 abstract "Mechanical loads can profoundly alter cell growth and cell proliferation. The dinoflagellates are especially sensitive to mechanical stimulation. Many species will be arrested in cell cycle in response to turbulence or shear stress. We demonstrate here that mechanical shaking and caffeine, the ryanodine-receptor agonist, induced an elevation of cytosolic calcium in the dinoflagellate Crypthecodinium cohnii. Dantrolene, a ryanodine-receptor antagonist, dose-dependently inhibited both shaking-induced and caffeine-induced calcium release. Similar to the effect of mechanical shaking, caffeine alone dose-dependently and reversibly induced cell cycle arrest in dinoflagellates. Prolonged shaking substantially abolished the magnitude of caffeine-induced calcium release and vice-versa, suggesting that both agents released calcium from similar stores through ryanodine receptors. Fluorescence-conjugated ryanodine gave positive labeling, which could be blocked by ryanodine, in the cortice of C. cohnii cells. In addition, caffeine or shaking mobilized intracellular chlortetracycline (CTC)-positive membrane-bound calcium, which could be similarly depleted by t-BuBHQ, a SERCA pump inhibitor. Prior treatment with shaking or caffeine also inhibited the ability of the other agent in mobilizing CTC-positive calcium. CTC-positive microsomal fractions could also be induced to release calcium by caffeine and cADPR, the ryanodinee receptor modulator. t-BuBHQ, but not calcium ionophores, induced cell cycle arrest, and the calcium chelator BAPTA-AM was unable to rescue caffeine-induced cell cycle arrest. These data culminate to suggest that mobilization or depletion of caffeine-sensitive calcium stores, but not calcium elevation per se, is involved in the induction of cell cycle arrest by mechanical stimulation. The present study establishes the role of caffeine-sensitive calcium stores in the regulation of cell cycle progression." @default.
• W2073511080 created "2016-06-24" @default.
• W2073511080 creator A5020813212 @default.
• W2073511080 creator A5030515044 @default.
• W2073511080 creator A5040282477 @default.
• W2073511080 creator A5070721491 @default.
• W2073511080 creator A5074242872 @default.
• W2073511080 date "2006-03-01" @default.
• W2073511080 modified "2023-09-30" @default.
• W2073511080 title "Involvement of calcium mobilization from caffeine-sensitive stores in mechanically induced cell cycle arrest in the dinoflagellate Crypthecodinium cohnii" @default.
• W2073511080 cites W1168882120 @default.
• W2073511080 cites W1525045344 @default.
• W2073511080 cites W1541024168 @default.
• W2073511080 cites W1543140157 @default.
• W2073511080 cites W1548027699 @default.
• W2073511080 cites W1602784471 @default.
• W2073511080 cites W1736687470 @default.
• W2073511080 cites W1825217901 @default.
• W2073511080 cites W1825270425 @default.
• W2073511080 cites W1908983746 @default.
• W2073511080 cites W1909657903 @default.
• W2073511080 cites W1958159270 @default.
• W2073511080 cites W1967710441 @default.
• W2073511080 cites W1972484086 @default.
• W2073511080 cites W1974360309 @default.
• W2073511080 cites W1975174812 @default.
• W2073511080 cites W1976641875 @default.
• W2073511080 cites W1980001067 @default.
• W2073511080 cites W1986542876 @default.
• W2073511080 cites W1986615127 @default.
• W2073511080 cites W1991339054 @default.
• W2073511080 cites W1995519760 @default.
• W2073511080 cites W1997018082 @default.
• W2073511080 cites W1998788792 @default.
• W2073511080 cites W2000561894 @default.
• W2073511080 cites W2001560120 @default.
• W2073511080 cites W2002117344 @default.
• W2073511080 cites W2002361405 @default.
• W2073511080 cites W2002696717 @default.
• W2073511080 cites W2010287131 @default.
• W2073511080 cites W2025443689 @default.
• W2073511080 cites W2035143633 @default.
• W2073511080 cites W2035578875 @default.
• W2073511080 cites W2044884232 @default.
• W2073511080 cites W2054015257 @default.
• W2073511080 cites W2056657415 @default.
• W2073511080 cites W2056736169 @default.
• W2073511080 cites W2057687087 @default.
• W2073511080 cites W2062963197 @default.
• W2073511080 cites W2065227922 @default.
• W2073511080 cites W2072240092 @default.
• W2073511080 cites W2074307831 @default.
• W2073511080 cites W2077210641 @default.
• W2073511080 cites W2080079953 @default.
• W2073511080 cites W2081933470 @default.
• W2073511080 cites W2083049504 @default.
• W2073511080 cites W2084477895 @default.
• W2073511080 cites W2088602091 @default.
• W2073511080 cites W2094701675 @default.
• W2073511080 cites W2094757640 @default.
• W2073511080 cites W2095246856 @default.
• W2073511080 cites W2098994734 @default.
• W2073511080 cites W2103241004 @default.
• W2073511080 cites W2105207308 @default.
• W2073511080 cites W2110841019 @default.
• W2073511080 cites W2114685509 @default.
• W2073511080 cites W2119278977 @default.
• W2073511080 cites W2121230421 @default.
• W2073511080 cites W2127020680 @default.
• W2073511080 cites W2130151244 @default.
• W2073511080 cites W2139739847 @default.
• W2073511080 cites W2146239090 @default.
• W2073511080 cites W2154732508 @default.
• W2073511080 cites W2155079019 @default.
• W2073511080 cites W2169280826 @default.
• W2073511080 cites W2171501631 @default.
• W2073511080 cites W2175550489 @default.
• W2073511080 cites W2317582623 @default.
• W2073511080 cites W2322217870 @default.
• W2073511080 cites W2402680344 @default.
• W2073511080 cites W2403160221 @default.
• W2073511080 cites W2407918020 @default.
• W2073511080 doi "https://doi.org/10.1016/j.ceca.2005.11.001" @default.
• W2073511080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16364435" @default.
• W2073511080 hasPublicationYear "2006" @default.
• W2073511080 type Work @default.
• W2073511080 sameAs 2073511080 @default.
• W2073511080 citedByCount "20" @default.
• W2073511080 countsByYear W20735110802012 @default.
• W2073511080 countsByYear W20735110802013 @default.
• W2073511080 countsByYear W20735110802019 @default.
• W2073511080 countsByYear W20735110802020 @default.
• W2073511080 countsByYear W20735110802021 @default.
• W2073511080 countsByYear W20735110802022 @default.
• W2073511080 countsByYear W20735110802023 @default.
• W2073511080 crossrefType "journal-article" @default.
• W2073511080 hasAuthorship W2073511080A5020813212 @default.
• W2073511080 hasAuthorship W2073511080A5030515044 @default.

• next