FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073511211> ?p ?o ?g. }

• W2073511211 endingPage "e1004006" @default.
• W2073511211 startingPage "e1004006" @default.
• W2073511211 abstract "The human β2-adrenergic receptor (β2AR), a member of the G-protein coupled receptor (GPCR) family, is expressed in bronchial smooth muscle cells. Upon activation by agonists, β2AR causes bronchodilation and relief in asthma patients. The N-terminal polymorphism of β2AR at the 16th position, Arg16Gly, has warranted a lot of attention since it is linked to variations in response to albuterol (agonist) treatment. Although the β2AR is one of the well-studied GPCRs, the N-terminus which harbors this mutation, is absent in all available experimental structures. The goal of this work was to study the molecular level differences between the N-terminal variants using structural modeling and atomistic molecular dynamics simulations. Our simulations reveal that the N-terminal region of the Arg variant shows greater dynamics than the Gly variant, leading to differential placement. Further, the position and dynamics of the N-terminal region, further, affects the ligand binding-site accessibility. Interestingly, long-range effects are also seen at the ligand binding site, which is marginally larger in the Gly as compared to the Arg variant resulting in the preferential docking of albuterol to the Gly variant. This study thus reveals key differences between the variants providing a molecular framework towards understanding the variable drug response in asthma patients." @default.
• W2073511211 created "2016-06-24" @default.
• W2073511211 creator A5024022206 @default.
• W2073511211 creator A5040581077 @default.
• W2073511211 creator A5045119784 @default.
• W2073511211 creator A5051075689 @default.
• W2073511211 date "2014-12-11" @default.
• W2073511211 modified "2023-10-01" @default.
• W2073511211 title "Molecular Insights into the Dynamics of Pharmacogenetically Important N-Terminal Variants of the Human β2-Adrenergic Receptor" @default.
• W2073511211 cites W1601495365 @default.
• W2073511211 cites W1603274157 @default.
• W2073511211 cites W1825353903 @default.
• W2073511211 cites W1965984853 @default.
• W2073511211 cites W1968682237 @default.
• W2073511211 cites W1970613671 @default.
• W2073511211 cites W1975732928 @default.
• W2073511211 cites W1976198657 @default.
• W2073511211 cites W1980374511 @default.
• W2073511211 cites W1988097700 @default.
• W2073511211 cites W1990813403 @default.
• W2073511211 cites W1991387062 @default.
• W2073511211 cites W1994816216 @default.
• W2073511211 cites W1995816895 @default.
• W2073511211 cites W1997340548 @default.
• W2073511211 cites W2004334951 @default.
• W2073511211 cites W2006998486 @default.
• W2073511211 cites W2012959970 @default.
• W2073511211 cites W2018762866 @default.
• W2073511211 cites W2020601776 @default.
• W2073511211 cites W2029667189 @default.
• W2073511211 cites W2035266068 @default.
• W2073511211 cites W2035687084 @default.
• W2073511211 cites W2035939859 @default.
• W2073511211 cites W2039812658 @default.
• W2073511211 cites W2049617698 @default.
• W2073511211 cites W2050199670 @default.
• W2073511211 cites W2060874643 @default.
• W2073511211 cites W2067805628 @default.
• W2073511211 cites W2069677629 @default.
• W2073511211 cites W2073110681 @default.
• W2073511211 cites W2078876572 @default.
• W2073511211 cites W2080231167 @default.
• W2073511211 cites W2081645999 @default.
• W2073511211 cites W2086946786 @default.
• W2073511211 cites W2095237667 @default.
• W2073511211 cites W2102377211 @default.
• W2073511211 cites W2105850024 @default.
• W2073511211 cites W2117003397 @default.
• W2073511211 cites W2122671870 @default.
• W2073511211 cites W2125399699 @default.
• W2073511211 cites W2141920771 @default.
• W2073511211 cites W2157226274 @default.
• W2073511211 cites W2158076215 @default.
• W2073511211 cites W2160544821 @default.
• W2073511211 cites W2167857702 @default.
• W2073511211 cites W2168966210 @default.
• W2073511211 cites W2170033400 @default.
• W2073511211 cites W2172509713 @default.
• W2073511211 cites W3100271906 @default.
• W2073511211 cites W35537551 @default.
• W2073511211 cites W4249658209 @default.
• W2073511211 doi "https://doi.org/10.1371/journal.pcbi.1004006" @default.
• W2073511211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4263363" @default.
• W2073511211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25501358" @default.
• W2073511211 hasPublicationYear "2014" @default.
• W2073511211 type Work @default.
• W2073511211 sameAs 2073511211 @default.
• W2073511211 citedByCount "25" @default.
• W2073511211 countsByYear W20735112112015 @default.
• W2073511211 countsByYear W20735112112016 @default.
• W2073511211 countsByYear W20735112112017 @default.
• W2073511211 countsByYear W20735112112018 @default.
• W2073511211 countsByYear W20735112112019 @default.
• W2073511211 countsByYear W20735112112020 @default.
• W2073511211 countsByYear W20735112112021 @default.
• W2073511211 countsByYear W20735112112022 @default.
• W2073511211 countsByYear W20735112112023 @default.
• W2073511211 crossrefType "journal-article" @default.
• W2073511211 hasAuthorship W2073511211A5024022206 @default.
• W2073511211 hasAuthorship W2073511211A5040581077 @default.
• W2073511211 hasAuthorship W2073511211A5045119784 @default.
• W2073511211 hasAuthorship W2073511211A5051075689 @default.
• W2073511211 hasBestOaLocation W20735112111 @default.
• W2073511211 hasConcept C135285700 @default.
• W2073511211 hasConcept C147597530 @default.
• W2073511211 hasConcept C159110408 @default.
• W2073511211 hasConcept C170493617 @default.
• W2073511211 hasConcept C185592680 @default.
• W2073511211 hasConcept C2778938600 @default.
• W2073511211 hasConcept C3018209156 @default.
• W2073511211 hasConcept C41685203 @default.
• W2073511211 hasConcept C54355233 @default.
• W2073511211 hasConcept C59593255 @default.
• W2073511211 hasConcept C70721500 @default.
• W2073511211 hasConcept C71924100 @default.
• W2073511211 hasConcept C86803240 @default.
• W2073511211 hasConceptScore W2073511211C135285700 @default.
• W2073511211 hasConceptScore W2073511211C147597530 @default.

• next