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- W2073516062 abstract "Human intercellular adhesion molecule-1 (ICAM-1), a transmembrane glycoprotein that functions as a ligand for lymphocyte function-associated antigen-1, plays an important role in mediating cell-cell interactions in inflammatory reactions. It is induced by proinflammatory cytokines such as interleukin-1, tumor necrosis factor-α or interferon-γ, as well as by phorbol esters, retinoic acid and lipopolysaccharide. Furthermore, ICAM-1 is upregulated by interleukin-6, which suggests that it belongs to the family of acute phase response genes. Investigation of the 5′ -regulatory region of the human ICAM-1 gene revealed sequence motifs for a variety of transcription factors implicated in transcriptional regulation. This review summarizes the current knowledge of the transcriptional regulation of the human ICAM-1 gene." @default.
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- W2073516062 date "1995-07-01" @default.
- W2073516062 modified "2023-10-16" @default.
- W2073516062 title "Transcriptional Regulation of the Human Intercellular Adhesion Molecule-1 Gene: A Short Overview" @default.
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- W2073516062 doi "https://doi.org/10.1016/s0171-2985(11)80558-9" @default.
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