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- W2073520007 abstract "Aging is associated with a progressive and involuntary loss of muscle mass also known as sarcopenia. This condition represents a major public health concern. Although sarcopenia is well documented, the molecular mechanisms of this condition still remain unclear. The calcium-dependent proteolytic system is composed of calcium-dependent cysteine proteases named calpains. Calpains are involved in a large number of physiological processes such as muscle growth and differentiation, and pathological conditions such as muscular dystrophies. The aim of this study was to determine the involvement of this proteolytic system in the phenotype associated with sarcopenia by identifying key proteins (substrates or regulators) interacting with calpains during muscle aging. Immunoprecipitations coupled with proteomic analyses and protein identification by mass spectrometry have been undertaken. Reverse co-immunoprecipitation, cellular colocalisation by confocal microscopy and calpain-dependent in vitro proteolysis of several of the identified proteins have been also carried out. We identified ATP synthase subunit alpha and alpha actinin 3 as key partners of calpains during muscle aging. Such interactions would suggest that calpains are implicated in many processes altered during aging including cytoskeletal disorganisation and mitochondrial dysfunction." @default.
- W2073520007 created "2016-06-24" @default.
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- W2073520007 date "2010-12-01" @default.
- W2073520007 modified "2023-10-18" @default.
- W2073520007 title "Proteomic study of calpain interacting proteins during skeletal muscle aging" @default.
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- W2073520007 cites W1508162082 @default.
- W2073520007 cites W1694814481 @default.
- W2073520007 cites W1884779781 @default.
- W2073520007 cites W1941910566 @default.
- W2073520007 cites W1966759762 @default.
- W2073520007 cites W1968815565 @default.
- W2073520007 cites W1983334596 @default.
- W2073520007 cites W1986087959 @default.
- W2073520007 cites W1992878854 @default.
- W2073520007 cites W2000590667 @default.
- W2073520007 cites W2002047119 @default.
- W2073520007 cites W2002697895 @default.
- W2073520007 cites W2004844748 @default.
- W2073520007 cites W2007604900 @default.
- W2073520007 cites W2011254745 @default.
- W2073520007 cites W2012465360 @default.
- W2073520007 cites W2016595949 @default.
- W2073520007 cites W2023421441 @default.
- W2073520007 cites W2025542017 @default.
- W2073520007 cites W2036105711 @default.
- W2073520007 cites W2039466240 @default.
- W2073520007 cites W2042533702 @default.
- W2073520007 cites W2043074525 @default.
- W2073520007 cites W2045293495 @default.
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- W2073520007 cites W2064193871 @default.
- W2073520007 cites W2067254948 @default.
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- W2073520007 cites W2069661739 @default.
- W2073520007 cites W2072992379 @default.
- W2073520007 cites W2075751992 @default.
- W2073520007 cites W2081818871 @default.
- W2073520007 cites W2083403855 @default.
- W2073520007 cites W2083603036 @default.
- W2073520007 cites W2084776606 @default.
- W2073520007 cites W2088050180 @default.
- W2073520007 cites W2096094625 @default.
- W2073520007 cites W2096856754 @default.
- W2073520007 cites W2096871163 @default.
- W2073520007 cites W2099028319 @default.
- W2073520007 cites W2099195203 @default.
- W2073520007 cites W2100381069 @default.
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- W2073520007 cites W2107575131 @default.
- W2073520007 cites W2107596619 @default.
- W2073520007 cites W2111617373 @default.
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- W2073520007 cites W2116382217 @default.
- W2073520007 cites W2120905810 @default.
- W2073520007 cites W2133145432 @default.
- W2073520007 cites W2135377155 @default.
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- W2073520007 cites W2139337253 @default.
- W2073520007 cites W2140715527 @default.
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- W2073520007 doi "https://doi.org/10.1016/j.biochi.2010.09.003" @default.
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