Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073526315> ?p ?o ?g. }
- W2073526315 endingPage "120" @default.
- W2073526315 startingPage "88" @default.
- W2073526315 abstract "Endogenous factors, including hormones, growth factors and cytokines, play an important role in the regulation of hepatic drug metabolizing enzyme expression in both physiological and pathophysiological conditions. Diabetes, fasting, obesity, protein-calorie malnutrition and long-term alcohol consumption produce changes in hepatic drug metabolizing enzyme gene and protein expression. This difference in expression alters the metabolism of xenobiotics, including procarcinogens, carcinogens, toxicants and therapeutic agents, potentially impacting the efficacy and safety of therapeutic agents, and/or resulting in drug-drug interactions. Although the mechanisms by which xenobiotics regulate drug metabolizing enzymes have been studied intensively, less is known regarding the cellular signaling pathways and components which regulate drug metabolizing enzyme gene and protein expression in response to hormones and cytokines. Recent findings, however, have revealed that several cellular signaling pathways are involved in hormone- and growth factor-mediated regulation of drug metabolizing enzymes. Our laboratory has reported that insulin and growth factors regulate drug metabolizing enzyme gene and protein expression, including cytochromes P450 (CYP), glutathione S-transferases (GST) and microsomal epoxide hydrolase (mEH), through receptors which are members of the large receptor tyrosine kinase (RTK) family, and by downstream effectors such as phosphatidylinositol 3-kinase, mitogen activated protein kinase (MAPK), Akt/protein kinase B (PKB), mammalian target of rapamycin (mTOR), and the p70 ribosomal protein S6 kinase (p70S6 kinase). Here, we review current knowledge of the signaling pathways implicated in regulation of drug metabolizing enzyme gene and protein expression in response to insulin and growth factors, with the goal of increasing our understanding of how disease affects these signaling pathways, components, and ultimately gene expression and translational control." @default.
- W2073526315 created "2016-06-24" @default.
- W2073526315 creator A5004964002 @default.
- W2073526315 creator A5026715008 @default.
- W2073526315 date "2007-01-01" @default.
- W2073526315 modified "2023-10-10" @default.
- W2073526315 title "The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression" @default.
- W2073526315 cites W104690111 @default.
- W2073526315 cites W127412036 @default.
- W2073526315 cites W1481314844 @default.
- W2073526315 cites W1487264337 @default.
- W2073526315 cites W150879800 @default.
- W2073526315 cites W1529396499 @default.
- W2073526315 cites W1556769606 @default.
- W2073526315 cites W1566025256 @default.
- W2073526315 cites W1566737177 @default.
- W2073526315 cites W1572009433 @default.
- W2073526315 cites W1573413160 @default.
- W2073526315 cites W1576004006 @default.
- W2073526315 cites W1577373236 @default.
- W2073526315 cites W1586884884 @default.
- W2073526315 cites W1587753447 @default.
- W2073526315 cites W1597498191 @default.
- W2073526315 cites W1605111896 @default.
- W2073526315 cites W1666849257 @default.
- W2073526315 cites W1726025741 @default.
- W2073526315 cites W1813297717 @default.
- W2073526315 cites W1836212818 @default.
- W2073526315 cites W1849821171 @default.
- W2073526315 cites W1898413089 @default.
- W2073526315 cites W1898522670 @default.
- W2073526315 cites W1906150121 @default.
- W2073526315 cites W1909763738 @default.
- W2073526315 cites W1928407971 @default.
- W2073526315 cites W1930719756 @default.
- W2073526315 cites W1964740016 @default.
- W2073526315 cites W1968054389 @default.
- W2073526315 cites W1968991720 @default.
- W2073526315 cites W1969032539 @default.
- W2073526315 cites W1969388212 @default.
- W2073526315 cites W1969442037 @default.
- W2073526315 cites W1970170878 @default.
- W2073526315 cites W1970384979 @default.
- W2073526315 cites W1970996453 @default.
- W2073526315 cites W1971047268 @default.
- W2073526315 cites W1971390138 @default.
- W2073526315 cites W1971529620 @default.
- W2073526315 cites W1971614014 @default.
- W2073526315 cites W1972811295 @default.
- W2073526315 cites W1972812612 @default.
- W2073526315 cites W1973837499 @default.
- W2073526315 cites W1975573101 @default.
- W2073526315 cites W1976508327 @default.
- W2073526315 cites W1979532631 @default.
- W2073526315 cites W1979910666 @default.
- W2073526315 cites W1981468543 @default.
- W2073526315 cites W1982003968 @default.
- W2073526315 cites W1982925651 @default.
- W2073526315 cites W1982968521 @default.
- W2073526315 cites W1983568538 @default.
- W2073526315 cites W1983597478 @default.
- W2073526315 cites W1985325808 @default.
- W2073526315 cites W1986040000 @default.
- W2073526315 cites W1987105275 @default.
- W2073526315 cites W1988051941 @default.
- W2073526315 cites W1990558693 @default.
- W2073526315 cites W1990841830 @default.
- W2073526315 cites W1991938984 @default.
- W2073526315 cites W1992507055 @default.
- W2073526315 cites W1996160829 @default.
- W2073526315 cites W1996979039 @default.
- W2073526315 cites W1997656209 @default.
- W2073526315 cites W1997794911 @default.
- W2073526315 cites W1998355732 @default.
- W2073526315 cites W1998677576 @default.
- W2073526315 cites W1998917481 @default.
- W2073526315 cites W1999163644 @default.
- W2073526315 cites W1999286346 @default.
- W2073526315 cites W1999441881 @default.
- W2073526315 cites W1999447199 @default.
- W2073526315 cites W2000348274 @default.
- W2073526315 cites W2000440562 @default.
- W2073526315 cites W2004863760 @default.
- W2073526315 cites W2005076200 @default.
- W2073526315 cites W2006227722 @default.
- W2073526315 cites W2006304210 @default.
- W2073526315 cites W2006559495 @default.
- W2073526315 cites W2007551386 @default.
- W2073526315 cites W2008130390 @default.
- W2073526315 cites W2008530488 @default.
- W2073526315 cites W2010489503 @default.
- W2073526315 cites W2011282245 @default.
- W2073526315 cites W2011312875 @default.
- W2073526315 cites W2011588737 @default.
- W2073526315 cites W2011793316 @default.
- W2073526315 cites W2011842753 @default.
- W2073526315 cites W201204992 @default.
- W2073526315 cites W2012142261 @default.