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- W2073529464 abstract "When sperm activate eggs at fertilization the signal for activation involves increases in the intracellular free Ca 2+ concentration. In mammals the Ca 2+ changes at fertilization consist of intracellular Ca 2+ oscillations that are driven by the generation of inositol 1,4,5-trisphosphate (InsP 3 ). It is not established how sperm trigger the increases in InsP 3 and Ca 2+ at fertilization. One theory suggests that sperm initiate signals to activate the egg by introducing a specific factor into the egg cytoplasm after membrane fusion. This theory has been mainly based upon the observation that injecting a cytosolic sperm protein factor into eggs can trigger the same pattern of Ca 2+ oscillations induced by the sperm. We have recently shown that this soluble sperm factor protein is a novel form of phospholipase C (PLC), and it is referred to as PLCζ(zeta). We describe the evidence that led to the identification of PLCζ and discuss the issues relating to its potential role in fertilization." @default.
- W2073529464 created "2016-06-24" @default.
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- W2073529464 date "2004-04-01" @default.
- W2073529464 modified "2023-09-24" @default.
- W2073529464 title "The cytosolic sperm factor that triggers Ca2+ oscillations and egg activation in mammals is a novel phospholipase C: PLCζ" @default.
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- W2073529464 doi "https://doi.org/10.1530/rep.1.00169" @default.
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