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• W2073532261 abstract "Many agents using tumour-associated characteristics are deposited heterogeneously within tumour tissue. Consequently, tumour heterogeneity should be addressed when obtaining information on tumour biology or relating absorbed radiation dose to biological effect. We present a technique that enables radioluminographs of serial tumour sections to be reconstructed using automated computerized techniques, resulting in a three-dimensional map of the dose-rate distribution of a radiolabelled antibody. The purpose of this study is to assess the reconstruction accuracy. Furthermore, we estimate the potential error resulting from registration misalignment, for a range of beta-emitting radionuclides. We compare the actual dose-rate distribution with that obtained from the same activity distribution but with manually defined translational and rotational shifts. As expected, the error produced with the short-range 14C is much larger than that for the longer range 90Y; similarly values for the medium range 131I are between the two. Thus, the impact of registration inaccuracies is greater for short-range sources." @default.
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• W2073532261 date "2002-10-01" @default.
• W2073532261 modified "2023-09-27" @default.
• W2073532261 title "Spatial accuracy of 3D reconstructed radioluminographs of serial tissue sections and resultant absorbed dose estimates" @default.
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• W2073532261 doi "https://doi.org/10.1088/0031-9155/47/20/307" @default.
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