FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073533596> ?p ?o ?g. }

• W2073533596 endingPage "2051" @default.
• W2073533596 startingPage "2045" @default.
• W2073533596 abstract "Mycophenolate mofetil (MMF), an inhibitor of inosine monophosphate dehydrogenase (IMPDH) activity, is usually administered as a standard dose of 1 g b.i.d. after renal transplantation. Because MMF dose reductions are associated with inferior outcome, we investigated pre-transplant IMPDH activity, MMF dose reductions and outcome. IMPDH activity was determined in isolated peripheral mononuclear cells immediately prior to renal transplantation. We observed considerable inter-individual variability in pre-transplant IMPDH activity (9.35 +/- 4.22 nmol/mg/h). Thirty of 48 patients (62.5%) with standard MMF dose (1 g b.i.d.) had dose reductions within 3 years post-transplant; these patients also had significantly lower IMPDH activity. The area under the receiver-operating characteristics curve (AUC-ROC) for prediction of dose reduction within 6 months post-transplant was 0.75 (95% CI, 0.61-0.89; p < 0.004). IMPDH activity above the cut-off value, MMF dose reduction and age of recipient were significant contributors for the occurrence of acute rejection in the multivariate logistic regression. Patients with high IMPDH activity and MMF dose reduction had the highest rejection rate (81.8% vs. 36.4%; p < 0.01).Patients with low IMPDH activity experienced more complications of MMF therapy. High pre-transplant IMPDH activity and MMF dose reductions were associated with rejection. Determination of IMPDH activity prior to transplantation may help to improve MMF therapy after renal transplantation." @default.
• W2073533596 created "2016-06-24" @default.
• W2073533596 creator A5009035817 @default.
• W2073533596 creator A5028955388 @default.
• W2073533596 creator A5036575893 @default.
• W2073533596 creator A5047781367 @default.
• W2073533596 creator A5049924535 @default.
• W2073533596 creator A5054885532 @default.
• W2073533596 creator A5060425510 @default.
• W2073533596 creator A5065115970 @default.
• W2073533596 creator A5084827547 @default.
• W2073533596 creator A5087915335 @default.
• W2073533596 date "2004-12-01" @default.
• W2073533596 modified "2023-10-16" @default.
• W2073533596 title "Pre-Transplant Inosine Monophosphate Dehydrogenase Activity is Associated with Clinical Outcome After Renal Transplantation" @default.
• W2073533596 cites W193850055 @default.
• W2073533596 cites W1955028047 @default.
• W2073533596 cites W1971018450 @default.
• W2073533596 cites W1981535286 @default.
• W2073533596 cites W1991303398 @default.
• W2073533596 cites W1993267820 @default.
• W2073533596 cites W1995791071 @default.
• W2073533596 cites W2001349326 @default.
• W2073533596 cites W2001930080 @default.
• W2073533596 cites W2014196033 @default.
• W2073533596 cites W2025501899 @default.
• W2073533596 cites W2026162105 @default.
• W2073533596 cites W2039029671 @default.
• W2073533596 cites W2056054156 @default.
• W2073533596 cites W2061904336 @default.
• W2073533596 cites W2075889080 @default.
• W2073533596 cites W2131017985 @default.
• W2073533596 cites W2164119724 @default.
• W2073533596 cites W2170730772 @default.
• W2073533596 cites W2171923114 @default.
• W2073533596 cites W2324505043 @default.
• W2073533596 cites W2410816895 @default.
• W2073533596 cites W2609602266 @default.
• W2073533596 cites W4230996310 @default.
• W2073533596 cites W50336179 @default.
• W2073533596 doi "https://doi.org/10.1111/j.1600-6143.2004.00617.x" @default.
• W2073533596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15575908" @default.
• W2073533596 hasPublicationYear "2004" @default.
• W2073533596 type Work @default.
• W2073533596 sameAs 2073533596 @default.
• W2073533596 citedByCount "147" @default.
• W2073533596 countsByYear W20735335962012 @default.
• W2073533596 countsByYear W20735335962013 @default.
• W2073533596 countsByYear W20735335962014 @default.
• W2073533596 countsByYear W20735335962015 @default.
• W2073533596 countsByYear W20735335962016 @default.
• W2073533596 countsByYear W20735335962018 @default.
• W2073533596 countsByYear W20735335962019 @default.
• W2073533596 countsByYear W20735335962020 @default.
• W2073533596 countsByYear W20735335962021 @default.
• W2073533596 countsByYear W20735335962022 @default.
• W2073533596 countsByYear W20735335962023 @default.
• W2073533596 crossrefType "journal-article" @default.
• W2073533596 hasAuthorship W2073533596A5009035817 @default.
• W2073533596 hasAuthorship W2073533596A5028955388 @default.
• W2073533596 hasAuthorship W2073533596A5036575893 @default.
• W2073533596 hasAuthorship W2073533596A5047781367 @default.
• W2073533596 hasAuthorship W2073533596A5049924535 @default.
• W2073533596 hasAuthorship W2073533596A5054885532 @default.
• W2073533596 hasAuthorship W2073533596A5060425510 @default.
• W2073533596 hasAuthorship W2073533596A5065115970 @default.
• W2073533596 hasAuthorship W2073533596A5084827547 @default.
• W2073533596 hasAuthorship W2073533596A5087915335 @default.
• W2073533596 hasBestOaLocation W20735335961 @default.
• W2073533596 hasConcept C104317684 @default.
• W2073533596 hasConcept C126322002 @default.
• W2073533596 hasConcept C126894567 @default.
• W2073533596 hasConcept C185592680 @default.
• W2073533596 hasConcept C2778033501 @default.
• W2073533596 hasConcept C2909748322 @default.
• W2073533596 hasConcept C2909935303 @default.
• W2073533596 hasConcept C2911091166 @default.
• W2073533596 hasConcept C38596361 @default.
• W2073533596 hasConcept C512185932 @default.
• W2073533596 hasConcept C55493867 @default.
• W2073533596 hasConcept C71924100 @default.
• W2073533596 hasConcept C90924648 @default.
• W2073533596 hasConcept C98274493 @default.
• W2073533596 hasConceptScore W2073533596C104317684 @default.
• W2073533596 hasConceptScore W2073533596C126322002 @default.
• W2073533596 hasConceptScore W2073533596C126894567 @default.
• W2073533596 hasConceptScore W2073533596C185592680 @default.
• W2073533596 hasConceptScore W2073533596C2778033501 @default.
• W2073533596 hasConceptScore W2073533596C2909748322 @default.
• W2073533596 hasConceptScore W2073533596C2909935303 @default.
• W2073533596 hasConceptScore W2073533596C2911091166 @default.
• W2073533596 hasConceptScore W2073533596C38596361 @default.
• W2073533596 hasConceptScore W2073533596C512185932 @default.
• W2073533596 hasConceptScore W2073533596C55493867 @default.
• W2073533596 hasConceptScore W2073533596C71924100 @default.
• W2073533596 hasConceptScore W2073533596C90924648 @default.
• W2073533596 hasConceptScore W2073533596C98274493 @default.
• W2073533596 hasIssue "12" @default.

• next