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• W2073534787 abstract "Background: Enhanced external counterpulsation (EECP) is a noninvasive, outpatient treatment designed to increase myocardial perfusion pressure and decrease cardiac workload. EECP has been demonstrated to be safe, well tolerated and effective for the relief of angina in patients with left ventricular dysfunction (LVD). We examined the therapeutic efficacy of EECP on patient functional status and quality of life as assessed by the Duke Activity Status Index (DASI), a standardized assessment of functional status that correlates well with peak oxygen uptake (Spearman correlation coefficient, 0.58). Methods: Demographic and clinical outcome data were analyzed on all patients enrolled in the International EECP Patient Registry-2 who had baseline and post-treatment DASI scores. Patients were divided into those with ejection fraction >35% (N = 366) and those with (ejection fraction < = 35%) (LVD) (N = 111). Results: At baseline those patients with LVD were significantly more likely to have had prior myocardial infarction (87% vs 67%, p<0.001), a history of decompensated heart failure (58% vs 25%, p<0.001), and implanted devices: pacemaker (22% vs 8%, p<0.001), defibrillator (16% vs 2.5%, p<0.001). They experienced a mean of 10 episodes of angina/week despite optimum medical management and previous cardiac revascularization. Abnormal cardiac rhythm was reported in greater than 20% of patients with LVD. Mean ejection fraction was 26% (range 10-35%) for LVD vs 54% (range 36-88%) for no LVD. Most patients with LVD were able to complete a course of EECP(75% vs 85%, p<0.05); however, 3.7% experienced exacerbation of heart failure symptoms during the treatment period. Reduction in angina (>=1 Canadian Cardiovascular Society class) was achieved in both groups (73% vs 76%, p = NS). By DASI assessment at baseline, patients in both groups were markedly limited in functional capacity (median DASI score of 7.3 for patients with LVD vs 10.0 for patients without LVD) (out of a possible score of 58.2). Post-EECP, there was a significant (p<0.001) improvement in the DASI scores in both groups. Patients with ejection fraction >35% improved in 63% of cases with a median DASI score of 15.4. Fifty-nine percent of the LVD group experienced improvement in functional status, with a median DASI score post-EECP of 13.5. Conclusion: EECP improves functional capacity and quality of life as assessed by the DASI questionnaire which correlates with peak oxygen uptake. EECP safely and effectively extends treatment options for angina in patients with LVD and provides improvement in the patient's actual disability as measured by ability to perform a variety of common activities." @default.
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• W2073534787 date "2003-10-01" @default.
• W2073534787 modified "2023-10-18" @default.
• W2073534787 title "Enhanced External Counterpulsation Improves Functional Capacity in Patients with Left Ventricular Dysfunction as Assessed by the Duke Activity Status Index - A Questionnaire Correlated with Peak Oxygen Uptake" @default.
• W2073534787 doi "https://doi.org/10.1016/s1071-9164(03)00221-5" @default.
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