FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073540068> ?p ?o ?g. }

• W2073540068 endingPage "154" @default.
• W2073540068 startingPage "144" @default.
• W2073540068 abstract "Mutations in the extracellular matrix molecule collagen VI underlie the congenital muscular dystrophy types Ullrich and Bethlem. Establishing the origin of collagen VI in muscle is important for understanding the pathophysiology of these diseases and for developing future treatment approaches involving cell-specific delivery. Because the cells that produce collagen VI cannot be identified by histologic analysis, we examined the production of collagen VI in pure cultures of primary myogenic cells and muscle interstitial fibroblasts from limb muscle of neonatal mice. Immunofluorescence staining and Western blot analysis revealed secretion and matrix deposition of collagen VI by interstitial fibroblasts but not by myogenic cells in vitro. Using Northern blot and real-time reverse-transcriptase-polymerase chain reaction analysis for the collagen VI genes col6a1, col6a2, col6a3, transcript levels for the 3 mRNAs were high in interstitial fibroblasts, whereas in primary myogenic cells, they were indistinguishable from background. Furthermore, retention of mutant collagen VI in muscle from 3 patients with collagen VI mutation was identified in interstitial fibroblastic cells but not in their myofibers. These results suggest that interstitial fibroblasts but not myogenic cells contribute significantly to the deposition of collagen VI in the extracellular matrix in skeletal muscle and imply major roles of this cell type and the extracellular matrix in the pathogenesis of these diseases." @default.
• W2073540068 created "2016-06-24" @default.
• W2073540068 creator A5043625969 @default.
• W2073540068 creator A5059907230 @default.
• W2073540068 creator A5066607827 @default.
• W2073540068 creator A5077449768 @default.
• W2073540068 creator A5084817734 @default.
• W2073540068 date "2008-02-01" @default.
• W2073540068 modified "2023-10-12" @default.
• W2073540068 title "Muscle Interstitial Fibroblasts Are the Main Source of Collagen VI Synthesis in Skeletal Muscle: Implications for Congenital Muscular Dystrophy Types Ullrich and Bethlem" @default.
• W2073540068 cites W1500524081 @default.
• W2073540068 cites W1834208879 @default.
• W2073540068 cites W1967399157 @default.
• W2073540068 cites W1972984824 @default.
• W2073540068 cites W1973087217 @default.
• W2073540068 cites W1980193533 @default.
• W2073540068 cites W1980474802 @default.
• W2073540068 cites W1981152176 @default.
• W2073540068 cites W1981910778 @default.
• W2073540068 cites W1985390736 @default.
• W2073540068 cites W1986544095 @default.
• W2073540068 cites W1991909948 @default.
• W2073540068 cites W1993398173 @default.
• W2073540068 cites W1997695989 @default.
• W2073540068 cites W2002343714 @default.
• W2073540068 cites W2011678345 @default.
• W2073540068 cites W2015040091 @default.
• W2073540068 cites W2025622374 @default.
• W2073540068 cites W2025986180 @default.
• W2073540068 cites W2032607799 @default.
• W2073540068 cites W2040718007 @default.
• W2073540068 cites W2042258234 @default.
• W2073540068 cites W2056652025 @default.
• W2073540068 cites W2060443399 @default.
• W2073540068 cites W2062089915 @default.
• W2073540068 cites W2062867597 @default.
• W2073540068 cites W2064009495 @default.
• W2073540068 cites W2066408350 @default.
• W2073540068 cites W2068886984 @default.
• W2073540068 cites W2071902795 @default.
• W2073540068 cites W2078618770 @default.
• W2073540068 cites W2081331195 @default.
• W2073540068 cites W2083405476 @default.
• W2073540068 cites W2101896709 @default.
• W2073540068 cites W2106231162 @default.
• W2073540068 cites W2107277218 @default.
• W2073540068 cites W2108723188 @default.
• W2073540068 cites W2125922121 @default.
• W2073540068 cites W2130036778 @default.
• W2073540068 cites W2131244812 @default.
• W2073540068 cites W2134263002 @default.
• W2073540068 cites W2137284441 @default.
• W2073540068 cites W2142445431 @default.
• W2073540068 cites W2142488497 @default.
• W2073540068 cites W2156497704 @default.
• W2073540068 cites W2157028844 @default.
• W2073540068 cites W2161169921 @default.
• W2073540068 cites W2168782470 @default.
• W2073540068 cites W2170317751 @default.
• W2073540068 cites W2223764435 @default.
• W2073540068 cites W2397992179 @default.
• W2073540068 cites W94861597 @default.
• W2073540068 doi "https://doi.org/10.1097/nen.0b013e3181634ef7" @default.
• W2073540068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18219255" @default.
• W2073540068 hasPublicationYear "2008" @default.
• W2073540068 type Work @default.
• W2073540068 sameAs 2073540068 @default.
• W2073540068 citedByCount "115" @default.
• W2073540068 countsByYear W20735400682012 @default.
• W2073540068 countsByYear W20735400682013 @default.
• W2073540068 countsByYear W20735400682014 @default.
• W2073540068 countsByYear W20735400682015 @default.
• W2073540068 countsByYear W20735400682016 @default.
• W2073540068 countsByYear W20735400682017 @default.
• W2073540068 countsByYear W20735400682018 @default.
• W2073540068 countsByYear W20735400682019 @default.
• W2073540068 countsByYear W20735400682020 @default.
• W2073540068 countsByYear W20735400682021 @default.
• W2073540068 countsByYear W20735400682022 @default.
• W2073540068 countsByYear W20735400682023 @default.
• W2073540068 crossrefType "journal-article" @default.
• W2073540068 hasAuthorship W2073540068A5043625969 @default.
• W2073540068 hasAuthorship W2073540068A5059907230 @default.
• W2073540068 hasAuthorship W2073540068A5066607827 @default.
• W2073540068 hasAuthorship W2073540068A5077449768 @default.
• W2073540068 hasAuthorship W2073540068A5084817734 @default.
• W2073540068 hasBestOaLocation W20735400681 @default.
• W2073540068 hasConcept C104317684 @default.
• W2073540068 hasConcept C134018914 @default.
• W2073540068 hasConcept C142724271 @default.
• W2073540068 hasConcept C153911025 @default.
• W2073540068 hasConcept C181709278 @default.
• W2073540068 hasConcept C185592680 @default.
• W2073540068 hasConcept C189165786 @default.
• W2073540068 hasConcept C202751555 @default.
• W2073540068 hasConcept C207200792 @default.
• W2073540068 hasConcept C2776415932 @default.
• W2073540068 hasConcept C2777534427 @default.

• next