FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073544174> ?p ?o ?g. }

• W2073544174 endingPage "e80738" @default.
• W2073544174 startingPage "e80738" @default.
• W2073544174 abstract "Aims MicroRNAs (miRNAs) play important roles in the pathogenesis of cardiovascular diseases. Circulating miRNAs were recently identified as biomarkers for various physiological and pathological conditions. In this study, we aimed to identify the circulating miRNA fingerprint of vulnerable coronary artery disease (CAD) and explore its potential as a novel biomarker for this disease. Methods and Results The Taqman low-density miRNA array and coexpression network analyses were used to identify distinct miRNA expression profiles in the plasma of patients with typical unstable angina (UA) and angiographically documented CAD (UA group, n = 13) compared to individuals with non-cardiac chest pain (control group, n = 13). Significantly elevated expression levels of miR-106b/25 cluster, miR-17/92a cluster, miR-21/590-5p family, miR-126*, and miR-451 were observed in UA patients compared to controls. These findings were validated by real-time PCR in another 45 UA patients, 31 stable angina patients, and 37 controls. In addition, miR-106b, miR-25, miR-92a, miR-21, miR-590-5p, miR-126* and miR-451 were upregulated in microparticles (MPs) isolated from the plasma of UA patients (n = 5) compared to controls (n = 5). Using flow cytometry and immunolabeling, we further found that Annexin V+ MPs were increased in the plasma samples of UA patients compared to controls, and the majority of the increased MPs in plasma were shown to be Annexin V+ CD31+ MPs. The findings suggest that Annexin V+ CD31+ MPs may contribute to the elevated expression of the selected miRNAs in the circulation of patients with vulnerable CAD. Conclusion The circulating miRNA signature, consisting of the miR-106b/25 cluster, miR-17/92a cluster, miR-21/590-5p family, miR-126* and miR-451, may be used as a novel biomarker for vulnerable CAD. Trial Registration Chinese Clinical Trial Register, ChiCTR-OCH-12002349." @default.
• W2073544174 created "2016-06-24" @default.
• W2073544174 creator A5003473928 @default.
• W2073544174 creator A5007957103 @default.
• W2073544174 creator A5008702027 @default.
• W2073544174 creator A5010779145 @default.
• W2073544174 creator A5023931244 @default.
• W2073544174 creator A5031913917 @default.
• W2073544174 creator A5036715451 @default.
• W2073544174 creator A5064530138 @default.
• W2073544174 creator A5089718840 @default.
• W2073544174 date "2013-12-05" @default.
• W2073544174 modified "2023-10-02" @default.
• W2073544174 title "Signature of Circulating MicroRNAs as Potential Biomarkers in Vulnerable Coronary Artery Disease" @default.
• W2073544174 cites W144423133 @default.
• W2073544174 cites W1525488943 @default.
• W2073544174 cites W1963906441 @default.
• W2073544174 cites W1968772146 @default.
• W2073544174 cites W1971726501 @default.
• W2073544174 cites W1989910375 @default.
• W2073544174 cites W1993853627 @default.
• W2073544174 cites W2015547750 @default.
• W2073544174 cites W2017426710 @default.
• W2073544174 cites W2032696674 @default.
• W2073544174 cites W2034679507 @default.
• W2073544174 cites W2051389951 @default.
• W2073544174 cites W2055670205 @default.
• W2073544174 cites W2090761865 @default.
• W2073544174 cites W2096513091 @default.
• W2073544174 cites W2101458205 @default.
• W2073544174 cites W2109196617 @default.
• W2073544174 cites W2109341154 @default.
• W2073544174 cites W2115093090 @default.
• W2073544174 cites W2117890823 @default.
• W2073544174 cites W2120439472 @default.
• W2073544174 cites W2126336279 @default.
• W2073544174 cites W2126494270 @default.
• W2073544174 cites W2126601545 @default.
• W2073544174 cites W2127179562 @default.
• W2073544174 cites W2130330362 @default.
• W2073544174 cites W2133478942 @default.
• W2073544174 cites W2148912798 @default.
• W2073544174 cites W2150540679 @default.
• W2073544174 cites W2154381563 @default.
• W2073544174 cites W2163655902 @default.
• W2073544174 doi "https://doi.org/10.1371/journal.pone.0080738" @default.
• W2073544174 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3855151" @default.
• W2073544174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24339880" @default.
• W2073544174 hasPublicationYear "2013" @default.
• W2073544174 type Work @default.
• W2073544174 sameAs 2073544174 @default.
• W2073544174 citedByCount "163" @default.
• W2073544174 countsByYear W20735441742014 @default.
• W2073544174 countsByYear W20735441742015 @default.
• W2073544174 countsByYear W20735441742016 @default.
• W2073544174 countsByYear W20735441742017 @default.
• W2073544174 countsByYear W20735441742018 @default.
• W2073544174 countsByYear W20735441742019 @default.
• W2073544174 countsByYear W20735441742020 @default.
• W2073544174 countsByYear W20735441742021 @default.
• W2073544174 countsByYear W20735441742022 @default.
• W2073544174 countsByYear W20735441742023 @default.
• W2073544174 crossrefType "journal-article" @default.
• W2073544174 hasAuthorship W2073544174A5003473928 @default.
• W2073544174 hasAuthorship W2073544174A5007957103 @default.
• W2073544174 hasAuthorship W2073544174A5008702027 @default.
• W2073544174 hasAuthorship W2073544174A5010779145 @default.
• W2073544174 hasAuthorship W2073544174A5023931244 @default.
• W2073544174 hasAuthorship W2073544174A5031913917 @default.
• W2073544174 hasAuthorship W2073544174A5036715451 @default.
• W2073544174 hasAuthorship W2073544174A5064530138 @default.
• W2073544174 hasAuthorship W2073544174A5089718840 @default.
• W2073544174 hasBestOaLocation W20735441741 @default.
• W2073544174 hasConcept C104317684 @default.
• W2073544174 hasConcept C126322002 @default.
• W2073544174 hasConcept C142724271 @default.
• W2073544174 hasConcept C143998085 @default.
• W2073544174 hasConcept C145059251 @default.
• W2073544174 hasConcept C164705383 @default.
• W2073544174 hasConcept C2777785093 @default.
• W2073544174 hasConcept C2778213512 @default.
• W2073544174 hasConcept C2780942790 @default.
• W2073544174 hasConcept C2781197716 @default.
• W2073544174 hasConcept C500558357 @default.
• W2073544174 hasConcept C55493867 @default.
• W2073544174 hasConcept C60644358 @default.
• W2073544174 hasConcept C71924100 @default.
• W2073544174 hasConcept C86803240 @default.
• W2073544174 hasConceptScore W2073544174C104317684 @default.
• W2073544174 hasConceptScore W2073544174C126322002 @default.
• W2073544174 hasConceptScore W2073544174C142724271 @default.
• W2073544174 hasConceptScore W2073544174C143998085 @default.
• W2073544174 hasConceptScore W2073544174C145059251 @default.
• W2073544174 hasConceptScore W2073544174C164705383 @default.
• W2073544174 hasConceptScore W2073544174C2777785093 @default.
• W2073544174 hasConceptScore W2073544174C2778213512 @default.
• W2073544174 hasConceptScore W2073544174C2780942790 @default.
• W2073544174 hasConceptScore W2073544174C2781197716 @default.

• next