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- W2073544207 abstract "Baroreflex sensitivity (BRS), exercise pressor reflex (EPR), and aging influence the autonomic nervous response associated with orthostatic maneuvers. Standing significantly increases heart rate (HR), with an initial increase (1.deltaHR) due to EPR and a secondary, more gradual increase (2.deltaHR) due to BRS. HR then decreases (3.deltaHR), which is also attributable to BRS. Thus far, however, few data are available regarding the interdependence of these variables.Ninety-five healthy volunteers (mean age 37 +/- 11 years, range 10-70 years; 50 women) underwent continuous noninvasive measurements of beat-to-beat blood pressure, HR, and spontaneous BRS in the supine (10 minutes) and upright (10 minutes) positions. After tilt, 1.deltaHR, 2.deltaHR, and 3.deltaHR were calculated from the HR recording. From the 1(st) to the 6(th) decade BRS, 2.deltaHR and 3.deltaHR decreased with normal aging ([BRS 11.88 +/- 7.97 ms/mmHg to 1.81 ms/mmHg, P = 0.006], 2.deltaHR [16.75 +/- 3.40 beats to 5.33 +/- 2.52 beats, P = 0.002], 3.deltaHR [52.25 +/- 5.91 beats to 11.33 +/- 4.04 beats, P < 0.001]). However, no such association was noted between 1.deltaHR and age (21.25 +/- 9.35 beats to 12.00 +/- 7.21 beats, ns). BRS while standing was correlated with 1.deltaHR (r = 0.432, P < 0.001).EPR, in contrast to BRS, was not significantly influenced by normal aging. Furthermore, not only was BRS influenced by EPR, as is generally acknowledged, but EPR and BRS were interrelated. These observations offer new insights into the complex interactions of orthostasis-induced physiological autonomic reflexes associated with normal aging." @default.
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- W2073544207 date "2007-01-01" @default.
- W2073544207 modified "2023-10-14" @default.
- W2073544207 title "Effects of Aging on Reflex Autonomic Nervous Response Induced by Orthostatic Maneuvers" @default.
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- W2073544207 doi "https://doi.org/10.1111/j.1540-8159.2007.00637.x" @default.
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