FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073552393> ?p ?o ?g. }

• W2073552393 endingPage "5204" @default.
• W2073552393 startingPage "5194" @default.
• W2073552393 abstract "PTH and PTH-related peptide (PTHrP) have been shown to bind to and activate the same PTH/PTHrP receptor. Recent studies have demonstrated, however, the presence of additional receptors specific for each ligand. We used the PTHrP and PTH/PTHrP receptor gene knock-out models to investigate whether this receptor mediates the actions of both ligands in bone. The similar phenotype of the PTHrP (−/−) and PTH/PTHrP receptor (−/−) animals in the growth plate of the tibia suggests that this receptor mediates the actions of PTHrP. Electron microscopic studies have confirmed the accelerated differentiation and disordered organization of chondrocytes, with the accumulation of large amounts of dispersed glycogen granules in the cytoplasm of proliferative and maturing cells of both genotypes. The contrasting growth plate mineralization patterns of the PTHrP (−/−) and PTH/PTHrP receptor (−/−) mice, however, suggest that the actions of PTHrP and the PTH/PTHrP receptor are not identical. Studies using calvariae from PTH/PTHrP receptor (−/−) embryos demonstrate that this receptor solely mediates the ability of PTH and PTHrP to stimulate adenylate cyclase in bone and to stimulate bone resorption. Furthermore, we show that osteoblasts of PTH/PTHrP receptor (−/−) animals, but not PTHrP (−/−) animals, have decreased levels of collagenase 3, osteopontin, and osteocalcin messenger RNAs. The PTH/PTHrP receptor, therefore, mediates distinct physiologic actions of both PTH and PTHrP." @default.
• W2073552393 created "2016-06-24" @default.
• W2073552393 creator A5004587580 @default.
• W2073552393 creator A5019506956 @default.
• W2073552393 creator A5021408163 @default.
• W2073552393 creator A5062845949 @default.
• W2073552393 creator A5064629196 @default.
• W2073552393 creator A5066365106 @default.
• W2073552393 creator A5086653323 @default.
• W2073552393 creator A5086976152 @default.
• W2073552393 date "1998-12-01" @default.
• W2073552393 modified "2023-10-10" @default.
• W2073552393 title "The Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Mediates Actions of Both Ligands in Murine Bone**This work was supported by National Institute of Health Grants DK-47038 and AM-03564." @default.
• W2073552393 cites W1502590013 @default.
• W2073552393 cites W1511542029 @default.
• W2073552393 cites W1530894594 @default.
• W2073552393 cites W1532387473 @default.
• W2073552393 cites W1560201422 @default.
• W2073552393 cites W1562645464 @default.
• W2073552393 cites W1568578844 @default.
• W2073552393 cites W1757679215 @default.
• W2073552393 cites W1965963242 @default.
• W2073552393 cites W1966723290 @default.
• W2073552393 cites W1968093456 @default.
• W2073552393 cites W1969080702 @default.
• W2073552393 cites W1970121423 @default.
• W2073552393 cites W1972765252 @default.
• W2073552393 cites W1972983311 @default.
• W2073552393 cites W1977636632 @default.
• W2073552393 cites W1991424506 @default.
• W2073552393 cites W1999241815 @default.
• W2073552393 cites W2000746306 @default.
• W2073552393 cites W2004018263 @default.
• W2073552393 cites W2009435429 @default.
• W2073552393 cites W2018449400 @default.
• W2073552393 cites W2028986797 @default.
• W2073552393 cites W2038500543 @default.
• W2073552393 cites W2040416666 @default.
• W2073552393 cites W2042567846 @default.
• W2073552393 cites W2046102646 @default.
• W2073552393 cites W2046301554 @default.
• W2073552393 cites W2046367200 @default.
• W2073552393 cites W2051300777 @default.
• W2073552393 cites W2051542191 @default.
• W2073552393 cites W2058579856 @default.
• W2073552393 cites W2063301799 @default.
• W2073552393 cites W2067033817 @default.
• W2073552393 cites W2068214398 @default.
• W2073552393 cites W2085530184 @default.
• W2073552393 cites W2090510511 @default.
• W2073552393 cites W2090885889 @default.
• W2073552393 cites W2092759174 @default.
• W2073552393 cites W2092957177 @default.
• W2073552393 cites W2095498651 @default.
• W2073552393 cites W2102179607 @default.
• W2073552393 cites W2109201632 @default.
• W2073552393 cites W2114163924 @default.
• W2073552393 cites W2114528551 @default.
• W2073552393 cites W2142594038 @default.
• W2073552393 cites W2144459502 @default.
• W2073552393 cites W2151887581 @default.
• W2073552393 cites W2163047938 @default.
• W2073552393 cites W2169409481 @default.
• W2073552393 doi "https://doi.org/10.1210/endo.139.12.6361" @default.
• W2073552393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9832460" @default.
• W2073552393 hasPublicationYear "1998" @default.
• W2073552393 type Work @default.
• W2073552393 sameAs 2073552393 @default.
• W2073552393 citedByCount "80" @default.
• W2073552393 countsByYear W20735523932012 @default.
• W2073552393 countsByYear W20735523932013 @default.
• W2073552393 countsByYear W20735523932014 @default.
• W2073552393 countsByYear W20735523932015 @default.
• W2073552393 countsByYear W20735523932016 @default.
• W2073552393 countsByYear W20735523932018 @default.
• W2073552393 countsByYear W20735523932019 @default.
• W2073552393 countsByYear W20735523932020 @default.
• W2073552393 countsByYear W20735523932021 @default.
• W2073552393 crossrefType "journal-article" @default.
• W2073552393 hasAuthorship W2073552393A5004587580 @default.
• W2073552393 hasAuthorship W2073552393A5019506956 @default.
• W2073552393 hasAuthorship W2073552393A5021408163 @default.
• W2073552393 hasAuthorship W2073552393A5062845949 @default.
• W2073552393 hasAuthorship W2073552393A5064629196 @default.
• W2073552393 hasAuthorship W2073552393A5066365106 @default.
• W2073552393 hasAuthorship W2073552393A5086653323 @default.
• W2073552393 hasAuthorship W2073552393A5086976152 @default.
• W2073552393 hasBestOaLocation W20735523931 @default.
• W2073552393 hasConcept C121608353 @default.
• W2073552393 hasConcept C126322002 @default.
• W2073552393 hasConcept C131075544 @default.
• W2073552393 hasConcept C134018914 @default.
• W2073552393 hasConcept C160160445 @default.
• W2073552393 hasConcept C168557967 @default.
• W2073552393 hasConcept C170493617 @default.
• W2073552393 hasConcept C181199279 @default.
• W2073552393 hasConcept C185592680 @default.
• W2073552393 hasConcept C202751555 @default.

• next