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• W2073552707 endingPage "947" @default.
• W2073552707 startingPage "937" @default.
• W2073552707 abstract "In order for axons to reach their proper targets, both spatiotemporal regulation of guidance molecules and stepwise control of growth cone sensitivity to guidance molecules is required. Here, we show that, in zebrafish, Sema3a1, a secreted class 3 semaphorin, plays an essential role in guiding the caudal primary (CaP) motor axon that pioneers the initial region of the motor pathway. The expression pattern of Sema3a1 suggests that it delimits the pioneer CaP axons to the initial, common pathway via a repulsive action, but then CaP axons become insensitive to Sema3a1 beyond the common pathway. Indeed, nrp1a, which probably encodes a component of the Sema3a1 receptor, is specifically expressed by CaP during the early part of its outgrowth but not during later stages when extending into sema3a1-expressing muscle cells. To examine this hypothesis directly,expression of sema3a1 and/or nrp1a was manipulated in several ways. First, antisense knockdown of Sema3a1 induced CaP axons to branch excessively, stall and/or follow aberrant pathways. Furthermore,dynamic analysis showed they extended more lateral filopodia and often failed to pause at the horizontal myoseptal choice point. Second, antisense knockdown of Nrp1a and double knockdown of Nrp1a/Sema3a1 induced similar outgrowth defects in CaP. Third, CaP axons were inhibited by focally misexpressed sema3a1 along the initial common pathway but not along their pathway beyond the common pathway. Thus, as predicted, Sema3a1 is repulsive to CaP axons in the common region of the pathway, but not beyond the common pathway. Fourth, induced ubiquitous overexpression of sema3a1 caused the CaP axons but not the other primary motor axons to follow aberrant pathways. These results suggest that the repulsive response to Sema3a1 of the primary motor axons along the common pathway is both cell-type specific and dynamically regulated, perhaps via regulation of nrp1a." @default.
• W2073552707 created "2016-06-24" @default.
• W2073552707 creator A5016648190 @default.
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• W2073552707 creator A5061823333 @default.
• W2073552707 creator A5070357609 @default.
• W2073552707 creator A5076608250 @default.
• W2073552707 date "2006-03-01" @default.
• W2073552707 modified "2023-09-30" @default.
• W2073552707 title "Sema3a1 guides spinal motor axons in a cell- and stage-specific manner in zebrafish" @default.
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• W2073552707 doi "https://doi.org/10.1242/dev.02268" @default.
• W2073552707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16452100" @default.
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