FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073553590> ?p ?o ?g. }

• W2073553590 endingPage "1538" @default.
• W2073553590 startingPage "1530" @default.
• W2073553590 abstract "Mice with a disrupted gp49B gene, which encodes gp49B1 that is expressed on certain hematopoietic cells and has two immunoreceptor tyrosine-based inhibitory motifs (ITIM), exhibit augmented FcepsilonRI-initiated mast cell degranulation and resultant tissue edema. gp49B1-deficient (gp49B(-/-)) mice also exhibit exaggerated lipopolysaccharide (LPS)-induced intravascular neutrophil aggregation leading to cutaneous microangiopathy. To determine whether gp49B(-/-) mice exhibit elevated cytokine and chemokine levels leading to pathologic inflammation, we quantified clinical and morphologic parameters of arthritis and tissue levels of contributory mediators in gp49B(-/-) and gp49B1-sufficient (gp49B(+/+)) mice injected with anti-type II collagen monoclonal antibody (mAb) and LPS. Clinical scores for joint swelling and histological assessments of synovial thickness and cartilage matrix depletion at day 7 were significantly 2.3- to 2.5-fold greater and were more prolonged in gp49B(-/-) mice. At day 5, the amounts of IL-1beta, macrophage inflammatory protein (MIP)-1alpha, and MIP-2 were 2.1-, 2.5-, and 12-fold greater in joint extracts from gp49B(-/-) mice. A significant 2.7-fold more neutrophils infiltrated the synovium of gp49B(-/-) mice at day 7, and neutrophilia persisted with the delayed resolution of the synovitis. mAb-mediated depletion of neutrophils prevented the synovitis in both strains. Thus, gp49B1 counter-regulates the cytokine and chemokine induction and attendant neutrophilia that are all essential for synovitis and cartilage matrix depletion." @default.
• W2073553590 created "2016-06-24" @default.
• W2073553590 creator A5004621751 @default.
• W2073553590 creator A5021502068 @default.
• W2073553590 creator A5049230198 @default.
• W2073553590 creator A5052600802 @default.
• W2073553590 creator A5058965019 @default.
• W2073553590 creator A5084337863 @default.
• W2073553590 date "2005-05-01" @default.
• W2073553590 modified "2023-10-18" @default.
• W2073553590 title "gp49B1 deficiency is associated with increases in cytokine and chemokine production and severity of proliferative synovitis induced by anti-type II collagen mAb" @default.
• W2073553590 cites W1622558337 @default.
• W2073553590 cites W1638726768 @default.
• W2073553590 cites W1797819854 @default.
• W2073553590 cites W1873874031 @default.
• W2073553590 cites W1902340997 @default.
• W2073553590 cites W1913625561 @default.
• W2073553590 cites W1969075833 @default.
• W2073553590 cites W1970732160 @default.
• W2073553590 cites W1974783945 @default.
• W2073553590 cites W1982709334 @default.
• W2073553590 cites W1987732026 @default.
• W2073553590 cites W1989541056 @default.
• W2073553590 cites W2010042266 @default.
• W2073553590 cites W2026644554 @default.
• W2073553590 cites W2030728818 @default.
• W2073553590 cites W2040562357 @default.
• W2073553590 cites W2065054650 @default.
• W2073553590 cites W2093013241 @default.
• W2073553590 cites W2098724589 @default.
• W2073553590 cites W2105870106 @default.
• W2073553590 cites W2113475878 @default.
• W2073553590 cites W2130892977 @default.
• W2073553590 cites W2136212808 @default.
• W2073553590 cites W2141029341 @default.
• W2073553590 cites W2164066860 @default.
• W2073553590 cites W2168719769 @default.
• W2073553590 cites W25794465 @default.
• W2073553590 cites W2762802665 @default.
• W2073553590 cites W4245099632 @default.
• W2073553590 cites W4249736906 @default.
• W2073553590 doi "https://doi.org/10.1002/eji.200425895" @default.
• W2073553590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15827966" @default.
• W2073553590 hasPublicationYear "2005" @default.
• W2073553590 type Work @default.
• W2073553590 sameAs 2073553590 @default.
• W2073553590 citedByCount "22" @default.
• W2073553590 countsByYear W20735535902012 @default.
• W2073553590 countsByYear W20735535902013 @default.
• W2073553590 countsByYear W20735535902014 @default.
• W2073553590 countsByYear W20735535902016 @default.
• W2073553590 countsByYear W20735535902017 @default.
• W2073553590 countsByYear W20735535902018 @default.
• W2073553590 countsByYear W20735535902021 @default.
• W2073553590 countsByYear W20735535902022 @default.
• W2073553590 countsByYear W20735535902023 @default.
• W2073553590 crossrefType "journal-article" @default.
• W2073553590 hasAuthorship W2073553590A5004621751 @default.
• W2073553590 hasAuthorship W2073553590A5021502068 @default.
• W2073553590 hasAuthorship W2073553590A5049230198 @default.
• W2073553590 hasAuthorship W2073553590A5052600802 @default.
• W2073553590 hasAuthorship W2073553590A5058965019 @default.
• W2073553590 hasAuthorship W2073553590A5084337863 @default.
• W2073553590 hasConcept C13373296 @default.
• W2073553590 hasConcept C17502307 @default.
• W2073553590 hasConcept C203014093 @default.
• W2073553590 hasConcept C2776914184 @default.
• W2073553590 hasConcept C2777077863 @default.
• W2073553590 hasConcept C2777802486 @default.
• W2073553590 hasConcept C2778690821 @default.
• W2073553590 hasConcept C2778754761 @default.
• W2073553590 hasConcept C2779244835 @default.
• W2073553590 hasConcept C5858377 @default.
• W2073553590 hasConcept C86803240 @default.
• W2073553590 hasConceptScore W2073553590C13373296 @default.
• W2073553590 hasConceptScore W2073553590C17502307 @default.
• W2073553590 hasConceptScore W2073553590C203014093 @default.
• W2073553590 hasConceptScore W2073553590C2776914184 @default.
• W2073553590 hasConceptScore W2073553590C2777077863 @default.
• W2073553590 hasConceptScore W2073553590C2777802486 @default.
• W2073553590 hasConceptScore W2073553590C2778690821 @default.
• W2073553590 hasConceptScore W2073553590C2778754761 @default.
• W2073553590 hasConceptScore W2073553590C2779244835 @default.
• W2073553590 hasConceptScore W2073553590C5858377 @default.
• W2073553590 hasConceptScore W2073553590C86803240 @default.
• W2073553590 hasIssue "5" @default.
• W2073553590 hasLocation W20735535901 @default.
• W2073553590 hasLocation W20735535902 @default.
• W2073553590 hasOpenAccess W2073553590 @default.
• W2073553590 hasPrimaryLocation W20735535901 @default.
• W2073553590 hasRelatedWork W112705378 @default.
• W2073553590 hasRelatedWork W1897912748 @default.
• W2073553590 hasRelatedWork W1997736126 @default.
• W2073553590 hasRelatedWork W2073553590 @default.
• W2073553590 hasRelatedWork W2108652407 @default.
• W2073553590 hasRelatedWork W2900979748 @default.
• W2073553590 hasRelatedWork W2901345847 @default.
• W2073553590 hasRelatedWork W3035440422 @default.

• next