FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073560229> ?p ?o ?g. }

• W2073560229 endingPage "4642" @default.
• W2073560229 startingPage "4632" @default.
• W2073560229 abstract "Shogaols, the major constituents of thermally processed ginger, have been proven to be highly effective anticancer agents. Our group has identified cysteine-conjugated shogaols (M2, M2′, and M2″) as the major metabolites of [6]-, [8]-, and [10]-shogaol in human and found that M2 is a carrier of its parent molecule [6]-shogaol in cancer cells and in mice, while being less toxic to normal colon fibroblast cells. The objectives of this study are to determine whether M2′ and M2″ behave in a similar manner to M2, in both metabolism and efficacy as anticancer agents, and to further explore the biological pro-apoptotic mechanisms of the cysteine-conjugated shogaols against human colon cancer cells HCT-116 and HT-29. Our results show that [8]- and [10]-shogaol have similar metabolic profiles to [6]-shogaol and exhibit similar toxicity toward human colon cancer cells. M2′ and M2″ both show low toxicity against normal colon cells but retain potency against colon cancer cells, suggesting that they have similar activity to M2. We further demonstrate that the cysteine-conjugated shogaols can cause cancer cell death through the activation of the mitochondrial apoptotic pathway. Our results show that oxidative stress activates a p53 pathway that ultimately leads to p53 up-regulated modulator of apoptosis (PUMA) induction and down-regulation of B-cell lymphoma 2 (Bcl-2), followed by cytochrome c release, perturbation of inhibitory interactions of X-linked inhibitor of apoptosis protein (XIAP) with caspases, and finally caspase 9 and 3 activation and cleavage. A brief screen of the markers attenuated by the proapoptotic activity of M2 revealed similar results for [8]- and [10]-shogaol and their respective cysteine-conjugated metabolites M2′ and M2″. This study highlights the cysteine-conjugated metabolites of shogaols as novel dietary colon cancer preventive agents." @default.
• W2073560229 created "2016-06-24" @default.
• W2073560229 creator A5002532343 @default.
• W2073560229 creator A5030246693 @default.
• W2073560229 creator A5049058017 @default.
• W2073560229 creator A5053638096 @default.
• W2073560229 creator A5068624754 @default.
• W2073560229 date "2014-05-12" @default.
• W2073560229 modified "2023-10-17" @default.
• W2073560229 title "Cysteine-Conjugated Metabolites of Ginger Components, Shogaols, Induce Apoptosis through Oxidative Stress-Mediated p53 Pathway in Human Colon Cancer Cells" @default.
• W2073560229 cites W134610234 @default.
• W2073560229 cites W1565276921 @default.
• W2073560229 cites W1966271519 @default.
• W2073560229 cites W1970961751 @default.
• W2073560229 cites W1977258127 @default.
• W2073560229 cites W1979650807 @default.
• W2073560229 cites W1981714984 @default.
• W2073560229 cites W1984358846 @default.
• W2073560229 cites W1985914288 @default.
• W2073560229 cites W1998308376 @default.
• W2073560229 cites W2008257691 @default.
• W2073560229 cites W2008357881 @default.
• W2073560229 cites W2008715871 @default.
• W2073560229 cites W2011933419 @default.
• W2073560229 cites W2012299511 @default.
• W2073560229 cites W2012831165 @default.
• W2073560229 cites W2018194882 @default.
• W2073560229 cites W2023623233 @default.
• W2073560229 cites W2023800438 @default.
• W2073560229 cites W2025476423 @default.
• W2073560229 cites W2028344952 @default.
• W2073560229 cites W2034059961 @default.
• W2073560229 cites W2034991912 @default.
• W2073560229 cites W2039919087 @default.
• W2073560229 cites W2042358042 @default.
• W2073560229 cites W2044911368 @default.
• W2073560229 cites W2046302602 @default.
• W2073560229 cites W2048966785 @default.
• W2073560229 cites W2049505262 @default.
• W2073560229 cites W2049637750 @default.
• W2073560229 cites W2054251983 @default.
• W2073560229 cites W2056564326 @default.
• W2073560229 cites W2060513486 @default.
• W2073560229 cites W2061260890 @default.
• W2073560229 cites W2069771069 @default.
• W2073560229 cites W2071443545 @default.
• W2073560229 cites W2073145350 @default.
• W2073560229 cites W2080406700 @default.
• W2073560229 cites W2080915875 @default.
• W2073560229 cites W2082494479 @default.
• W2073560229 cites W2103570093 @default.
• W2073560229 cites W2114417334 @default.
• W2073560229 cites W2114426847 @default.
• W2073560229 cites W2114918609 @default.
• W2073560229 cites W2118587710 @default.
• W2073560229 cites W2125152983 @default.
• W2073560229 cites W2129230108 @default.
• W2073560229 cites W2133959309 @default.
• W2073560229 cites W2153970880 @default.
• W2073560229 cites W2158045076 @default.
• W2073560229 cites W2162396394 @default.
• W2073560229 cites W2166221479 @default.
• W2073560229 cites W2166311908 @default.
• W2073560229 cites W85124676 @default.
• W2073560229 doi "https://doi.org/10.1021/jf501351r" @default.
• W2073560229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4033655" @default.
• W2073560229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24786146" @default.
• W2073560229 hasPublicationYear "2014" @default.
• W2073560229 type Work @default.
• W2073560229 sameAs 2073560229 @default.
• W2073560229 citedByCount "42" @default.
• W2073560229 countsByYear W20735602292014 @default.
• W2073560229 countsByYear W20735602292015 @default.
• W2073560229 countsByYear W20735602292016 @default.
• W2073560229 countsByYear W20735602292017 @default.
• W2073560229 countsByYear W20735602292018 @default.
• W2073560229 countsByYear W20735602292019 @default.
• W2073560229 countsByYear W20735602292020 @default.
• W2073560229 countsByYear W20735602292021 @default.
• W2073560229 countsByYear W20735602292022 @default.
• W2073560229 countsByYear W20735602292023 @default.
• W2073560229 crossrefType "journal-article" @default.
• W2073560229 hasAuthorship W2073560229A5002532343 @default.
• W2073560229 hasAuthorship W2073560229A5030246693 @default.
• W2073560229 hasAuthorship W2073560229A5049058017 @default.
• W2073560229 hasAuthorship W2073560229A5053638096 @default.
• W2073560229 hasAuthorship W2073560229A5068624754 @default.
• W2073560229 hasBestOaLocation W20735602291 @default.
• W2073560229 hasConcept C121608353 @default.
• W2073560229 hasConcept C181199279 @default.
• W2073560229 hasConcept C185592680 @default.
• W2073560229 hasConcept C190283241 @default.
• W2073560229 hasConcept C2776151105 @default.
• W2073560229 hasConcept C2779201268 @default.
• W2073560229 hasConcept C31573885 @default.
• W2073560229 hasConcept C33195913 @default.
• W2073560229 hasConcept C502942594 @default.
• W2073560229 hasConcept C526805850 @default.

• next