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- W2073562413 abstract "Abstract 1. 1. During the period 1934 to 1943, 1,868 new cases of sleeping sickness were aiscovered in the area of Bolobo on the River Congo ; follow-up over a period of 2 years was possible in 1,527 of these. 2. 2. The type of disease encountered is described, and is of medium virulence. 3. 3. The methods of diagnosis, treatment and follow-up are described, and the following conclusions were reached 3.1. (a) That repeated annual surveys resulted in a gradual decrease in the percentage of new cases from 1·55 to 0·48 over this period. 3.2. (b) That repeated annual examination did not allow diagnosis to be made more frequently in the earliest stage of the disease. 3.3. (c) That over a period of 10 years the percentage of cured cases remained approximately the same each year, and there was no rise in the percentage of failures. 4. 4. Tryparsamide alone in moderate dosage gave 80 to 90 per cent. cure in all cases treated, but it is emphasized that this may be only true in this locality and for this type of disease. 5. 5. Cases of “late relapse” are described and may result from a disturbance of the parasite-host balance in those cases in which the infection lies dormant and shows itself by a slightly raised cell count in the C.S.F. over a considerable period. 6. 6. The results of treatment in children are better than in adults, which fact may possibly be explained by the more efficient functioning of the reticulo-endothelial system in young people. Thus the prognosis in any case depends not only on the stage in which the disease is treated but also on the integrity or otherwise of the reticulo-endothelial system." @default.
- W2073562413 created "2016-06-24" @default.
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- W2073562413 date "1950-07-01" @default.
- W2073562413 modified "2023-10-18" @default.
- W2073562413 title "A study of sleeping sickness in an endemic area of the Belgian Congo over a period of ten years" @default.
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- W2073562413 doi "https://doi.org/10.1016/0035-9203(50)90073-3" @default.
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