Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073568903> ?p ?o ?g. }
- W2073568903 endingPage "456" @default.
- W2073568903 startingPage "445" @default.
- W2073568903 abstract "The coordination between cell proliferation and cell death is essential to maintain homeostasis within multicellular organisms. The mechanisms underlying this regulation are yet to be completely understood. Here, we report the identification of hippo (hpo) as a gene that regulates both cell proliferation and cell death in Drosophila. hpo encodes a Ste-20 family protein kinase that binds to and phosphorylates the tumor suppressor protein Salvador (Sav), which is known to interact with the Warts (Wts) protein kinase. Loss of hpo results in elevated transcription of the cell cycle regulator cyclin E and the cell-death inhibitor diap1, leading to increased proliferation and reduced apoptosis. Further, we show that hpo, sav, and wts define a pathway that regulates diap1 at the transcriptional level. A human homolog of hpo completely rescues the overgrowth phenotype of Drosophila hpo mutants, suggesting that hpo might play a conserved role for growth control in mammals." @default.
- W2073568903 created "2016-06-24" @default.
- W2073568903 creator A5027840612 @default.
- W2073568903 creator A5049444908 @default.
- W2073568903 creator A5063499426 @default.
- W2073568903 creator A5087238383 @default.
- W2073568903 date "2003-08-01" @default.
- W2073568903 modified "2023-10-12" @default.
- W2073568903 title "hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts" @default.
- W2073568903 cites W1531523780 @default.
- W2073568903 cites W1912766252 @default.
- W2073568903 cites W1964538721 @default.
- W2073568903 cites W1968883815 @default.
- W2073568903 cites W1974037176 @default.
- W2073568903 cites W1976990850 @default.
- W2073568903 cites W1982124131 @default.
- W2073568903 cites W1997905438 @default.
- W2073568903 cites W2020257412 @default.
- W2073568903 cites W2025693577 @default.
- W2073568903 cites W2028813694 @default.
- W2073568903 cites W2032853143 @default.
- W2073568903 cites W2046930479 @default.
- W2073568903 cites W2049504302 @default.
- W2073568903 cites W2067151543 @default.
- W2073568903 cites W2072692243 @default.
- W2073568903 cites W2074584250 @default.
- W2073568903 cites W2086168468 @default.
- W2073568903 cites W2099072529 @default.
- W2073568903 cites W2103304405 @default.
- W2073568903 cites W2106029142 @default.
- W2073568903 cites W2108143645 @default.
- W2073568903 cites W2116043679 @default.
- W2073568903 cites W2138519364 @default.
- W2073568903 cites W2142276972 @default.
- W2073568903 cites W2159891542 @default.
- W2073568903 cites W2167096785 @default.
- W2073568903 cites W2750896950 @default.
- W2073568903 cites W4255544865 @default.
- W2073568903 doi "https://doi.org/10.1016/s0092-8674(03)00549-x" @default.
- W2073568903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12941273" @default.
- W2073568903 hasPublicationYear "2003" @default.
- W2073568903 type Work @default.
- W2073568903 sameAs 2073568903 @default.
- W2073568903 citedByCount "928" @default.
- W2073568903 countsByYear W20735689032012 @default.
- W2073568903 countsByYear W20735689032013 @default.
- W2073568903 countsByYear W20735689032014 @default.
- W2073568903 countsByYear W20735689032015 @default.
- W2073568903 countsByYear W20735689032016 @default.
- W2073568903 countsByYear W20735689032017 @default.
- W2073568903 countsByYear W20735689032018 @default.
- W2073568903 countsByYear W20735689032019 @default.
- W2073568903 countsByYear W20735689032020 @default.
- W2073568903 countsByYear W20735689032021 @default.
- W2073568903 countsByYear W20735689032022 @default.
- W2073568903 countsByYear W20735689032023 @default.
- W2073568903 crossrefType "journal-article" @default.
- W2073568903 hasAuthorship W2073568903A5027840612 @default.
- W2073568903 hasAuthorship W2073568903A5049444908 @default.
- W2073568903 hasAuthorship W2073568903A5063499426 @default.
- W2073568903 hasAuthorship W2073568903A5087238383 @default.
- W2073568903 hasBestOaLocation W20735689031 @default.
- W2073568903 hasConcept C104317684 @default.
- W2073568903 hasConcept C172512520 @default.
- W2073568903 hasConcept C184235292 @default.
- W2073568903 hasConcept C190283241 @default.
- W2073568903 hasConcept C2777408456 @default.
- W2073568903 hasConcept C29537977 @default.
- W2073568903 hasConcept C31573885 @default.
- W2073568903 hasConcept C54355233 @default.
- W2073568903 hasConcept C62112901 @default.
- W2073568903 hasConcept C6929976 @default.
- W2073568903 hasConcept C86339819 @default.
- W2073568903 hasConcept C86803240 @default.
- W2073568903 hasConcept C95444343 @default.
- W2073568903 hasConceptScore W2073568903C104317684 @default.
- W2073568903 hasConceptScore W2073568903C172512520 @default.
- W2073568903 hasConceptScore W2073568903C184235292 @default.
- W2073568903 hasConceptScore W2073568903C190283241 @default.
- W2073568903 hasConceptScore W2073568903C2777408456 @default.
- W2073568903 hasConceptScore W2073568903C29537977 @default.
- W2073568903 hasConceptScore W2073568903C31573885 @default.
- W2073568903 hasConceptScore W2073568903C54355233 @default.
- W2073568903 hasConceptScore W2073568903C62112901 @default.
- W2073568903 hasConceptScore W2073568903C6929976 @default.
- W2073568903 hasConceptScore W2073568903C86339819 @default.
- W2073568903 hasConceptScore W2073568903C86803240 @default.
- W2073568903 hasConceptScore W2073568903C95444343 @default.
- W2073568903 hasIssue "4" @default.
- W2073568903 hasLocation W20735689031 @default.
- W2073568903 hasLocation W20735689032 @default.
- W2073568903 hasOpenAccess W2073568903 @default.
- W2073568903 hasPrimaryLocation W20735689031 @default.
- W2073568903 hasRelatedWork W1967264415 @default.
- W2073568903 hasRelatedWork W1987695408 @default.
- W2073568903 hasRelatedWork W2003720298 @default.
- W2073568903 hasRelatedWork W2031840568 @default.
- W2073568903 hasRelatedWork W2141091145 @default.