Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073570537> ?p ?o ?g. }
- W2073570537 endingPage "370" @default.
- W2073570537 startingPage "135" @default.
- W2073570537 abstract "Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a high social cost. Depressed patients generally display co-morbid symptoms, and depression frequently accompanies other serious disorders. Currently available drugs display limited efficacy and a pronounced delay to onset of action, and all provoke distressing side effects. Cloning of the human genome has fuelled expectations that symptomatic treatment may soon become more rapid and effective, and that depressive states may ultimately be “prevented” or “cured”. In pursuing these objectives, in particular for genome-derived, non-monoaminergic targets, “specificity” of drug actions is often emphasized. That is, priority is afforded to agents that interact exclusively with a single site hypothesized as critically involved in the pathogenesis and/or control of depression. Certain highly selective drugs may prove effective, and they remain indispensable in the experimental (and clinical) evaluation of the significance of novel mechanisms. However, by analogy to other multifactorial disorders, “multi-target” agents may be better adapted to the improved treatment of depressive states. Support for this contention is garnered from a broad palette of observations, ranging from mechanisms of action of adjunctive drug combinations and electroconvulsive therapy to “network theory” analysis of the etiology and management of depressive states. The review also outlines opportunities to be exploited, and challenges to be addressed, in the discovery and characterization of drugs recognizing multiple targets. Finally, a diversity of multi-target strategies is proposed for the more efficacious and rapid control of core and co-morbid symptoms of depression, together with improved tolerance relative to currently available agents." @default.
- W2073570537 created "2016-06-24" @default.
- W2073570537 creator A5041494494 @default.
- W2073570537 date "2006-05-01" @default.
- W2073570537 modified "2023-10-18" @default.
- W2073570537 title "Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application" @default.
- W2073570537 cites W106994774 @default.
- W2073570537 cites W107021117 @default.
- W2073570537 cites W107475310 @default.
- W2073570537 cites W109954717 @default.
- W2073570537 cites W114718013 @default.
- W2073570537 cites W116369744 @default.
- W2073570537 cites W118142303 @default.
- W2073570537 cites W121409461 @default.
- W2073570537 cites W124461014 @default.
- W2073570537 cites W1265796269 @default.
- W2073570537 cites W127595161 @default.
- W2073570537 cites W133146910 @default.
- W2073570537 cites W137814523 @default.
- W2073570537 cites W1479796757 @default.
- W2073570537 cites W1481508412 @default.
- W2073570537 cites W1482204318 @default.
- W2073570537 cites W1483073498 @default.
- W2073570537 cites W1484089182 @default.
- W2073570537 cites W148515705 @default.
- W2073570537 cites W1486607502 @default.
- W2073570537 cites W1487233798 @default.
- W2073570537 cites W1488313827 @default.
- W2073570537 cites W1489250519 @default.
- W2073570537 cites W1491097823 @default.
- W2073570537 cites W1493305388 @default.
- W2073570537 cites W1493374490 @default.
- W2073570537 cites W1493678624 @default.
- W2073570537 cites W1498765145 @default.
- W2073570537 cites W1499954868 @default.
- W2073570537 cites W1501004659 @default.
- W2073570537 cites W1502362666 @default.
- W2073570537 cites W1503315385 @default.
- W2073570537 cites W1505495051 @default.
- W2073570537 cites W1507338157 @default.
- W2073570537 cites W1509452133 @default.
- W2073570537 cites W1516150813 @default.
- W2073570537 cites W1519701208 @default.
- W2073570537 cites W1521948202 @default.
- W2073570537 cites W1522302812 @default.
- W2073570537 cites W1524125780 @default.
- W2073570537 cites W1524239110 @default.
- W2073570537 cites W1525221498 @default.
- W2073570537 cites W1525530024 @default.
- W2073570537 cites W1525605527 @default.
- W2073570537 cites W1525839404 @default.
- W2073570537 cites W1526674447 @default.
- W2073570537 cites W1528597597 @default.
- W2073570537 cites W1536743176 @default.
- W2073570537 cites W1538619854 @default.
- W2073570537 cites W1539046970 @default.
- W2073570537 cites W1539568317 @default.
- W2073570537 cites W1543923901 @default.
- W2073570537 cites W1544821866 @default.
- W2073570537 cites W1545337623 @default.
- W2073570537 cites W1546098811 @default.
- W2073570537 cites W1546116904 @default.
- W2073570537 cites W1547130418 @default.
- W2073570537 cites W1550289802 @default.
- W2073570537 cites W1551782890 @default.
- W2073570537 cites W1551922701 @default.
- W2073570537 cites W1554938697 @default.
- W2073570537 cites W1555054303 @default.
- W2073570537 cites W1555810878 @default.
- W2073570537 cites W1557660450 @default.
- W2073570537 cites W1558862799 @default.
- W2073570537 cites W1559767375 @default.
- W2073570537 cites W1561126551 @default.
- W2073570537 cites W1561569944 @default.
- W2073570537 cites W1561607325 @default.
- W2073570537 cites W1561762214 @default.
- W2073570537 cites W1563560198 @default.
- W2073570537 cites W1565746371 @default.
- W2073570537 cites W1569823139 @default.
- W2073570537 cites W1570313229 @default.
- W2073570537 cites W1571074538 @default.
- W2073570537 cites W1572525448 @default.
- W2073570537 cites W1572640345 @default.
- W2073570537 cites W1574542597 @default.
- W2073570537 cites W1578458397 @default.
- W2073570537 cites W1578713285 @default.
- W2073570537 cites W1582319996 @default.
- W2073570537 cites W1589264845 @default.
- W2073570537 cites W1589821828 @default.
- W2073570537 cites W1589992431 @default.
- W2073570537 cites W1592483428 @default.
- W2073570537 cites W1594539812 @default.
- W2073570537 cites W1595449036 @default.
- W2073570537 cites W1597915293 @default.
- W2073570537 cites W1598363147 @default.
- W2073570537 cites W1598392065 @default.
- W2073570537 cites W1598896797 @default.
- W2073570537 cites W1599207601 @default.