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• W2073572214 abstract "Summary o 1. The multiple simultaneous dilution technique has been employed to measure alterations in body composition occurring in dogs with surgically produced cardiac valvular lesions. Control studies in the normal state were followed by repeated estimations in the same animals with mild valvular damage (tricuspid insufficiency), and subsequently in the state of florid congestive heart failure (tricuspid insufficiency plus pulmonary stenosis). 2. The pattern of change has in general corresponded to that emerging from previous studies in the human. Total body water (TBW), exchangeable sodium (Nae) and exchangeable chloride (Cle) were found to be significantly elevated even in the earliest stage of valvular damage (TI), and grossly elevated in the stage of congestive failure (TI and PS). Exchangeable potassium (Ke) and red cell volume (RV) on the other hand were elevated in the stage of mild valvular damage but subsequently returned to control values in the stage of gross heart failure. 3. In a few details the response of the dog appears to differ from that in man. Hyponatremia is not a regular result of congestive heart failure; the expansion of body water is even greater than is seen in man and the ratio Nae+Ke/TBW is maintained at a higher level in the dog than in man in congestive heart failure. 4. The significance of these variations is discussed in the light of current knowledge." @default.
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• W2073572214 date "1962-07-01" @default.
• W2073572214 modified "2023-09-24" @default.
• W2073572214 title "Body composition in the dog. II. The effect of progressive congestive heart failure" @default.
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• W2073572214 doi "https://doi.org/10.1016/s0022-4804(62)80018-3" @default.
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