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- W2073587921 abstract "Myeloma bone disease was first described in 1848 in a London tradesman called Thomas Alexander McBean[ 1 MacIntyre W. Case of mollities and fragilitas ossium accompanied with urine strongly charged with animal matter. Med Chir Soc Tr. 1850; 33: 211 PubMed Google Scholar ]. The patient was a 42 year old man who suffered a severe and debilitating form of bone disease which was called by physicians mollities and fragilitas ossium (disease with soft bones). He was found to have a newly identified substance in his urine which had special chemical properties and which subsequently came to be known as Bence Jones protein[ 2 Bence Jones H. Papers on chemical pathology: prefaced by the Gulstonian lectures, read at the Royal College of Physicians. Proc Royal Society London. Lancet. 1847; ii: 88 Abstract Scopus (34) Google Scholar ]. It is now recognised to be a consequence of the presence of monoclonal free light chains of immunoglobulin molecules produced by myeloma cells." @default.
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- W2073587921 date "1998-02-01" @default.
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- W2073587921 title "Myeloma bone disease" @default.
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- W2073587921 doi "https://doi.org/10.1016/s0959-8049(97)10133-2" @default.
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