FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073592717> ?p ?o ?g. }

• W2073592717 endingPage "7390" @default.
• W2073592717 startingPage "7385" @default.
• W2073592717 abstract "Pore-forming toxins (PFTs) are potent cytolytic agents secreted by pathogenic bacteria that protect microbes against the cell-mediated immune system (by targeting phagocytic cells), disrupt epithelial barriers, and liberate materials necessary to sustain growth and colonization. Produced by gram-positive and gram-negative bacteria alike, PFTs are released as water-soluble monomeric or dimeric species, bind specifically to target membranes, and assemble transmembrane channels leading to cell damage and/or lysis. Structural and biophysical analyses of individual steps in the assembly pathway are essential to fully understanding the dynamic process of channel formation. To work toward this goal, we solved by X-ray diffraction the 2.9-Å structure of the 450-kDa heptameric Vibrio cholerae cytolysin (VCC) toxin purified and crystallized in the presence of detergent. This structure, together with our previously determined 2.3-Å structure of the VCC water-soluble monomer, reveals in detail the architectural changes that occur within the channel region and accessory lectin domains during pore formation including substantial rearrangements of hydrogen-bonding networks in the pore-forming amphipathic loops. Interestingly, a ring of tryptophan residues forms the narrowest constriction in the transmembrane channel reminiscent of the phenylalanine clamp identified in anthrax protective antigen [Krantz BA, et al. (2005) Science 309:777-781]. Our work provides an example of a β-barrel PFT (β-PFT) for which soluble and assembled structures are available at high-resolution, providing a template for investigating intermediate steps in assembly." @default.
• W2073592717 created "2016-06-24" @default.
• W2073592717 creator A5009682871 @default.
• W2073592717 creator A5035886269 @default.
• W2073592717 date "2011-04-18" @default.
• W2073592717 modified "2023-10-01" @default.
• W2073592717 title "Crystal structure of the <i>Vibrio cholerae</i> cytolysin heptamer reveals common features among disparate pore-forming toxins" @default.
• W2073592717 cites W1506811553 @default.
• W2073592717 cites W1539796472 @default.
• W2073592717 cites W1539834786 @default.
• W2073592717 cites W1558207034 @default.
• W2073592717 cites W1820852202 @default.
• W2073592717 cites W1963304091 @default.
• W2073592717 cites W1964201309 @default.
• W2073592717 cites W1968889490 @default.
• W2073592717 cites W1974845262 @default.
• W2073592717 cites W1975661657 @default.
• W2073592717 cites W1975915958 @default.
• W2073592717 cites W1982830687 @default.
• W2073592717 cites W1983928264 @default.
• W2073592717 cites W1986503058 @default.
• W2073592717 cites W1990173904 @default.
• W2073592717 cites W1992552225 @default.
• W2073592717 cites W1995017064 @default.
• W2073592717 cites W1996294482 @default.
• W2073592717 cites W1997769724 @default.
• W2073592717 cites W2001641653 @default.
• W2073592717 cites W2007395394 @default.
• W2073592717 cites W2009830520 @default.
• W2073592717 cites W2021319373 @default.
• W2073592717 cites W2029582401 @default.
• W2073592717 cites W2030683115 @default.
• W2073592717 cites W2035899761 @default.
• W2073592717 cites W2036430109 @default.
• W2073592717 cites W2038046723 @default.
• W2073592717 cites W2038317410 @default.
• W2073592717 cites W2038840577 @default.
• W2073592717 cites W2046154093 @default.
• W2073592717 cites W2065152402 @default.
• W2073592717 cites W2068572525 @default.
• W2073592717 cites W2073038487 @default.
• W2073592717 cites W2073144764 @default.
• W2073592717 cites W2078418955 @default.
• W2073592717 cites W2090821297 @default.
• W2073592717 cites W2092379209 @default.
• W2073592717 cites W2101532349 @default.
• W2073592717 cites W2105430590 @default.
• W2073592717 cites W2109184569 @default.
• W2073592717 cites W2121615663 @default.
• W2073592717 cites W2122339645 @default.
• W2073592717 cites W2122541606 @default.
• W2073592717 cites W2126496238 @default.
• W2073592717 cites W2131350133 @default.
• W2073592717 cites W2132301781 @default.
• W2073592717 cites W2132629607 @default.
• W2073592717 cites W2135426057 @default.
• W2073592717 cites W2136558879 @default.
• W2073592717 cites W2144081223 @default.
• W2073592717 cites W2149268836 @default.
• W2073592717 cites W2149863352 @default.
• W2073592717 cites W2153738223 @default.
• W2073592717 cites W2164801267 @default.
• W2073592717 cites W2168731792 @default.
• W2073592717 doi "https://doi.org/10.1073/pnas.1017442108" @default.
• W2073592717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3088620" @default.
• W2073592717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21502531" @default.
• W2073592717 hasPublicationYear "2011" @default.
• W2073592717 type Work @default.
• W2073592717 sameAs 2073592717 @default.
• W2073592717 citedByCount "112" @default.
• W2073592717 countsByYear W20735927172012 @default.
• W2073592717 countsByYear W20735927172013 @default.
• W2073592717 countsByYear W20735927172014 @default.
• W2073592717 countsByYear W20735927172015 @default.
• W2073592717 countsByYear W20735927172016 @default.
• W2073592717 countsByYear W20735927172017 @default.
• W2073592717 countsByYear W20735927172018 @default.
• W2073592717 countsByYear W20735927172019 @default.
• W2073592717 countsByYear W20735927172020 @default.
• W2073592717 countsByYear W20735927172021 @default.
• W2073592717 countsByYear W20735927172022 @default.
• W2073592717 countsByYear W20735927172023 @default.
• W2073592717 crossrefType "journal-article" @default.
• W2073592717 hasAuthorship W2073592717A5009682871 @default.
• W2073592717 hasAuthorship W2073592717A5035886269 @default.
• W2073592717 hasBestOaLocation W20735927171 @default.
• W2073592717 hasConcept C104317684 @default.
• W2073592717 hasConcept C115260700 @default.
• W2073592717 hasConcept C121332964 @default.
• W2073592717 hasConcept C125235067 @default.
• W2073592717 hasConcept C12554922 @default.
• W2073592717 hasConcept C142089489 @default.
• W2073592717 hasConcept C170493617 @default.
• W2073592717 hasConcept C174921431 @default.
• W2073592717 hasConcept C178790620 @default.
• W2073592717 hasConcept C185592680 @default.
• W2073592717 hasConcept C24530287 @default.
• W2073592717 hasConcept C2776403692 @default.

• next